Search Results

Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.

Multiple myeloma (MM) is characterized by osteolytic bone lesions with uncoupled bone remodeling. In this study, we examined the effects of adenosine and its receptors (A1R, A2AR, A2BR, and A3R) on osteoblast and osteoclast differentiation of cells...

Authors: He W, Mazumder A, Wilder T, Cronstein BN

SST Peer Reviewed

miR-411 is up-regulated in FSHD myoblasts and suppresses myogenic factors.

BACKGROUND: Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscle disorder, which is linked to the contraction of the D4Z4 array at chromosome 4q35. Recent studies suggest that this shortening of the D4Z4 array leads to...

Authors: Harafuji N1, Schneiderat P, Walter MC, Chen YW.

Regulation of cell shape and adhesion by CD34.

We previously reported that expression of CD43/leukosialin induces cell rounding and microvillus formation via inhibition of cell adhesion. Here, we found that CD34, a cell surface sialomucin and marker for hematopoietic progenitor cells, also...

Authors: Ohnishi H, Sasaki H, Nakamura Y, Kato S, Ando K, Narimatsu H, Tachibana K

SST Peer Reviewed

Diploid chromosome number and chromosomal variation in the white rhinoceros (Ceratotherium simum).

Chromosomal studies were conducted on 38 white rhinoceroses representing both the northern and southern subspecies and one subspecies hybrid. Improvements in tissue culture methods and harvesting techniques have made it possible to obtain a highly...

Authors: Houck ML, Ryder OA, Váhala J, Kock RA, Oosterhuis JE

Unique responses of stem cell-derived vascular endothelial and mesenchymal cells to high levels of glucose

Diabetes leads to complications in selected organ systems, and vascular endothelial cell (EC) dysfunction and loss is the key initiating and perpetuating step in the development of these complications. Experimental and clinical studies have shown...

Authors: Keats E, Khan ZA

SST Peer Reviewed

Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes

Umbilical cord blood (CB) is a valuable source of stem cells for transplantation, but CB transplantations are frequently complicated by delayed platelet engraftment. The reasons underlying this are unclear. We hypothesized that CB- and...

Authors: Pastos KM, Slayton WB, Rimsza LM, Young L, Sola-Visner MC

SST Peer Reviewed

MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis.

Dysregulation of epigenetic controls is associated with tumorigenesis in response to microenvironmental stimuli; however, the regulatory pathways involved in epigenetic dysfunction are largely unclear. We have determined that a critical epigenetic...

Authors: Chao CH, Chang CC, Wu MJ, Ko HW, Wang D, Hung MC, Yang JY, Chang CJ

Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders.

Human induced pluripotent stem (iPS) cells derived from somatic cells hold promise to develop novel patient-specific cell therapies and research models for inherited and acquired diseases. We and others previously reprogrammed human adherent cells,...

Authors: Ye Z, Zhan H, Mali P, Dowey S, Williams DM, Jang YY, Dang CV, Spivak JL, Moliterno AR, Cheng L

SST Peer Reviewed

Assessment of an Efficient Xeno-Free Culture System of Human Periodontal Ligament Stem Cells

The possibility of transplanting adult stem cells into damaged organs has opened new prospects for the treatment of several human pathologies. The purpose of this study was to develop a culture system for the expansion and production of human...

Authors: Trubiani O, Piattelli A, Gatta V, Marchisio M, Diomede F, D\\\'Aurora M, Merciaro I, Pierdomenico L,...

SST Peer Reviewed

HDAC11 is a novel drug target in carcinomas

Inhibition of histone deacetylase (HDAC) activity as stand-alone or combination therapy represents a promising therapeutic approach in oncology. The pan- or class I HDAC inhibitors (HDACi) currently approved or in clinical studies for oncology give...

Authors: Deubzer HE1, Schier MC, Oehme I, Lodrini M, Haendler B, Sommer A, Witt O.

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Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.

miR-411 is up-regulated in FSHD myoblasts and suppresses myogenic factors.

Regulation of cell shape and adhesion by CD34.

Diploid chromosome number and chromosomal variation in the white rhinoceros (Ceratotherium simum).

Unique responses of stem cell-derived vascular endothelial and mesenchymal cells to high levels of glucose

Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes

MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis.

Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders.

Assessment of an Efficient Xeno-Free Culture System of Human Periodontal Ligament Stem Cells

HDAC11 is a novel drug target in carcinomas