Search Results

Novel roles of focal adhesion kinase in cytoplasmic entry and replication of influenza A viruses

Viruses modulate cellular signaling pathways at almost every step of the infection cycle. Cellular signaling pathways activated at later times of influenza infection have previously been investigated; however, early influenza virus-host cell...

Authors: Elbahesh H, Cline T, Baranovich T, Govorkova EA, Schultz-Cherry S, Russell CJ

Quantification of proteome changes in bovine muscle from two-dimensional electrophoresis data

Proteome changes in the longissimus thoracis bovine muscle in response to pre-slaughter stress were assessed on the basis of two-dimensional electrophoresis (2-DE) data. In this study, the bootstrap resampling statistical technique and a new measure...

Authors: Franco D, Mato A, Salgado FJ, López-Pedrouso M, Carrera M, Bravo S, Parrado M, Gallardo JM, Zapata...

In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment

We have succeeded in developing hollow branching structure in vitro commonly observed in lung airway using primary lung airway epithelial cells. Cell concentration gradient is the key factor that determines production of the branching cellular...

Authors: Hagiwara M, Peng F, Ho CM

SST Peer Reviewed

ON01210.Na (Ex-RADH) Mitigates Radiation Damage through Activation of the AKT Pathway

Development of radio-protective agents that are non-toxic is critical in light of ever increasing threats associated with proliferation of nuclear materials, terrorism and occupational risks associated with medical and space exploration. In this...

Authors: Anthony D. Kang, Stephen C. Cosenza,Marie Bonagura,Manoj Manair,M. V. Ramana Reddy, E. Premkumar...

Cytotoxic Effects during Knock Out of Multiple Porcine Endogenous Retrovirus (PERV) Sequences in the Pig Genome by Zinc Finger Nucleases (ZFN)

Xenotransplantation has been proposed as a solution to the shortage of suitable human donors for transplantation and pigs are currently favoured as donor animals. However, xenotransplantation may be associated with the transmission of zoonotic...

Authors: Semaan M, Ivanusic D, Denner J.

SST Peer Reviewed

The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein.

BACKGROUND: Deoxyuridine 5'-triphosphate nucleotide-hydrolases (dUTPases) are essential for maintaining low intra-cellular dUTP/dTTP ratios. Therefore, many viruses encode this enzyme to prevent dUTP incorporation into their genomes instead of...

Authors: Voronin N, Herzig E, Hizi A1.

Melanocortins Contribute to Sequential Differentiation and Enucleation of Human Erythroblasts via Melanocortin Receptors 1, 2 and 5

In this study, we showed that adrenocorticotropic hormone (ACTH) promoted erythroblast differentiation and increased the enucleation ratio of erythroblasts. Because ACTH was contained in hematopoietic medium as contamination, the ratio decreased by...

Authors: Eriko Simamura1, Tomohiro Arikawa2, Takayuki Ikeda, Hiroki Shimada, Hiroki Shoji, Hiroko Masuta,...

Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area.

BACKGROUND: Exposure to coarse, fine, and ultrafine particles is associated with adverse population health impacts. We investigated whether size-fractionated particles collected repeatedly in the vicinity of industrial (steel mills and associated...

Authors: Thomson EM1, Breznan D2, Karthikeyan S3, MacKinnon-Roy C4, Charland JP5, Dabek-Zlotorzynska E6, Celo...

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

Clinical-grade T cells are genetically modified ex vivo to express a chimeric antigen receptor (CAR) to redirect specificity to a tumor associated antigen (TAA) thereby conferring antitumor activity in vivo. T cells expressing a CD19-specific CAR...

Authors: Torikai H, Reik A, Liu PQ, Zhou Y, Zhang L, Maiti S, Huls H, Miller JC, Kebriaei P, Rabinovitch B,...

SST Peer Reviewed

Biomedical Application of Low Molecular Weight Heparin/Protamine Nano/Micro Particles as Cell- and Growth Factor-Carriers and Coating Matrix

Low molecular weight heparin (LMWH)/protamine (P) nano/micro particles (N/MPs) (LMWH/P N/MPs) were applied as carriers for heparin-binding growth factors (GFs) and for adhesive cells including adipose-derived stromal cells (ADSCs) and bone...

Authors: Ishihara M, Kishimoto S, Takikawa M, Hattori H, Nakamura S, Shimizu M.

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Novel roles of focal adhesion kinase in cytoplasmic entry and replication of influenza A viruses

Quantification of proteome changes in bovine muscle from two-dimensional electrophoresis data

In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment

ON01210.Na (Ex-RADH) Mitigates Radiation Damage through Activation of the AKT Pathway

Cytotoxic Effects during Knock Out of Multiple Porcine Endogenous Retrovirus (PERV) Sequences in the Pig Genome by Zinc Finger Nucleases (ZFN)

The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein.

Melanocortins Contribute to Sequential Differentiation and Enucleation of Human Erythroblasts via Melanocortin Receptors 1, 2 and 5

Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area.

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

Biomedical Application of Low Molecular Weight Heparin/Protamine Nano/Micro Particles as Cell- and Growth Factor-Carriers and Coating Matrix