Search Results

Novel roles of focal adhesion kinase in cytoplasmic entry and replication of influenza A viruses

Viruses modulate cellular signaling pathways at almost every step of the infection cycle. Cellular signaling pathways activated at later times of influenza infection have previously been investigated; however, early influenza virus-host cell...

Authors: Elbahesh H, Cline T, Baranovich T, Govorkova EA, Schultz-Cherry S, Russell CJ

In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment

We have succeeded in developing hollow branching structure in vitro commonly observed in lung airway using primary lung airway epithelial cells. Cell concentration gradient is the key factor that determines production of the branching cellular...

Authors: Hagiwara M, Peng F, Ho CM

SST Peer Reviewed

The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein.

BACKGROUND: Deoxyuridine 5'-triphosphate nucleotide-hydrolases (dUTPases) are essential for maintaining low intra-cellular dUTP/dTTP ratios. Therefore, many viruses encode this enzyme to prevent dUTP incorporation into their genomes instead of...

Authors: Voronin N, Herzig E, Hizi A1.

Regulatory effects of fibroblast growth factor-8 and tumor necrosis factor-a on osteoblast marker expression induced by bone morphogenetic protein-2.

BMP induces osteoblast differentiation, whereas a key proinflammatory cytokine, TNF-a, causes inflammatory bone damage shown in rheumatoid arthritis. FGF molecules are known to be involved in bone homeostasis. However, the effects of FGF-8 on...

Authors: Katsuyama T, Otsuka F, Terasaka T, Inagaki K, Takano-Narazaki M, Matsumoto Y, Sada KE, Makino H.

The Moraxella catarrhalis-induced pro-inflammatory immune response is enhanced by the activation of the epidermal growth factor receptor in human pulmonary epithelial cells

BACKGROUND: Chronic lower airway inflammation is considered to be a major cause of pathogenesis and disease progression in chronic obstructive pulmonary disease (COPD). Moraxella catarrhalis is a COPD-associated pathogen causing exacerbations and...

Authors: N\\\'Guessan PD, Haarmann H, Steiner T, Heyl K, Schreiber F, Heinrich A, Slevogt H

Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes.

Recently we identified multiple suramin-sensitivity genes with a genome wide screen in Trypanosoma brucei that includes the invariant surface glycoprotein ISG75, the adaptin-1 (AP-1) complex and two deubiquitylating enzymes (DUBs) orthologous to...

Authors: Zoltner M, Leung KF, Alsford S, Horn D, Field MC

SST Peer Reviewed

Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area.

BACKGROUND: Exposure to coarse, fine, and ultrafine particles is associated with adverse population health impacts. We investigated whether size-fractionated particles collected repeatedly in the vicinity of industrial (steel mills and associated...

Authors: Thomson EM1, Breznan D2, Karthikeyan S3, MacKinnon-Roy C4, Charland JP5, Dabek-Zlotorzynska E6, Celo...

Polymerase discordance in novel swine influenza H3N2v constellations is tolerated in swine but not human respiratory epithelial cells

Swine-origin H3N2v, a variant of H3N2 influenza virus, is a concern for novel reassortment with circulating pandemic H1N1 influenza virus (H1N1pdm09) in swine because this can lead to the emergence of a novel pandemic virus. In this study, the...

Authors: Powell JD, Dlugolenski D, Nagy T, Gabbard J, Lee C, Tompkins SM, Tripp RA

ROS detoxification and proinflammatory cytokines are linked by p38 MAPK signaling in a model of mature astrocyte activation.

Astrocytes are the most abundant glial cell in the retinal nerve fiber layer (NFL) and optic nerve head (ONH), and perform essential roles in maintaining retinal ganglion cell (RGC) detoxification and homeostasis. Mature astrocytes are relatively...

Authors: Nahirnyj A, Livne-Bar I, Guo X, Sivak J.

Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes.

The Transforming Growth Factor-ß (TGFß) family ligand Nodal is an essential embryonic morphogen that is associated with progression of breast and other cancers. It has therefore been suggested that Nodal inhibitors could be used to treat breast...

Authors: Aykul S1, Ni W1, Mutatu W1, Martinez-Hackert E1.

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