Search Results

3,3\\\'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells.

We recently reported that novel ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells. In this paper, we have focused on the mechanism(s) associated...

Authors: Goldberg AA1, Draz H2, Montes-Grajales D3, Olivero-Verbél J3, Safe SH4, Sanderson JT5

Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human Genome.

Clustered DNA damage is defined as multiple sites of DNA damage within one or two helical turns of the duplex DNA. This complex damage is often formed by exposure of the genome to ionizing radiation and is difficult to repair. The mutagenic potential...

Authors: Sassa A, Kamoshita N, Kanemaru Y, Honma M, Yasui M.

SST Peer Reviewed

The role of Src family kinases in growth and migration of glioma stem cells.

Src family kinases (SFKs) are highly expressed and active in clinical glioblastoma multiforme (GBM) specimens. SFKs inhibitors have been demonstrated to inhibit proliferation and migration of glioma cells. However, the role of SFKs in glioma stem...

Authors: Han X1, Zhang W1, Yang X1, Wheeler CG1, Langford CP2, Wu L1, Filippova N1, Friedman GK3, Ding Q4,...

BAC-based cellular model for screening regulators of BDNF gene transcription.

BACKGROUND: Brain derived neurotrophic factor (BDNF) belongs to a family of structurally related proteins called neurotrophins that have been shown to regulate survival and growth of neurons in the developing central and peripheral nervous system...

Authors: Jaanson K1, Sepp M, Aid-Pavlidis T, Timmusk T.

A vaccine strategy with multiple prostatic acid phosphatase-fused cytokines for prostate cancer treatment

Immunotherapy is one of the attractive treatment strategies for advanced prostate cancer. The US Food and Drug Administration (FDA) previously approved the therapeutic vaccine, sipuleucel-T, which is composed of autologous antigen-presenting cells...

Authors: Fujio K, Watanabe M, Ueki H, Li SA1, Kinoshita R, Ochiai K, Futami J, Watanabe T, Nasu Y, Kumon H.

A Role for Rab7 in the Movement of Secretory Granules in Cytotoxic T Lymphocytes

Cytotoxic T lymphocytes (CTL) are potent killers of virally infected and tumorigenic cells. Upon recognition of target cells, CTL undergo polarized secretion of secretory lysosomes at the immunological synapse (IS) that forms between CTL and target....

Authors: Daniele T, Hackmann Y, Ritter AT, Wenham M, Booth S, Bossi G, Schintler M, Auer-Grumbach M,...

Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma

PURPOSE: The role of phosphatidylcholine-specific phospholipase C (PC-PLC), the enzyme involved in cell differentiation and proliferation, has not yet been explored in tumor initiating cells (TICs). We investigated PC-PLC expression and effects of...

Authors: Cecchetti S, Bortolomai I, Ferri R, Mercurio L, Canevari S, Podo F, Miotti S, Iorio E.

Induction of reactive oxygen species by human T-cell leukemia virus type 1 tax correlates with DNA damage and expression of cellular senescence marker

Human T-cell leukemia virus type 1 (HTLV-1) Tax affects cellular genomic stability and senescence. As yet, the mechanism(s) for these events caused by Tax is incompletely understood. Here, we show that Tax expression in primary human cells induces...

Authors: Kinjo T, Ham-Terhune J, Peloponese JM Jr, Jeang KT

Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells.

Targeted nucleases, including zinc-finger nucleases (ZFNs), transcription activator-like (TAL) effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9), have provided...

Authors: Jia Liu, Thomas Gaj, Yifeng Yang, Nan Wang, Sailan Shui, Sojung Kim, Chidananda Nagamangala...

SST Peer Reviewed

Stemness of the hybrid Epithelial/ Mesenchymal State in Breast Cancer and Its Association with Poor Survival

Breast cancer stem cells (CSCs) are thought to drive recurrence and metastasis. Their identity has been linked to the epithelial to mesenchymal transition (EMT) but remains highly controversial since--depending on the cell-line studied--either...

Authors: Grosse-Wilde A, Fouquier d\\\'Hérouël A, McIntosh E, Ertaylan G, Skupin A, Kuestner RE, del Sol A,...

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