Search Results

Apoptotic cells promote macrophage survival by releasing the anti-apoptotic mediator sphingosine-1-phosphate

Programmed cell death is vital for a number of pathophysiologic settings. Apoptotic cells are rapidly engulfed by phagocytes (ie, macrophages), which in turn acquire an anti-inflammatory phenotype known as alternative activation or the M2-type. Here...

Authors: Weigert A, Johann AM, von Knethen A, Schmidt H, Geisslinger G, Brune B

Selection by flow-sorting of genetically transformed, GFP-expressing blood stages of the rodent malaria parasite, Plasmodium berghei

This protocol describes a methodology for the genetic transformation of the rodent malaria parasite Plasmodium berghei and the subsequent selection of transformed parasites expressing green fluorescent protein (GFP) by flow-sorting. It provides...

Authors: Janse CJ, Franke-Fayard B, Waters AP

SST Peer Reviewed

Identification of Interleukin-13 Receptor 2 Peptide Analogues Capable of Inducing Improved Antiglioma CTL Responses

Restricted and high-level expression of interleukin-13 receptor alpha2 (IL-13Ralpha2) in a majority of human malignant gliomas makes this protein an attractive vaccine target. We have previously described the identification of the...

Authors: Eguchi J, Hatano M, Nishimura F, Zhu X, Dusak JE, Sato H, Pollack IF, Storkus WJ, Okada H

EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ERM proteins

EWI-2 and EWI-F, two members of a novel subfamily of Ig proteins, are direct partners of tetraspanins CD9 (Tspan29) and CD81 (Tspan28). These EWI proteins contain a stretch of basic charged amino acids in their cytoplasmic domains that may act as...

Authors: Sala-Valdes M, Ursa A, Charrin S, Rubinstein E, Hemler ME, Sanchez-Madrid F, Yanez-Mo M

Anti-MCP-1 Gene Therapy Inhibits Vascular Smooth Muscle Cells Proliferation and Attenuates Vein Graft Thickening Both In Vitro and In Vivo

OBJECTIVE: Because late vein graft failure is caused by intimal hyperplasia (IH) and accelerated atherosclerosis, and these processes are thought to be inflammation driven, influx of monocytes is one of the first phenomena seen in IH, we would like...

Authors: Schepers A, Eefting D, Bonta PI, Grimbergen JM, de Vries MR, van Weel V, de Vries CJ, Egashira K,...

Class IA Phosphatidylinositide 3-Kinases, rather than p110, Regulate Formyl-Methionyl-Leucyl-Phenylalanine-Stimulated Chemotaxis and Superoxide Production in Differentiated Neutrophil-Like PLB-985 Cells

Class I PI3Ks, through the formation of phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P(3)), are thought of as essential elements of the neutrophil response to chemotactic factors. Moreover, the recent development of PI3K-deficient mice and...

Authors: Boulven I, Levasseur S, Marois S, Pare G, Rollet-Labelle E, Naccache PH

Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin

17-Allylamino-demethoxy geldanamycin (17-AAG) inhibits the chaperone association of heat shock protein 90 (hsp90) with the heat shock factor-1 (HSF-1), which induces the mRNA and protein levels of hsp70. Increased hsp70 levels inhibit death receptor...

Authors: Guo F, Rocha K, Bali P, Pranpat M, Fiskus W, Boyapalle S, Kumaraswamy S, Balasis M, Greedy B,...

MITF Interactions with 14-3-3 Modulate Differentiation of Committed Myeloid Precursors

The microphthalmia-associated transcription factor (MITF) is required for terminal osteoclast differentiation and is a target for signaling pathways engaged by colony stimulating factor (CSF)-1 and receptor-activator of nuclear factor-kappaB ligand...

Authors: Bronisz A, Sharma SM, Hu R, Godlewski J, Tzivion G, Mansky KC, Ostrowski MC

Biphasic regulation by bile acids of dermal fibroblast proliferation through regulation of cAMP production and COX-2 expression level

We have previously reported that the bile acids chenodeoxycholate (CDCA), and ursodeoxycholate (UDCA), decreased PGE1-induced cAMP production not only in hepatocytes but also in non-hepatic cells including dermal fibroblasts. In the present study we...

Authors: Meng J, Ceryak S, Arastu Z, Jones L, Epstein L, Bouscarel B

Dysregulated T cell expression of TIM3 in multiple sclerosis

T cell immunoglobulin- and mucin domain-containing molecule (TIM)3 is a T helper cell (Th)1-associated cell surface molecule that regulates Th1 responses and promotes tolerance in mice, but its expression and function in human T cells is unknown. We...

Authors: Koguchi K, Anderson DE, Yang L, O'connor KC, Kuchroo VK, Hafler DA

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin