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Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome

COVID-19 is associated with lymphopenia and ‘cytokine storm’, but no information is available on specific cellular immune responses to SARS-CoV-2. Here, wecharacterized SARS-CoV-2-specific CD4+ and CD8+ T-cells in patients with acute respiratory...

Authors: Daniela Weiskopf, Katharina S. Schmitz, Matthijs P. Raadsen, Alba Grifoni, Nisreen M.A. Okba, Henrik...

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1–4. Previous studies have shown that some bat...

Authors: Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo...

SST Peer Reviewed

The Replication of a Mouse Adapted SARS-CoV in a Mouse Cell Line Stably Expressing the Murine SARS-CoV Receptor mACE2 Efficiently Induces the Expression of Proinflammatory Cytokines

Infection of conventional mice with a mouse adapted (MA15) severe acute respiratory syndrome (SARS) coronavirus (CoV) reproduces many aspects of human SARS such as pathological changes in lung, viremia, neutrophilia, and lethality. However,...

Authors: Jose A Regla-Nava 1 , Jose M Jimenez-Guardeño, Jose L Nieto-Torres, Thomas...

SST Peer Reviewed

Adiponectin Reduces Bone Stiffness: Verified in a Three-Dimensional Artificial Human Bone Model In Vitro.

Primary human osteoblasts and osteoclasts incubated in a rotating coculture system without any scaffolding material, form bone-like tissue that may be used to evaluate effects of various compounds on mechanical strength. Circulating adiponectin has...

Authors: Haugen S, He J, Sundaresan A, Stunes AK, Aasarød KM, Tiainen H, Syversen U, Skallerud B, Reseland...

Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes

The RNA-synthesizing machinery of the severe acute respiratory syndrome Coronavirus (SARS-CoV) is composed of 16 non-structural proteins (nsp1–16) encoded by ORF1a/1b. The 148-amino acid nsp10 subunit contains two zinc fingers and is known to...

Authors: Mickaël Bouvet,‡§,1,2 Adrien Lugari,¶,1,3 Clara C. Posthuma, Jessika C. Zevenhoven,? Stéphanie...

SST Peer Reviewed

RUNX1 regulates site specificity of DNA demethylation by recruitment of DNA demethylation machineries in hematopoietic cells

RUNX1 is an essential master transcription factor in hematopoietic development and plays important roles in immune functions. Although the gene regulatory mechanism of RUNX1 has been characterized extensively, the epigenetic role of RUNX1 remains...

Authors: Suzuki T, Shimizu Y, Furuhata E, Maeda S, Kishima M, Nishimura H, Enomoto S, Hayashizaki Y, Suzuki...

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health emergency. Cell entry of coronaviruses depends on binding of the viral spike (S) proteins to...

Authors: Markus Hoffmann 1 , Hannah Kleine-Weber 2...

SST Peer Reviewed

Adapting tissue-engineered in vitro CNS models for high-throughput study of neurodegeneration

Neurodegenerative conditions remain difficult to treat, with the continuing failure to see therapeutic research successfully advance to clinical trials. One of the obstacles that must be overcome is to develop enhanced models of disease. Tissue...

Authors: O'Rourke C, Lee-Reeves C, Drake RA, Cameron GW, Loughlin AJ, Phillips JB.

Phosphatidylethanolamine and Phosphatidylcholine Biosynthesis by the Kennedy Pathway Occurs at Different Sites in Trypanosoma Brucei

Phosphatidylethanolamine (PE) and phosphatidylcholine (PC) are among the most abundant phospholipids in biological membranes. In many eukaryotes, the CDP-ethanolamine and CDP-choline branches of the Kennedy pathway represent major and often essential...

Authors: Luce Farine 1 , Moritz Niemann 3 , André...

SST Peer Reviewed

SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems

One of the greatest threats to humanity is the emergence of a pandemic virus. Among those with the greatest potential for such an event include influenza viruses and coronaviruses. In the last century alone, we have observed four major influenza A...

Authors: Daniel Blanco-Melo, Benjamin E. Nilsson-Payant, Wen-Chun Liu, Rasmus Møller, Maryline Panis, David...

SST Peer Reviewed

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Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome

A pneumonia outbreak associated with a new coronavirus of probable bat origin

The Replication of a Mouse Adapted SARS-CoV in a Mouse Cell Line Stably Expressing the Murine SARS-CoV Receptor mACE2 Efficiently Induces the Expression of Proinflammatory Cytokines

Adiponectin Reduces Bone Stiffness: Verified in a Three-Dimensional Artificial Human Bone Model In Vitro.

Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes

RUNX1 regulates site specificity of DNA demethylation by recruitment of DNA demethylation machineries in hematopoietic cells

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Adapting tissue-engineered in vitro CNS models for high-throughput study of neurodegeneration

Phosphatidylethanolamine and Phosphatidylcholine Biosynthesis by the Kennedy Pathway Occurs at Different Sites in Trypanosoma Brucei

SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems