Search Results

Nuclease-mediated double-strand break (DSB) enhancement of small fragment homologous recombination (SFHR) gene modification in human-induced pluripotent stem cells (hiPSCs).

Recent developments in methods to specifically modify genomic DNA using sequence-specific endonucleases and donor DNA have opened the door to a new therapeutic paradigm for cell and gene therapy of inherited diseases. Sequence-specific endonucleases,...

Authors: Sargent RG, Suzuki S, Gruenert DC.

SST Peer Reviewed

Tight junction disruption by cadmium in an in vitro human airway tissue model

BACKGROUND: The cadmium (Cd) present in air pollutants and cigarette smoke has the potential of causing multiple adverse health outcomes involving damage to pulmonary and cardiovascular tissue. Injury to pulmonary epithelium may include alterations...

Authors: Cao X, Lin H, Muskhelishvili L, Latendresse J, Richter P, Heflich RH

Genetic analysis of the endemic fungal pathogens Coccidioides posadasii and Coccidioides immitis in Mexico

Coccidioidomycosis (CM) is a mycotic disease that affects mammals, including humans. Official data relative to CM in Mexico has not been collected since 1995, thus its prevalence remains unknown. The objectives of this study were to identify the...

Authors: Luna-Isaac JA, Muñiz-Salazar R, Baptista-Rosas RC, Enríquez-Paredes LM, Castañón-Olivares LR,...

Restoration of desmosomal junction protein expression and inhibition of H3K9-specific histone demethylase activity by cytostatic proline-rich polypeptide-1 leads to suppression of tumorigenic potential in human chondrosarcoma cells

Disruption of cell-cell junctions and the concomitant loss of polarity, downregulation of tumor-suppressive adherens junctions and desmosomes represent hallmark phenotypes for several different cancer cells. Moreover, a variety of evidence supports...

Authors: Galoian K, Qureshi A, Wideroff G, Temple HT

Human induced pluripotent stem cells are capable of B-cell lymphopoiesis

Induced pluripotent stem (iPS) cells offer a unique potential for understanding the molecular basis of disease and development. Here we have generated several human iPS cell lines, and we describe their pluripotent phenotype and ability to...

Authors: Lee Carpenter, Ram Malladi, Cheng-Tao Yang, Anna French, Katherine J. Pilkington, Richard W....

SST Peer Reviewed

Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists

Toll-like receptor (TLR) agonists activate both the innate and the adaptive immune systems. These TLR agonists have been exploited as potent vaccine adjuvants and antitumor agents. We describe the identification and characterization of a small...

Authors: Cheng K, Gao M, Godfroy JI, Brown PN, Kastelowitz N, Yin H

Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M

Glucocorticoids are among the most commonly used anti-inflammatory agents. Despite the enormous efforts in elucidating the glucocorticoid-mediated anti-inflammatory actions, how glucocorticoids tightly control overactive inflammatory response is not...

Authors: Miyata M, Lee JY, Susuki-Miyata S, Wang WY, Xu H, Kai H, Kobayashi KS, Flavell RA, Li JD

Bone marrow-derived CMPs and GMPs represent highly functional proangiogenic cells: implications for ischemic cardiovascular disease

Clinical studies using bone marrow-derived proangiogenic cells (PACs) have demonstrated modest improvements of function and/or perfusion of ischemic myocardium or skeletal muscle. Because the identities of these PACs and their functional ability to...

Authors: Wara AK, Croce K, Foo S, Sun X, Icli B, Tesmenitsky Y, Esen F, Rosenzweig A, Feinberg MW.

SST Peer Reviewed

Quantification of proteome changes in bovine muscle from two-dimensional electrophoresis data

Proteome changes in the longissimus thoracis bovine muscle in response to pre-slaughter stress were assessed on the basis of two-dimensional electrophoresis (2-DE) data. In this study, the bootstrap resampling statistical technique and a new measure...

Authors: Franco D, Mato A, Salgado FJ, López-Pedrouso M, Carrera M, Bravo S, Parrado M, Gallardo JM, Zapata...

The hormone melatonin stimulates renoprotective effects of “early outgrowth” endothelial progenitor cells in acute ischemic kidney injury

Endothelial progenitor cells (EPCs) protect the kidney from acute ischemic injury. The aim of this study was to analyze whether pretreatment of murine "early outgrowth" EPCs (eEPCs) with the hormone melatonin increases the cells' renoprotective...

Authors: D. Patschan, A. Hildebrandt, J. Rinneburger, J. T. Wessels, S. Patschan, J. U. Becker, E. Henze, A....

SST Peer Reviewed

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Nuclease-mediated double-strand break (DSB) enhancement of small fragment homologous recombination (SFHR) gene modification in human-induced pluripotent stem cells (hiPSCs).

Tight junction disruption by cadmium in an in vitro human airway tissue model

Genetic analysis of the endemic fungal pathogens Coccidioides posadasii and Coccidioides immitis in Mexico

Restoration of desmosomal junction protein expression and inhibition of H3K9-specific histone demethylase activity by cytostatic proline-rich polypeptide-1 leads to suppression of tumorigenic potential in human chondrosarcoma cells

Human induced pluripotent stem cells are capable of B-cell lymphopoiesis

Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists

Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M

Bone marrow-derived CMPs and GMPs represent highly functional proangiogenic cells: implications for ischemic cardiovascular disease

Quantification of proteome changes in bovine muscle from two-dimensional electrophoresis data

The hormone melatonin stimulates renoprotective effects of “early outgrowth” endothelial progenitor cells in acute ischemic kidney injury