Search Results

RIG-I contributes to the innate immune response after cerebral ischemia

BACKGROUND: Focal cerebral ischemia induces an inflammatory response that when exacerbated contributes to deleterious outcomes. The molecular basis regarding the regulation of the innate immune response after focal cerebral ischemia remains poorly...

Authors: Brand FJ 3rd, de Rivero Vaccari JC, Mejias NH, Alonso OF, de Rivero Vaccari JP.

A platform for rapid prototyping of synthetic gene networks in mammalian cells

Mammalian synthetic biology may provide novel therapeutic strategies, help decipher new paths for drug discovery and facilitate synthesis of valuable molecules. Yet, our capacity to genetically program cells is currently hampered by the lack of...

Authors: Duportet X, Wroblewska L, Guye P, Li Y, Eyquem J, Rieders J, Rimchala T, Batt G, Weiss R.

SST Peer Reviewed

CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants

The vast majority of disease-associated single-nucleotide polymorphisms (SNPs) mapped by genome-wide association studies (GWASs) are located in the non-protein-coding genome, but establishing the functional and mechanistic roles of these sequence...

Authors: Sándor Spisák, Kate Lawrenson, Yanfang Fu, István Csabai, Rebecca T Cottman, Ji-Heui Seo,...

SST Peer Reviewed

Effects of Parathyroid Hormone-Related Peptide on the Large Conductance Calcium-Activated Potassium Channel and Calcium Homeostasis in Vascular Smooth Muscle Cells

AIM: To demonstrate the impact of the parathyroid hormone-related peptide (PTHrP) on the large conductance calcium-activated potassium (BKCa) channels in vascular smooth muscle cells (VSMC) and hyperpolarization of the cell membrane and its...

Authors: Kamil Mehmet Burgazli, Nikolaus Foerster, Meric Mericliler, Ritvan Chasan, Mariana Parahuleva, Ali...

In vitro cardiomyocyte differentiation of umbilical cord blood cells: crucial role for c-kit(+) cells.

BACKGROUND AIMS: Although bone marrow c-kit(+) progenitor cells support myocardial regeneration, the cardiomyocyte differentiation potential of umbilical cord blood (UCB) c-kit(+) cells is unknown. METHODS: UCB mononuclear cells (MNCs) and...

Authors: Iachininoto MG, Capodimonti S, Podda MV, Valentini CG, Bianchi M, Leone AM, Teofili L, Leone G

Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification

Transcription factors (TFs) act within wider regulatory networks to control cell identity and fate. Numerous TFs, including Scl (Tal1) and PU.1 (Spi1), are known regulators of developmental and adult haematopoiesis, but how they act within wider TF...

Authors: Adam C. Wilkinson, Viviane K. S. Kawata, Judith Schütte, Xuefei Gao, Stella Antoniou, Claudia...

The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons.

The molecular composition of the cannabinoid type 1 (CB1) receptor complex beyond the classical G-protein signaling components is not known. Using proteomics on mouse cortex in vivo, we pulled down proteins interacting with CB1 in neurons and show...

Authors: Christian Njoo, Nitin Agarwal, Beat Lutz, Rohini Kuner

Regulatory effects of fibroblast growth factor-8 and tumor necrosis factor-a on osteoblast marker expression induced by bone morphogenetic protein-2.

BMP induces osteoblast differentiation, whereas a key proinflammatory cytokine, TNF-a, causes inflammatory bone damage shown in rheumatoid arthritis. FGF molecules are known to be involved in bone homeostasis. However, the effects of FGF-8 on...

Authors: Katsuyama T, Otsuka F, Terasaka T, Inagaki K, Takano-Narazaki M, Matsumoto Y, Sada KE, Makino H.

Targeting CD20+ Aggressive B-cell Non-Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells In Vitro and in NSG Mice.

The prognosis is very dismal for patients with relapsed CD20(+) B-cell non-Hodgkin lymphoma (B-NHL). Facilitating the development of alternative novel therapeutic strategies is required to improve outcomes in patients with recurrent/refractory...

Authors: Chu Y, Hochberg J, Yahr A, Ayello J, van de Ven C, Barth M, Czuczman M, Cairo MS.

SST Peer Reviewed

Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs

Molecular beacons (MBs) are dual-labeled oligonucleotides that fluoresce only in the presence of complementary mRNA. The use of MBs to target specific mRNAs allows sorting of specific cells from a mixed cell population. In contrast to existing...

Authors: Brian M Wile, Kiwon Ban, Young-Sup Yoon, Gang Bao

SST Peer Reviewed

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin

RIG-I contributes to the innate immune response after cerebral ischemia

A platform for rapid prototyping of synthetic gene networks in mammalian cells

CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants

Effects of Parathyroid Hormone-Related Peptide on the Large Conductance Calcium-Activated Potassium Channel and Calcium Homeostasis in Vascular Smooth Muscle Cells

In vitro cardiomyocyte differentiation of umbilical cord blood cells: crucial role for c-kit(+) cells.

Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification

The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons.

Regulatory effects of fibroblast growth factor-8 and tumor necrosis factor-a on osteoblast marker expression induced by bone morphogenetic protein-2.

Targeting CD20+ Aggressive B-cell Non-Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells In Vitro and in NSG Mice.

Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs