Search Results

Optimization and validation of CAR transduction into human primary NK cells using CRISPR and AAV

Human primary natural killer (NK) cells are being widely advanced for cancer immunotherapy. However, methods for gene editing of these cells have suffered low transduction rates, high cell death, and loss of transgene expression after expansion....

Authors: Naeimi Kararoudi M, Likhite S, Elmas E, Yamamoto K, Schwartz M, Sorathia K, de Souza Fernandes...

SST Peer Reviewed

Altered COVID-19 Receptor ACE2 Expression in a Higher Risk Group for Cerebrovascular Disease and Ischemic Stroke

Coronavirus disease 2019 (COVID-19) is a worldwide pandemic. It has a high transmission rate among humans, and is a threat to global public health. However, there are no effective prophylactics or therapeutics available. It is necessary to identify...

Authors: Choi JY, Lee HK, Park JH, Cho SJ, Kwon M, Jo C, Koh YH

SST Peer Reviewed

Helios enhances the preferential differentiation of human fetal CD4+ naïve T cells into regulatory T cells

T cell receptor (TCR) stimulation and cytokine cues drive the differentiation of CD4+ naïve T cells into effector T cell populations with distinct proinflammatory or regulatory functions. Unlike adult naïve T cells, human fetal naïve CD4+ T...

Authors: Ng MSF, Roth TL, Mendoza VF, Marson A, Burt TD

Hypoxia induces expression of angiotensin-converting enzyme II in alveolar epithelial cells: Implications for the pathogenesis of acute lung injury in COVID-19

SARS-CoV-2 uptake by lung epithelial cells is a critical step in the pathogenesis of COVID-19. Viral entry is dependent on the binding of the viral spike protein to the angiotensin converting enzyme II protein (ACE2) on the host cell surface,...

Authors: Anne Sturrock, Elizabeth Zimmerman, My Helms, Theodore G Liou, Robert Paine 3rd

SST Peer Reviewed

A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers

B cell-activating factor (BAFF) binds the three receptors BAFF-R, BCMA, and TACI, predominantly expressed on mature B cells. Almost all B cell cancers are reported to express at least one of these receptors. Here we develop a BAFF ligand-based...

Authors: Derek P Wong , Nand K Roy , Keman Zhang , Anusha Anukanth, Abhishek Asthana , Nicole J...

CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells

The combination of genome-edited human embryonic stem cells (hESCs) and subsequent neural differentiation is a powerful tool to study neurodevelopmental disorders. Since the naïve state of pluripotency has favourable characteristics for efficient...

Authors: Eva Z Jacobs, Sharat Warrier, Pieter-Jan Volders, Eva D'haene, Eva Van Lombergen, Lies...

SST Peer Reviewed

Identification of a Potential Biomarker for FABP4Inhibition: The Power of Lipidomics in Preclinical Drug Testing

The fatty acid binding protein 4 (FABP4) belongs to the family of lipid chaperones that control intracellular fluxes and compartmentalizationof their respective ligands (e.g., fatty acids). FABP4, which is almost exclusively expressed in...

Authors: Karsten Suhre, Werner Römisch-Margl, Martin Hrabé de Angelis,Jerzy Adamski, Gerd Luippold, and...

Generation of Tetrafluoroethylene-Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies

Polydimethylsiloxane (PDMS) is widely used to fabricate microfluidic organs-on-chips. Using these devices (PDMS-based devices), the mechanical microenvironment of living tissues, such as pulmonary respiration and intestinal peristalsis, can be...

Authors: Emi Sano, Sayaka Deguchi , Naoki Matsuoka , Masahiro Tsuda, Mengyang Wang , Kaori Kosugi Chihiro...

IL-7 receptor influences anti-TNFresponsiveness and T cell gut homing ininflammatory bowel disease

It remains unknown what causes inflammatory bowel disease (IBD), including signaling networks perpetuating chronicgastrointestinal inflammation in Crohn’s disease (CD) and ulcerative colitis (UC), in humans. According to an analysis of up to500...

Authors: Lyssia Belarif, Bernard Vanhove, Nicolas Poirier

Genome editing of donor-derived T-cells to generate allogenic chimeric antigen receptor-modified T cells: Optimizing aß T cell-depleted haploidentical hematopoietic stem cell transplantation

Allogeneic hematopoietic stem cell transplantation is an effective therapy for high-risk leukemias. In children, graft manipulation based on the selective removal of aß T cells and B cells has been shown to reduce the risk of acute and chronic...

Authors: Volker Wiebking , Ciaran M Lee , Nathalie Mostrel , Premanjali Lahiri , Rasmus Bak , Gang Bao ,...

SST Peer Reviewed

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Optimization and validation of CAR transduction into human primary NK cells using CRISPR and AAV

Altered COVID-19 Receptor ACE2 Expression in a Higher Risk Group for Cerebrovascular Disease and Ischemic Stroke

Helios enhances the preferential differentiation of human fetal CD4+ naïve T cells into regulatory T cells

Hypoxia induces expression of angiotensin-converting enzyme II in alveolar epithelial cells: Implications for the pathogenesis of acute lung injury in COVID-19

A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers

CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells

Identification of a Potential Biomarker for FABP4Inhibition: The Power of Lipidomics in Preclinical Drug Testing

Generation of Tetrafluoroethylene-Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies

IL-7 receptor influences anti-TNFresponsiveness and T cell gut homing ininflammatory bowel disease

Genome editing of donor-derived T-cells to generate allogenic chimeric antigen receptor-modified T cells: Optimizing aß T cell-depleted haploidentical hematopoietic stem cell transplantation