Search Results

Mesenchymal stem cell-tumor cell cooperation in breast cancer vasculogenesis

Mesenchymal stem cells (MSCs) are able to acquire endothelial-like characteristics but their involvement in regulating MSC vasculogenesis is more complex. MSCs are able to express endothelial markers when cultured in endothelial growth medium (EGM),...

Authors: SERBAN COMSA, FELICIA CIUCULESCU and MARIUS RAICA

SST Peer Reviewed

Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells.

NTRODUCTION: Unrestricted somatic stem cells (USSC) derived from umbilical cord blood are an attractive alternative to human embryonic stem cells (hESC) for cellular therapy. USSC are capable of forming cells representative of all three germ line...

Authors: Filby CE, Williamson R, van Kooy P, Pébay A, Dottori M, Elwood NJ, Zaibak F.

Differentiation of human hair follicle stem cells into endothelial cells induced by vascular endothelial and basic fibroblast growth factors

Hair follicle stem cells (HFSCs) possess powerful expansion and multi-differentiation potential, properties that place them at the forefront of the field of tissue engineering and stem cell-based therapy. The aim of the present study was to...

Authors: ZHI CHENG XU, QUN ZHANG and HONG LI

SST Peer Reviewed

Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds.

Identification of appropriate donor cell types is important for lung cell therapy and for lung regeneration. Previous studies have indicated that mesenchymal stromal cells derived from human bone marrow (hBM-MSCs) and from human adipose tissue...

Authors: Mendez JJ, Ghaedi M, Steinbacher D, Niklason LE.

Cyclooxygenase inhibition improves endothelial vasomotor dysfunction of visceral adipose arterioles in human obesity

OBJECTIVE: The purpose of this study was to determine whether cyclooxygenase inhibition improves vascular dysfunction of adipose microvessels from obese humans. DESIGN AND METHODS: In 20 obese subjects (age 37 ± 12 years, BMI 47 ± 8...

Authors: Farb MG, Tiwari S, Karki S, Ngo DT, Carmine B, Hess DT, Zuriaga MA, Walsh K, Fetterman JL, Hamburg...

Corneal Regeneration by Deep Anterior Lamellar Keratoplasty (DALK) Using Decellularized Corneal Matrix

The purpose of this study is to demonstrate the feasibility of DALK using a decellularized corneal matrix obtained by HHP methodology. Porcine corneas were hydrostatically pressurized at 980 MPa at 10°C for 10 minutes to destroy the cells, followed...

Authors: Hashimoto Y, Funamoto S, Sasaki S, Negishi J, Honda T, Hattori S, Nam K, Kimura T, Mochizuki M,...

SST Peer Reviewed

Monocyte interaction accelerates HCl-induced lung epithelial remodeling.

BACKGROUND: Acute respiratory distress syndrome (ARDS) is characterized by overwhelming inflammatory responses and lung remodeling. We hypothesized that leukocyte infiltration during the inflammatory response modulates epithelial remodeling through...

Authors: Chen Q, Luo AA, Qiu H, Han B, Ko BH, Slutsky AS, Zhang H

ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells.

Transplantation of endothelial cells (ECs) is a promising therapeutic approach for ischemic disorders. In addition, the generation of ECs has become increasingly important for providing vascular plexus to regenerated organs, such as the liver....

Authors: Morita R, Suzuki M, Kasahara H, Shimizu N, Shichita T, Sekiya T, Kimura A, Sasaki K, Yasukawa H,...

Harnessing high density lipoproteins to block transforming growth factor beta and to inhibit the growth of liver tumor metastases

Transforming growth factor ß (TGF-ß) is a powerful promoter of cancer progression and a key target for antitumor therapy. As cancer cells exhibit active cholesterol metabolism, high density lipoproteins (HDLs) appear as an attractive delivery system...

Authors: Medina-Echeverz J1, Fioravanti J1, Díaz-Valdés N2, Frank K3, Aranda F1, Gomar C1, Ardaiz N1, Dotor...

Mechanisms of vasculogenesis in 3D fibrin matrices mediated by the interaction of adipose-derived stem cells and endothelial cells

Vascularization of tissue-engineered constructs is essential to provide sufficient nutrient supply and hemostasis after implantation into target sites. Co-cultures of adipose-derived stem cells (ASC) with outgrowth endothelial cells (OEC) in fibrin...

Authors: Rohringer S, Hofbauer P, Schneider KH, Husa AM, Feichtinger G, Peterbauer-Scherb A, Redl H,...

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Mesenchymal stem cell-tumor cell cooperation in breast cancer vasculogenesis

Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells.

Differentiation of human hair follicle stem cells into endothelial cells induced by vascular endothelial and basic fibroblast growth factors

Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds.

Cyclooxygenase inhibition improves endothelial vasomotor dysfunction of visceral adipose arterioles in human obesity

Corneal Regeneration by Deep Anterior Lamellar Keratoplasty (DALK) Using Decellularized Corneal Matrix

Monocyte interaction accelerates HCl-induced lung epithelial remodeling.

ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells.

Harnessing high density lipoproteins to block transforming growth factor beta and to inhibit the growth of liver tumor metastases

Mechanisms of vasculogenesis in 3D fibrin matrices mediated by the interaction of adipose-derived stem cells and endothelial cells