Search Results

Analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host

Bats of different species play a major role in the emergence and transmission of highly pathogenic viruses including Ebola virus, SARS-like coronavirus and the henipaviruses. These viruses require proteolytic activation of surface envelope...

Authors: El Najjar F, Lampe L, Baker ML, Wang LF, Dutch RE

SST Peer Reviewed

Apolipoprotein B48, the Structural Component of Chylomicrons, Is Sufficient to Antagonize Staphylococcus aureus Quorum-Sensing

Serum lipoproteins (LP) are increasingly being recognized as dual purpose molecules that contribute to both cholesterol homeostasis and host innate defense. In fact, very low LP levels are associated with increased risk of bacterial infection in...

Authors: Elmore BO, Triplett KD, Hall PR

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion.

The protozoan Leishmania mexicana parasite causes chronic non-healing cutaneous lesions in humans and mice with poor parasite control. The mechanisms preventing the development of a protective immune response against this parasite are unclear. Here...

Authors: Hurrell BP, Schuster S, Grün E, Coutaz M, Williams RA, Held W, Malissen B, Malissen M, Yousefi S,...

SST Peer Reviewed

Cysteamine (Lynovex®), a novel mucoactive antimicrobial & antibiofilm agent for the treatment of cystic fibrosis

BACKGROUND: There remains a critical need for more effective, safe, long-term treatments for cystic fibrosis (CF). Any successful therapeutic strategy designed to combat the respiratory pathology of this condition must address the altered lung...

Authors: Charrier C, Rodger C, Robertson J, Kowalczuk A, Shand N, Fraser-Pitt D, Mercer D, O'Neil D

A Plasmodium phospholipase is involved in disruption of the liver stage parasitophorous vacuole membrane.

The coordinated exit of intracellular pathogens from host cells is a process critical to the success and spread of an infection. While phospholipases have been shown to play important roles in bacteria host cell egress and virulence, their role in...

Authors: Burda PC, Roelli MA, Schaffner M, Khan SM, Janse CJ, Heussler VT

SST Peer Reviewed

CILAIR-Based Secretome Analysis of Obese Visceral and Subcutaneous Adipose Tissues Reveals Distinctive ECM Remodeling and Inflammation Mediators

In the context of obesity, strong evidences support a distinctive pathological contribution of adipose tissue depending on its anatomical site of accumulation. Therefore, subcutaneous adipose tissue (SAT) has been lately considered metabolically...

Authors: Roca-Rivada A, Belen Bravo S, Pérez-Sotelo D, Alonso J, Castro AI, Baamonde I, Baltar J, Casanueva...

Refining the balance of attenuation and immunogenicity of respiratory syncytial virus by targeted codon deoptimization of virulence genes

Respiratory syncytial virus (RSV) is the most important pathogen for lower respiratory tract illness in children for which there is no licensed vaccine. Live-attenuated RSV vaccines are the most clinically advanced in children, but achieving an...

Authors: Meng J, Lee S, Hotard AL, Moore ML

The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel

In glaucoma, aqueous outflow into the Schlemm's canal (SC) is obstructed. Despite striking structural and functional similarities with the lymphatic vascular system, it is unknown whether the SC is a blood or lymphatic vessel. Here, we demonstrated...

Authors: Aspelund A, Tammela T, Antila S, Nurmi H, Leppänen VM, Zarkada G, Stanczuk L, Francois M, Mäkinen T,...

Nerve growth factor reduces amiloride-sensitive Na+ transport in human airway epithelial cells

Nerve growth factor (NGF) is overexpressed in patients with inflammatory lung diseases, including virus infections. Airway surface liquid (ASL), which is regulated by epithelial cell ion transport, is essential for normal lung function. No...

Authors: Shimko MJ, Zaccone EJ, Thompson JA, Schwegler-Berry D, Kashon ML, Fedan JS

Large genomic fragment deletions and insertions in mouse using CRISPR/Cas9.

ZFN, TALENs and CRISPR/Cas9 system have been used to generate point mutations and large fragment deletions and insertions in genomic modifications. CRISPR/Cas9 system is the most flexible and fast developing technology that has been extensively used...

Authors: Zhang L, Jia R, Palange NJ, Satheka AC, Togo J, An Y2, Humphrey M, Ban L, Ji Y, Jin H2, Feng X,...

SST Peer Reviewed

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Analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host

Apolipoprotein B48, the Structural Component of Chylomicrons, Is Sufficient to Antagonize Staphylococcus aureus Quorum-Sensing

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion.

Cysteamine (Lynovex®), a novel mucoactive antimicrobial & antibiofilm agent for the treatment of cystic fibrosis

A Plasmodium phospholipase is involved in disruption of the liver stage parasitophorous vacuole membrane.

CILAIR-Based Secretome Analysis of Obese Visceral and Subcutaneous Adipose Tissues Reveals Distinctive ECM Remodeling and Inflammation Mediators

Refining the balance of attenuation and immunogenicity of respiratory syncytial virus by targeted codon deoptimization of virulence genes

The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel

Nerve growth factor reduces amiloride-sensitive Na+ transport in human airway epithelial cells

Large genomic fragment deletions and insertions in mouse using CRISPR/Cas9.