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SIRT1 inhibition affects angiogenic properties of human MSCs

Human mesenchymal stem cells (hMSCs) are attractive for clinical and experimental purposes due to their capability of self-renewal and of differentiating into several cell types. Autologous hMSCs transplantation has been proven to induce therapeutic...

Authors: Botti C, Caiafa I, Coppola A, Cuomo F, Miceli M, Altucci L, Cobellis G5.

The effects of inflammatory cytokines on lymphatic endothelial barrier function

Proper lymphatic function is necessary for the transport of fluids, macromolecules, antigens and immune cells out of the interstitium. The lymphatic endothelium plays important roles in the modulation of lymphatic contractile activity and lymph...

Authors: Cromer WE, Zawieja SD, Tharakan B, Childs EW, Newell MK, Zawieja DC.

Type 1 Diabetes Prone NOD Mice Have Diminished Cxcr1 mRNA Expression in Polymorphonuclear Neutrophils and CD4+ T Lymphocytes

In humans, CXCR1 and CXCR2 are two homologous proteins that bind ELR+ chemokines. Both receptors play fundamental roles in neutrophil functions such as migration and reactive oxygen species production. Mouse Cxcr1 and Cxcr2 genes are located in an...

Authors: Karine Haurogné, Marija Pavlovic, Hélène Rogniaux, Jean-Marie Bach, Blandine Lieubeau

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons

Small-conductance Ca(2+)-activated K(+) channel activation is an emerging therapeutic approach for treatment of neurological diseases, including stroke, amyotrophic lateral sclerosis and schizophrenia. Our previous studies showed that activation of...

Authors: Dolga AM1, de Andrade A2, Meissner L3, Knaus HG4, Höllerhage M5, Christophersen P6, Zischka H7,...

BMP-2 induces a profibrotic phenotype in adult renal progenitor cells through Nox4 activation.

Adult renal progenitor cells (ARPCs) isolated from the human kidney may contribute to repair featuring acute kidney injury (AKI). Bone morphogenetic proteins (BMPs) regulate differentiation, modeling, and regeneration processes in several tissues....

Authors: Simone S, Cosola C, Loverre A, Cariello M, Sallustio F, Rascio F, Gesualdo L, Schena FP, Grandaliano...

A Screen for Short-Range Paracrine Interactions

Conventional methods for studying paracrine signaling in vitro may not be sensitive to short-range effects resulting from signal dilution or decay. We employ a microfabricated culture substrate to maintain two cell populations in microscale...

Authors: Spencer KH, Kim MY, Hughes CC, Hui EE.

3,3\\\'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells.

We recently reported that novel ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells. In this paper, we have focused on the mechanism(s) associated...

Authors: Goldberg AA1, Draz H2, Montes-Grajales D3, Olivero-Verbél J3, Safe SH4, Sanderson JT5

Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration in mice.

Nogo-B, also known as reticulon 4B, promotes liver fibrosis and cirrhosis by facilitating the transforming growth factor ß (TGF-ß) signaling pathway in activated hepatic stellate cells. The aim of this study was to determine the role of Nogo-B in...

Authors: Gao L, Utsumi T, Tashiro K, Liu B, Zhang D, Swenson ES, Iwakiri Y.

The role of Src family kinases in growth and migration of glioma stem cells.

Src family kinases (SFKs) are highly expressed and active in clinical glioblastoma multiforme (GBM) specimens. SFKs inhibitors have been demonstrated to inhibit proliferation and migration of glioma cells. However, the role of SFKs in glioma stem...

Authors: Han X1, Zhang W1, Yang X1, Wheeler CG1, Langford CP2, Wu L1, Filippova N1, Friedman GK3, Ding Q4,...

Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes

The establishment of self-renewing hepatoblast-like cells (HBCs) from human pluripotent stem cells (PSCs) would realize a stable supply of hepatocyte-like cells for medical applications. However, the functional characterization of human PSC-derived...

Authors: Takayama K1, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, Hayakawa T, Kawabata K,...

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