Search Results

Mitogen- and stress-activated protein kinase 1 is critical for interleukin-1-induced, CREB-mediated, c-fos gene expression in keratinocytes

c-fos, which encodes a transcription factor of the AP-1 family, is a prototypical immediate-early gene induced by a number of proinflammatory cytokines including interleukin-1 (IL-1), the latter being an important regulator of skin homeostasis. Using...

Authors: Schiller M, Bohm M, Dennler S, Ehrchen JM, Mauviel A

Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer

Mutations in Wnt pathway genes are rare in human breast cancer, yet activation of the pathway is evident from the misolocalization of beta-catenin. We searched for relationships in the expression of Wnt pathway genes and found that both secreted...

Authors: Shulewitz M, Soloviev I, Wu T, Koeppen H, Polakis P, Sakanaka C

Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion

Eph receptor tyrosine kinases regulate the spatial organization of cells within tissues. Central to this function is their ability to modulate cell shape and movement in response to stimulation by the ephrin ligands. The EphB2 receptor was reported...

Authors: Dail M, Richter M, Godement P, Pasquale EB

Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cells survival and migration

Neuropilin-2 (NRP-2) is a receptor for the Vascular Endothelial Growth Factor (VEGF) and the Semaphorin (Sema) families, two unrelated ligand families involved in angiogenesis and neuronal guidance. NRP-2 binds specifically VEGF-A and VEGF-C, however...

Authors: Favier B, Alam A, Barron P, Bonnin J, Laboudie P, Fons P, Mandron M, Herault JP, Neufeld G, Savi P,...

Antigen targeting to endosomal pathway in dendritic cell vaccination activates regulatory T cells and attenuates tumor-immunity

Lymphoma cells are malignant cells of the T- or B-cell lineage which often express many surface markers inappropriately, yet are not recognized as abnormal by the immune system. We modeled this situation by inoculating ovalbumin-expressing E.G7-OVA...

Authors: Maksimow M, Miiluniemi M, Marttila-Ichihara F, Jalkanen S, Hanninen A

FOG-1 represses GATA-1-dependent FcRI -chain transcription: transcriptional mechanism of mast cell-specific gene expression in mice

Cell-type specific transcription of mouse high-affinity IgE receptor (FcepsilonRI) beta-chain is positively regulated by the transcription factor, GATA-1. Although GATA-1 is expressed in erythroid cells, megakaryocytes, and mast cells, the expression...

Authors: Maeda K, Nishiyama C, Tokura T, Nakano H, Kanada S, Nishiyama M, Okumura K, Ogawa H

Effects of dynactin disruption and Dynein depletion on axonal microtubules

We investigated potential roles of cytoplasmic dynein in organizing axonal microtubules either by depleting dynein heavy chain from cultured neurons or by experimentally disrupting dynactin. The former was accomplished by siRNA while the latter was...

Authors: Ahmad FJ, He Y, Myers KA, Hasaka TP, Francis F, Black MM, Baas PW

ATP binding to a unique site in the type-1 S2- Inositol 1,4,5-trisphosphate receptor defines susceptibility to phosphorylation by protein kinase A

The subtype and splice variant specific modulation of Inositol 1,4,5-trisphosphate receptors (InsP3R) by interaction with cellular factors plays a fundamental role in defining the characteristics of Ca2+ release in individual cell types. In this...

Authors: Wagner LE, Betzenhauser MJ, Yule DI

HIV-1 GP120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase, CD45

The molecular mechanism of human immunodeficiency virus type 1 (HIV-1 gp120)-induced apoptosis in bystander T cells is not well defined. Here, we demonstrate that CD45, a key component of the TCR (T cell receptor) pathway, plays a crucial role in the...

Authors: Anand AR, Ganju RK

The High-Affinity Immunoglobulin-E Receptor (FcepsilonRI) is Endocytosed by an AP-2/Clathrin-Independent, Dynamin-Dependent Mechanism

Aggregation of the high-affinity immunoglobulin E (IgE) receptor (FcepsilonRI), expressed on mast cells and basophils, initiates the immediate hypersensitivity reaction. Aggregated FcepsilonRI has been reported to rapidly migrate to lipid rafts in...

Authors: Fattakhova G, Masilamani M, Borrego F, Gilfillan AM, Metcalfe DD, Coligan JE

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