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Identification of proteins cleaved downstream of caspase activation in monocytes undergoing macrophage differentiation

We have shown previously that caspases were specifically involved in the differentiation of peripheral blood monocytes into macrophages while not required for monocyte differentiation into dendritic cells. To identify caspase targets in monocytes...
Authors: Cathelin S, Rebe C, Haddaoui L, Simioni N, Verdier F, Fontenay M, Launay S, Mayeux P, Solary E

The Unique IR2 Protein of Equine Herpesvirus 1 Negatively Regulates Viral Gene Expression

The IR2 protein (IR2P) is a truncated form of the immediate-early protein (IEP) lacking the essential acidic transcriptional activation domain (TAD) and serine-rich tract and yet retaining binding domains for DNA and TFIIB and nuclear localization...
Authors: Kim SK, Ahn BC, Albrecht RA, O'callaghan DJ

Recombinant Ig-Like Transcript 3-Fc Modulates T Cell Responses via Induction of Th Anergy and Differentiation of CD8+ T Suppressor Cells

The Ig-like transcript (ILT)3 is crucial to the tolerogenic activity acquired by dendritic cells exposed to allospecific T suppressor (Ts) cells. We have explored the immunomodulatory property of the extracellular region of ILT3 using a cytoplasmic...
Authors: Kim-Schulze S, Scotto L, Vlad G, Piazza F, Lin H, Liu Z, Cortesini R, Suciu-Foca N

Distinct Roles of Nonmuscle Myosin II Isoforms in the Regulation of MDA-MB-231 Breast Cancer Cell Spreading and Migration

Initial stages of tumor cell metastasis involve an epithelial-mesenchyme transition that involves activation of amoeboid migration and loss of cell-cell adhesion. The actomyosin cytoskeleton has fundamental but poorly understood roles in these...
Authors: Betapudi V, Licate LS, Egelhoff TT

A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation

Chronic myeloid leukemia (CML) is characterized by the presence of the constitutively active BCR-ABL protein tyrosine kinase. Using a multipotent hemopoietic cell line, FDCP-Mix, expressing BCR-ABL tyrosine kinase, we investigated the initial effects...
Authors: McCallum L, Price S, Planque N, Perbal B, Pierce A, Whetton AD, Irvine AE

Transcriptional Regulation of Lung Cytidylyltransferase in Developing Transgenic Mice

Lung development is associated with a surge in surfactant phosphatidylcholine (PC) production to prepare the newborn for extrauterine breathing. This process is associated with a marked increase in the activity of the rate-regulatory surfactant...
Authors: McCoy DM, Fisher K, Robichaud J, Ryan AJ, Mallampalli RK

cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein

NMDA receptor-dependent long-term potentiation and long-term depression (LTD) involve changes in AMPA receptor activity and postsynaptic localization that are in part controlled by glutamate receptor 1 (GluR1) subunit phosphorylation. The scaffolding...
Authors: Smith KE, Gibson ES, Dell'Acqua ML

Nucleophosmin is essential for ribosomal protein L5 nuclear export

Nucleophosmin (NPM/B23) is a key regulator in the regulation of a number of processes including centrosome duplication, maintenance of genomic integrity, and ribosome biogenesis. While the mechanisms underlying NPM function are largely...
Authors: Yu Y, Maggi LB Jr, Brady SN, Apicelli AJ, Dai MS, Lu H, Weber JD

Cytoplasmic IRE1alpha -mediated XBP1 mRNA splicing in the absence of nuclear processing and ER stress

Accumulation of unfolded proteins in the endoplasmic reticulum activates an intracellular signal transduction program termed the Unfolded Protein Response (UPR). In mammalian cells, the UPR is signaled in part through dimerization of ER...
Authors: Back SH, Lee K, Vink E, Kaufman RJ

Nuclear localization in the biology of the CD40 receptor in normal and neoplastic human B lymphocytes

CD40 is a TNF receptor superfamily (TNRSF-5) member that initiates important signaling pathways mediating cell growth, survival and differentiation in B-lymphocytes. Although CD40 has been extensively studied as a plasma membrane-associated growth...
Authors: Lin-Lee YC, Pham LV, Tamayo AT, Fu L, Zhou HJ, Yoshimura LC, Decker GL, Ford RJ
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