Search Results

Cigarette smoke activates the proto-oncogene c-src to promote airway inflammation and lung tissue destruction

Authors: Geraghty P, Hardigan A, Foronjy RF

The human macrophage sodium channel NaV1.5 regulates mycobacteria processing through organelle polarization and localized calcium oscillations

Phagocytosis and intracellular processing of mycobacteria by macrophages are complex cellular processes that require spatial and temporal coordination of particle uptake, organelle movement, activation of signaling pathways, and channel-mediated...

Authors: Carrithers LM, Hulseberg P, Sandor M, Carrithers MD

P2X4 Assembles with P2X7 and Pannexin-1 in Gingival Epithelial Cells and Modulates ATP-induced Reactive Oxygen Species Production and Inflammasome Activation

We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to activate an inflammasome and caspase-1, thereby inducing secretion of interleukin (IL)-1ß....

Authors: Shu-Chen Hung, Chul Hee Choi., Najwane Said-Sadier, Larry Johnson, Kalina Rosenova Atanasova, Hanen...

Inactivation of Endothelial Small/Intermediate Conductance of Calcium-Activated Potassium Channels Contributes to Coronary Arteriolar Dysfunction in Diabetic Patients

BACKGROUND: Diabetes is associated with coronary arteriolar endothelial dysfunction. We investigated the role of the small/intermediate (SK(Ca)/IK(Ca)) conductance of calcium-activated potassium channels in diabetes-related endothelial dysfunction....

Authors: Liu Y, Xie A, Singh AK, Ehsan A, Choudhary G, Dudley S, Sellke FW, Feng J

Physiologic Behavioural Changes of Precancerous Leukoplakia Cell lines Exerted to Extremely Low Frequency Electric Field

Objectives: Oral galvanism arising from the presence of two different metallic fillings in the mouth that may reach up to 16V/m, induces several changes in oral environment such as gingival swelling and erythema, mucosal pain, lichenoid reactions...

Authors: Ahmed Korraah, Margarete Odenthal, Marion Kopp, Nadarajah Vigneswaran, Peter G Sacks, Hans Peter...

Cytokine production by bone marrow mononuclear cells in inherited bone marrow failure syndromes

Fanconi anaemia (FA), dyskeratosis congenita (DC), Diamond-Blackfan anaemia (DBA), and Shwachman-Diamond syndrome (SDS) are characterized by the progressive development of bone marrow failure. Overproduction of tumour necrosis factor-a (TNF-a) from...

Authors: Matsui K, Giri N, Alter BP, Pinto LA

SST Peer Reviewed

Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia

Decreased autophagy contributes to malignancies; however, it is unclear how autophagy has an impact on tumor growth. Acute myeloid leukemia (AML) is an ideal model to address this as (i) patient samples are easily accessible, (ii) the hematopoietic...

Authors: Watson AS, Riffelmacher T, Stranks A, Williams O, De Boer J, Cain K, MacFarlane M, McGouran J,...

SST Peer Reviewed

A Comparative View on Easy to Deploy non-Integrating Methods for Patient-Specific iPSC Production.

Induced pluripotent stem cells (iPSCs) are routinely produced from dermal fibroblasts, with potential applications ranging from in vitro disease models to drug discovery and regenerative medicine. The need of eliminating the remaining reprogramming...

Authors: Manzini S, Viiri LE, Marttila S, Aalto-Setälä K

SST Peer Reviewed

Particle pollution in Rio de Janeiro, Brazil: Increase and decrease of pro-inflammatory cytokines IL-6 and IL-8 in human lung cells

Particle pollution from urban and industrialized regions in Rio de Janeiro (RJ), Brazil was analyzed for toxic and pro-inflammatory (cytokines: IL-6, IL-8, IL-10) responses in human bronchial epithelial cells. Trace elements contribution was studied....

Authors: Rosa I. Rodríguez-Cotto, Mario G. Ortiz-Martínez, Evasomary Rivera-Ramírez, Vinicius L. Mateus d,...

Global proteomic signature of undifferentiated human bone marrow stromal cells: evidence for donor-to-donor proteome heterogeneity

The clinical application of human bone marrow stromal cells (hBMSCs) largely depends on their capacity to expand in vitro. We have conducted a comprehensive comparative proteomic analysis of culture-expanded hBMSCs obtained from different human...

Authors: Mindaye ST, Ra M, Lo Surdo JL, Bauer SR, Alterman MA

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Cigarette smoke activates the proto-oncogene c-src to promote airway inflammation and lung tissue destruction

The human macrophage sodium channel NaV1.5 regulates mycobacteria processing through organelle polarization and localized calcium oscillations

P2X4 Assembles with P2X7 and Pannexin-1 in Gingival Epithelial Cells and Modulates ATP-induced Reactive Oxygen Species Production and Inflammasome Activation

Inactivation of Endothelial Small/Intermediate Conductance of Calcium-Activated Potassium Channels Contributes to Coronary Arteriolar Dysfunction in Diabetic Patients

Physiologic Behavioural Changes of Precancerous Leukoplakia Cell lines Exerted to Extremely Low Frequency Electric Field

Cytokine production by bone marrow mononuclear cells in inherited bone marrow failure syndromes

Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia

A Comparative View on Easy to Deploy non-Integrating Methods for Patient-Specific iPSC Production.

Particle pollution in Rio de Janeiro, Brazil: Increase and decrease of pro-inflammatory cytokines IL-6 and IL-8 in human lung cells

Global proteomic signature of undifferentiated human bone marrow stromal cells: evidence for donor-to-donor proteome heterogeneity