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Recognition determinants of broadly neutralizing human antibodies against dengue viruses.

Dengue disease is caused by four different flavivirus serotypes, which infect 390 million people yearly with 25% symptomatic cases and for which no licensed vaccine is available. Recent phase III vaccine trials showed partial protection, and in...

Authors: Rouvinski A, Guardado-Calvo P, Barba-Spaeth G, Duquerroy S, Vaney MC1, Kikuti CM, Navarro Sanchez...

SST Peer Reviewed

Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes.

The Transforming Growth Factor-ß (TGFß) family ligand Nodal is an essential embryonic morphogen that is associated with progression of breast and other cancers. It has therefore been suggested that Nodal inhibitors could be used to treat breast...

Authors: Aykul S1, Ni W1, Mutatu W1, Martinez-Hackert E1.

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors

Novel therapeutic approaches are urgently required for multiple myeloma (MM). We used a phenotypic screening approach using co-cultures of MM cells with bone marrow stromal cells to identify compounds that overcome stromal resistance. One such...

Authors: Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody...

SIRT1 inhibition affects angiogenic properties of human MSCs

Human mesenchymal stem cells (hMSCs) are attractive for clinical and experimental purposes due to their capability of self-renewal and of differentiating into several cell types. Autologous hMSCs transplantation has been proven to induce therapeutic...

Authors: Botti C, Caiafa I, Coppola A, Cuomo F, Miceli M, Altucci L, Cobellis G5.

ELMO1 Is Upregulated in AML CD34+ Stem/Progenitor Cells, Mediates Chemotaxis and Predicts Poor Prognosis in Normal Karyotype AML

Both normal as well leukemic hematopoietic stem cells critically depend on their microenvironment in the bone marrow for processes such as self-renewal, survival and differentiation, although the exact pathways that are involved remain poorly...

Authors: Capala ME, Vellenga E, Schuringa JJ

SST Peer Reviewed

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons

Small-conductance Ca(2+)-activated K(+) channel activation is an emerging therapeutic approach for treatment of neurological diseases, including stroke, amyotrophic lateral sclerosis and schizophrenia. Our previous studies showed that activation of...

Authors: Dolga AM1, de Andrade A2, Meissner L3, Knaus HG4, Höllerhage M5, Christophersen P6, Zischka H7,...

Allosteric and hyperekplexic mutant phenotypes investigated on an a1 glycine receptor transmembrane structure.

The glycine receptor (GlyR) is a pentameric ligand-gated ion channel (pLGIC) mediating inhibitory transmission in the nervous system. Its transmembrane domain (TMD) is the target of allosteric modulators such as general anesthetics and ethanol and is...

Authors: Moraga-Cid G, Sauguet L, Huon C, Malherbe L, Girard-Blanc C, Petres S, Murail S, Taly A, Baaden M,...

SST Peer Reviewed

Peptide Immunization Against ERG and Immunogenic Mutations to Treat Prostate Cancer

The hormonal milieu influences immune tolerance as well as the immune response against viruses and cancer, but the direct effect of androgens on cellular immunity remains largely uncharacterized. We therefore sought to evaluate the effect of...

Authors: Haydn T Kissick

CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo

Mammalian spermatogenesis is a highly regulated multistage process of sperm generation. It is hard to uncover the real function of a testis specific gene in vitro since the in vitro model is not yet mature. With the development of the CRISPR/Cas9...

Authors: Li M, Huang R, Jiang X, Chen Y, Zhang Z, Zhang X, Liang P, Zhan S, Cao S, Songyang Z, Huang J.

SST Peer Reviewed

Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression

The REIC/Dkk-3 gene has been reported to be a tumor suppressor and the expression is significantly down-regulated in a broad range of cancer cell types. The protein is secretory, but the physiological function remains unclear. This study demonstrated...

Authors: Watanabe M, Kashiwakura Y, Huang P, Ochiai K, Futami J, Li SA, Takaoka M, Nasu Y, Sakaguchi M, Huh...

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Recognition determinants of broadly neutralizing human antibodies against dengue viruses.

Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes.

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors

SIRT1 inhibition affects angiogenic properties of human MSCs

ELMO1 Is Upregulated in AML CD34+ Stem/Progenitor Cells, Mediates Chemotaxis and Predicts Poor Prognosis in Normal Karyotype AML

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons

Allosteric and hyperekplexic mutant phenotypes investigated on an a1 glycine receptor transmembrane structure.

Peptide Immunization Against ERG and Immunogenic Mutations to Treat Prostate Cancer

CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo

Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression