Search Results

NOD-Rag2null IL-2R?null mice: an alternative to NOG mice for generation of humanized mice.

We have developed NOD-Rag2(null) IL-2R?(null) (NR2G) mice similar to NOD-scidIL-2R?(null) (NOG) mice that are known as an excellent host to generate humanized mice. To evaluate the usefulness of NR2G mice as a host for humanized mice, the engraftment...

Authors: Katano I, Ito R, Kamisako T, Eto T, Ogura T, Kawai K, Suemizu H, Takahashi T, Kawakami Y, Ito M

SST Peer Reviewed

Biliverdins regulation of reactive oxygen species signalling leads to potent inhibition of proliferative and angiogenic pathways in head and neck cancer.

BACKGROUND: In this study, we evaluate whether the use of biliverdin (BV), a natural non-toxic antioxidant product of haeme catabolism, can suppress head and neck squamous cell carcinoma (HNSCC) cell proliferation and improve the tumour survival both...

Authors: Zheng J, Nagda DA, Lajud SA, Kumar S, Mouchli A, Bezpalko O 'Malley BW Jr, Li D.

Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors.

The RUNX1/ETO (RE) fusion protein, which originates from the t(8;21) chromosomal rearrangement, is one of the most frequent translocation products found in de novo acute myeloid leukemia (AML). In RE leukemias, activated forms of the c-KIT tyrosine...

Authors: Wichmann C, Quagliano-Lo Coco I, Yildiz Ö, Chen-Wichmann L, Weber H, Syzonenko T, Döring C, Brendel...

SST Peer Reviewed

Immuno-modification of enhancing stem cells targeting for myocardial repair.

Despite the controversy in mechanism, rodent and clinical studies have demonstrated beneficial effects of stem/progenitor cell therapy after myocardial infarction (MI). In a rat ischaemic reperfusion MI model, we investigated the effects of...

Authors: Yu J, Wu YK, Gu Y, Fang Q, Sievers R, Ding CH, Olgin JE, Lee RJ

SST Peer Reviewed

CARDIOMYOGENIC DIFFERENTIATION OF FETAL DERIVED MESENCHYMAL STEM CELLS: A TRANSFORMATIVE APPROACH FOR CARDIAC TREATMENT

Authors: Shraddha Singh Gautam; Jaianand Kannaiyan

Biphasic Effects of Ingenol 3,20-Dibenzoate on the Erythropoietin Receptor: Synergism at Low Doses and Antagonism at High Doses.

Although ingenol 3,20-dibenzoate (IDB) is known as a selective novel protein kinase C (PKC) agonist, its biologic actions and underlying mechanisms remain incompletely understood. In this study, we identified IDB as a proliferative agent for an...

Authors: Oh JG, Chin YW, Kim SJ, Choi JM, Kim SK, Kang HE, Heo TH

SST Peer Reviewed

Therapeutic Benefit of Bone Marrow–Derived Endothelial Progenitor Cell Transplantation after Experimental Aneurysm Embolization with Coil in Rats

Aneurysm embolization with coil is now widely used clinically. However, the recurrence of aneurysms after embolization has always plagued neurosurgeons because the endothelial layer of the aneurysm neck loses its integrity after being embolized by...

Authors: Zhang S, An Q, Li Q, Huang J, Chen X, Chen X, Zhang J, Wang Y, Yang GY, Zhu W.

Interleukin-10 receptor-1 expression in monocyte-derived antigen-presenting cell populations: dendritic cells partially escape from IL-10\'s inhibitory mechanisms.

Interleukin (IL)-10 is an important immunoregulatory cytokine that mediates its effects via a transmembrane receptor complex consisting of two different chains, IL-10R1 and IL-10R2. While IL-10R2 is ubiquitously expressed and does not bind IL-10...

Authors: von Lanzenauer SH, Wolk K, Höflich C, Kunz S, Grünberg BH, Döcke WD, Reineke U, Asadullah K, Sterry...

SST Peer Reviewed

Mesenchymal stem cell-tumor cell cooperation in breast cancer vasculogenesis.

Mesenchymal stem cells (MSCs) are able to acquire endothelial-like characteristics but their involvement in regulating MSC vasculogenesis is more complex. MSCs are able to express endothelial markers when cultured in endothelial growth medium (EGM),...

Authors: Comsa S, Ciuculescu F, Raica M.

Isolation of prostate tumor initiating cells (TICs) through their dielectrophoretic signature.

In this study, the dielectrophoretic response of prostate tumor initiating cells (TICs) was investigated in a microfluidic system utilizing contactless dielectrophoresis (cDEP). The dielectrophoretic response of prostate TICs was observed to be...

Authors: Salmanzadeh A, Romero L, Shafiee H, Gallo-Villanueva RC, Stremler MA, Cramer SD, Davalos RV.

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NOD-Rag2null IL-2R?null mice: an alternative to NOG mice for generation of humanized mice.

Biliverdins regulation of reactive oxygen species signalling leads to potent inhibition of proliferative and angiogenic pathways in head and neck cancer.

Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors.

Immuno-modification of enhancing stem cells targeting for myocardial repair.

CARDIOMYOGENIC DIFFERENTIATION OF FETAL DERIVED MESENCHYMAL STEM CELLS: A TRANSFORMATIVE APPROACH FOR CARDIAC TREATMENT

Biphasic Effects of Ingenol 3,20-Dibenzoate on the Erythropoietin Receptor: Synergism at Low Doses and Antagonism at High Doses.

Therapeutic Benefit of Bone Marrow–Derived Endothelial Progenitor Cell Transplantation after Experimental Aneurysm Embolization with Coil in Rats

Interleukin-10 receptor-1 expression in monocyte-derived antigen-presenting cell populations: dendritic cells partially escape from IL-10\'s inhibitory mechanisms.

Mesenchymal stem cell-tumor cell cooperation in breast cancer vasculogenesis.

Isolation of prostate tumor initiating cells (TICs) through their dielectrophoretic signature.