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Paracrine induction of endothelium by tumor exosomes

Cancers use a nanoscale messenger system known as exosomes to communicate with surrounding tissues and immune cells. However, the functional relationship between tumor exosomes, endothelial signaling, angiogenesis, and metastasis is poorly...

Authors: Joshua L. Hood, Hua Pan, Gregory M. Lanza and Samuel A. Wickline

Improving Viability and Transfection Efficiency with Human Umbilical Cord Wharton 's Jelly Cells Through Use of a ROCK Inhibitor

Differentiating stem cells using gene delivery is a key strategy in tissue engineering and regenerative medicine applications. Nonviral gene delivery bypasses several safety concerns associated with viral gene delivery; however, leading nonviral...

Authors: Mellott AJ, Godsey ME, Shinogle HE, Moore DS, Forrest ML, Detamore MS.

Safety assessment of potential food ingredients in canine hepatocytes

This research aimed to develop in vitro methods to assess hazard of canine food ingredients. Canine hepatocytes were harvested and cell viability of clove-leaf oil (CLO), eugenol (EUG), lemongrass oil (LGO), guanosine monophosphate (GMP), inosine...

Authors: Zhang LW, Koci J, Jeffery B2, Riviere JE, Monteiro-Riviere NA

BAC-based cellular model for screening regulators of BDNF gene transcription.

BACKGROUND: Brain derived neurotrophic factor (BDNF) belongs to a family of structurally related proteins called neurotrophins that have been shown to regulate survival and growth of neurons in the developing central and peripheral nervous system...

Authors: Jaanson K1, Sepp M, Aid-Pavlidis T, Timmusk T.

Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin.

Polymorphous low-grade adenocarcinoma (PLGA) and cribriform adenocarcinoma of minor salivary gland (CAMSG) are low-grade carcinomas arising most often in oral cavity and oropharynx, respectively. Controversy exists as to whether these tumors...

Authors: Weinreb I, Zhang L, Tirunagari LM, Sung YS, Chen CL, Perez-Ordonez B, Clarke BA, Skalova A, Chiosea...

GABA blocks pathological but not acute TRPV1 pain signals.

Sensitization of the capsaicin receptor TRPV1 is central to the initiation of pathological forms of pain, and multiple signaling cascades are known to enhance TRPV1 activity under inflammatory conditions. How might detrimental escalation of TRPV1...

Authors: Hanack C, Moroni M, Lima WC, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A,...

SST Peer Reviewed

Development of a high-throughput cell-based assay for identification of IL-17 inhibitors

Human interleukin 17 (IL-17) is a proinflammatory cytokine derived mainly from activated T cells. Extensive evidence points to a significant role of IL-17 in many autoimmune and infectious diseases, as well as tumorigenesis and transplant rejection,...

Authors: Dobritsa SV, Kuok IT, Nguyen H, Webster JC, Spragg AM, Morley T, Carr GJ.

Association of enhanced HIV-1 neutralization by a single Y681H substitution in gp41 with increased gp120-CD4 interaction and macrophage infectivity

HIV-1 variants that show unusual sensitivity to autologous antibodies due to presence of critical neutralization signatures would likely contribute towards rational envelope based HIV-1 vaccine design. In the present study, we found that presence of...

Authors: Ringe R, Bhattacharya J

Genetic transformation of an obligate anaerobe, P. gingivalis for FMN-green fluorescent protein expression in studying host-microbe interaction.

The recent introduction of "oxygen-independent" flavin mononucleotide (FMN)-based fluorescent proteins (FbFPs) is of major interest to both eukaryotic and prokaryotic microbial biologists. Accordingly, we demonstrate for the first time that an...

Authors: Choi CH, DeGuzman JV, Lamont RJ, Yilmaz Ö.

Harnessing high density lipoproteins to block transforming growth factor beta and to inhibit the growth of liver tumor metastases

Transforming growth factor ß (TGF-ß) is a powerful promoter of cancer progression and a key target for antitumor therapy. As cancer cells exhibit active cholesterol metabolism, high density lipoproteins (HDLs) appear as an attractive delivery system...

Authors: Medina-Echeverz J1, Fioravanti J1, Díaz-Valdés N2, Frank K3, Aranda F1, Gomar C1, Ardaiz N1, Dotor...

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