Search Results

Automated microscopy as a quantitative method to measure differences in adipogenic differentiation in preparations of human mesenchymal stromal cells

BACKGROUND AIMS: Multipotent stromal cells, also called mesenchymal stromal cells (MSCs), are potentially valuable as a cellular therapy because of their differentiation and immunosuppressive properties. As the result of extensive heterogeneity of...

Authors: Lo Surdo JL, Millis BA, Bauer SR

Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke

Background: Only a few exposure systems are presently available that enable cigarette smoke exposure of living cells at the air–liquid interface, of which one of the most versatile is the Vitrocell® system (Vitrocell® Systems GmbH). To assess its...

Authors: Shoaib Majeed, Stefan Frentzel, Sandra Wagner, Diana Kuehn, Patrice Leroy, Philippe A Guy, Arno...

Dietary Tocotrienol/?-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice.

Brain aging is accompanied by a decrease in mitochondrial function. In vitro studies suggest that tocotrienols, including ?- and d-tocotrienol (T3), may exhibit neuroprotective properties. However, little is known about the effect of dietary T3 on...

Authors: Schloesser A1, Esatbeyoglu T1, Piegholdt S1, Dose J1, Ikuta N2, Okamoto H3, Ishida Y3, Terao K4,...

Gene markers of cellular aging in human multipotent stromal cells in culture

NTRODUCTION: Human multipotent stromal cells (MSCs) isolated from bone marrow or other tissue sources have great potential to treat a wide range of injuries and disorders in the field of regenerative medicine and tissue engineering. In particular,...

Authors: Bellayr IH, Catalano JG, Lababidi S, Yang AX, Lo Surdo JL, Bauer SR, Puri RK

Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells

PURPOSE: The lung is one of the most common sites of breast cancer metastasis. While metastatic seeding is often accompanied by a dormancy-promoting mesenchymal to epithelial reverting transitions (MErT), we aimed to determine whether lung...

Authors: Furukawa M, Wheeler S, Clark AM, Wells A

SST Peer Reviewed

Immunogenicity and protective efficacy of Salmonella enterica serovar Pullorum pathogenicity island 2 mutant as a live attenuated vaccine candidate.

BACKGROUND: Salmonella enterica serovar Pullorum (S. Pullorum) causes Pullorum disease (PD), a severe systemic disease of poultry and results in considerable economic losses in developing countries. In order to develop a safe and immunogenic...

Authors: Yin J1, Cheng Z1, Xu L1, Li Q1, Geng S1, Pan Z1, Jiao X2

Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers

Tumor development is a complex and dynamic process that involves malignant, vascular, and stromal cells. Endosialin is a tumor endothelial marker (TEM) present in the microvasculature and stroma of human tumors. Cancer-associated fibroblasts (CAF)...

Authors: Bagley RG, Weber W, Rouleau C, Yao M, Honma N, Kataoka S, Ishida I, Roberts BL, Teicher BA.

Analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host

Bats of different species play a major role in the emergence and transmission of highly pathogenic viruses including Ebola virus, SARS-like coronavirus and the henipaviruses. These viruses require proteolytic activation of surface envelope...

Authors: El Najjar F, Lampe L, Baker ML, Wang LF, Dutch RE

SST Peer Reviewed

Use of Genome Engineering to Create Patient Specific MLL Translocations in Primary Human Hematopoietic Stem and Progenitor Cells.

One of the challenging questions in cancer biology is how a normal cell transforms into a cancer cell. There is strong evidence that specific chromosomal translocations are a key element in this transformation process. Our studies focus on...

Authors: Breese EH, Buechele C, Dawson C, Cleary ML, Porteus MH.

SST Peer Reviewed

Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p

microRNAs (miRNAs) are abundantly expressed in development where they are critical determinants of cell differentiation and phenotype. Accordingly miRNAs are essential for normal skeletal development and chondrogenesis in particular. However, the...

Authors: Barter MJ, Tselepi M, Gómez R, Woods S, Hui W, Smith GR, Shanley DP, Clark IM, Young DA.

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin

Automated microscopy as a quantitative method to measure differences in adipogenic differentiation in preparations of human mesenchymal stromal cells

Characterization of the Vitrocell® 24/48 in vitro aerosol exposure system using mainstream cigarette smoke

Dietary Tocotrienol/?-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice.

Gene markers of cellular aging in human multipotent stromal cells in culture

Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells

Immunogenicity and protective efficacy of Salmonella enterica serovar Pullorum pathogenicity island 2 mutant as a live attenuated vaccine candidate.

Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers

Analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host

Use of Genome Engineering to Create Patient Specific MLL Translocations in Primary Human Hematopoietic Stem and Progenitor Cells.

Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p