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Cross-protection against Salmonella Typhimurium infection conferred by a live attenuated Salmonella Enteritidis vaccine

In this study, a genetically engineered live attenuated Salmonella Enteritidis (SE) vaccine was evaluated for its ability to protect against Salmonella Typhimurium (ST) infection in chickens. The birds were orally primed with the vaccine on the 1st...

Authors: Nandre RM1, Lee D1, Lee JH1

Human platelet lysate is a feasible candidate to replace fetal calf serum as medium supplement for blood vascular and lymphatic endothelial cells

BACKGROUND AIMS: As angiogenic and lymphangiogenic key players, endothelial cells (ECs) are promising candidates for vascular regenerative therapies. To culture ECs in vitro, fetal calf serum (FCS) is most often used. However, some critical...

Authors: Hofbauer P, Riedl S, Witzeneder K, Hildner F3, Wolbank S, Groeger M, Gabriel C, Redl H, Holnthoner...

The effects of inflammatory cytokines on lymphatic endothelial barrier function

Proper lymphatic function is necessary for the transport of fluids, macromolecules, antigens and immune cells out of the interstitium. The lymphatic endothelium plays important roles in the modulation of lymphatic contractile activity and lymph...

Authors: Cromer WE, Zawieja SD, Tharakan B, Childs EW, Newell MK, Zawieja DC.

FGF-dependent regulation of VEGF receptor 2 expression in mice

Numerous studies have suggested a link between the angiogenic FGF and VEGF signaling pathways; however, the nature of this link has not been established. To evaluate this relationship, we investigated VEGF signaling in ECs with disrupted FGF...

Authors: MurakamiMurakami M, Nguyen LT, Hatanaka K, Schachterle W, Chen PY, Zhuang ZW, Black BL, Simons M M1,...

Rosmarinic acid and arbutin suppress osteoclast differentiation by inhibiting superoxide and NFATc1 downregulation in RAW 264.7 cells

The present study investigated the effect of the natural polyphenols, rosmarinic acid and arbutin, on osteoclast differentiation in RAW 264.7 cells. Rosmarinic acid and arbutin suppressed osteoclast differentiation and had no cytotoxic effect on...

Authors: Omori A1, Yoshimura Y1, Deyama Y1, Suzuki K1.

A Screen for Short-Range Paracrine Interactions

Conventional methods for studying paracrine signaling in vitro may not be sensitive to short-range effects resulting from signal dilution or decay. We employ a microfabricated culture substrate to maintain two cell populations in microscale...

Authors: Spencer KH, Kim MY, Hughes CC, Hui EE.

Muscle side population cells from dystrophic or injured muscle adopt a fibro-adipogenic fate

Muscle side population (SP) cells are rare multipotent stem cells that can participate in myogenesis and muscle regeneration upon transplantation. While they have been primarily studied for the development of cell-based therapies for Duchenne...

Authors: Penton CM, Thomas-Ahner JM, Johnson EK, McAllister C, Montanaro F

Paracrine induction of endothelium by tumor exosomes

Cancers use a nanoscale messenger system known as exosomes to communicate with surrounding tissues and immune cells. However, the functional relationship between tumor exosomes, endothelial signaling, angiogenesis, and metastasis is poorly...

Authors: Joshua L. Hood, Hua Pan, Gregory M. Lanza and Samuel A. Wickline

Dietary Tocotrienol/?-Cyclodextrin Complex Increases Mitochondrial Membrane Potential and ATP Concentrations in the Brains of Aged Mice.

Brain aging is accompanied by a decrease in mitochondrial function. In vitro studies suggest that tocotrienols, including ?- and d-tocotrienol (T3), may exhibit neuroprotective properties. However, little is known about the effect of dietary T3 on...

Authors: Schloesser A1, Esatbeyoglu T1, Piegholdt S1, Dose J1, Ikuta N2, Okamoto H3, Ishida Y3, Terao K4,...

Improving Viability and Transfection Efficiency with Human Umbilical Cord Wharton 's Jelly Cells Through Use of a ROCK Inhibitor

Differentiating stem cells using gene delivery is a key strategy in tissue engineering and regenerative medicine applications. Nonviral gene delivery bypasses several safety concerns associated with viral gene delivery; however, leading nonviral...

Authors: Mellott AJ, Godsey ME, Shinogle HE, Moore DS, Forrest ML, Detamore MS.

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