Search Results

Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

The optimization of cell culture conditions for growth and productivity of recombinant Chinese hamster ovary (CHO) cells is a critical step in biopharmaceutical manufacturing. In the present study, the effects of the timing and amount of peptone...

Authors: Davami F, Baldi L, Rajendra Y, M Wurm F

Engineered composite tissue as a bioartificial limb graft.

The loss of an extremity is a disastrous injury with tremendous impact on a patient's life. Current mechanical prostheses are technically highly sophisticated, but only partially replace physiologic function and aesthetic appearance. As a biologic...

Authors: Jank BJ, Xiong L, Moser PT, Guyette JP, Ren X, Cetrulo CL, Leonard DA, Fernandez L, Fagan SP, Ott...

SST Peer Reviewed

Electrophysiological characterization of activation state-dependent Cav2 channel antagonist TROX-1 in spinal nerve injured rats.

Prialt, a synthetic version of Cav2.2 antagonist ?-conotoxin MVIIA derived from Conus magus, is the first clinically approved voltage-gated calcium channel blocker for refractory chronic pain. However, due to the narrow therapeutic window and...

Authors: Patel R, Rutten K, Valdor M, Schiene K, Wigge S, Schunk S, Damann N, Christoph T, Dickenson AH3

SST Peer Reviewed

Benchmarking of commercially available CHO cell culture media for antibody production

In this study, eight commercially available, chemically defined Chinese hamster ovary (CHO) cell culture media from different vendors were evaluated in batch culture using an IgG-producing CHO DG44 cell line as a model. Medium adaptation revealed...

Authors: Reinhart D1 Damjanovic L, Kaisermayer C, Kunert R

Resistin-like molecule-ß is a human airway remodelling mediator.

Though implicated in vascular remodelling, a role for the resistin-like molecule (RELM)-ß in human airway remodelling remains unexplored. We hypothesised that RELM-ß expression is increased in the airways of asthmatics and regulates airways...

Authors: Fang C, Meng Q, Wu H, Eid G, Zhang G, Zhang X, Yang S, Huang K, Lee TH, Corrigan CJ, Ying S.

Characterization of age-related changes of tendon stem cells from adult human tendons.

PURPOSE: The present study evaluated the presence of stem cells in hamstring tendons from adult subjects of different ages. The aim was to isolate, characterize and expand these cells in vitro, and to evaluate whether cell activities are influenced...

Authors: Ruzzini L, Abbruzzese F, Rainer A, Longo UG, Trombetta M, Maffulli N, Denaro V

SST Peer Reviewed

Allogeneic mesenchymal precursor cell therapy to limit remodeling after myocardial infarction: the effect of cell dosage

BACKGROUND: This experiment assessed the dose-dependent effect of a unique allogeneic STRO-3-positive mesenchymal precursor cell (MPC) on postinfarction left ventricular (LV) remodeling. The MPCs were administered in a manner that would simulate...

Authors: Hamamoto H, Gorman JH 3rd, Ryan LP, Hinmon R, Martens TP, Schuster MD, Plappert T, Kiupel M, St...

Inner dynein arm defects causing primary ciliary dyskinesia: repeat testing required.

Primary ciliary dyskinesia (PCD) results in chronic nasal symptoms and chest disease leading to bronchiectasis. We noted a number of patients referred for diagnostic testing whose initial results suggested PCD due to an inner dynein arm or radial...

Authors: C. O’Callaghan, A. Rutman, G.M. Williams and R.A. Hirst

Characterization of the CD14++CD16+ monocyte population in human bone marrow.

Numerous studies have divided blood monocytes according to their expression of the surface markers CD14 and CD16 into following subsets: classical CD14(++)CD16(-), intermediate CD14(++)CD16(+) and nonclassical CD14(+)CD16(++) monocytes. These subsets...

Authors: Mandl M, Schmitz S, Weber C, Hristov M

SST Peer Reviewed

Transcription factor induction of human oligodendrocyte progenitor fate and differentiation

Human oligodendrocyte progenitor cell (OPC) specification and differentiation occurs slowly and limits the potential for cell-based treatment of demyelinating disease. In this study, using FACS-based isolation and microarray analysis, we identified a...

Authors: Wang 1, Pol SU, Haberman AK, Wang C, O\\\'Bara MA, Sim FJ

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Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells

Engineered composite tissue as a bioartificial limb graft.

Electrophysiological characterization of activation state-dependent Cav2 channel antagonist TROX-1 in spinal nerve injured rats.

Benchmarking of commercially available CHO cell culture media for antibody production

Resistin-like molecule-ß is a human airway remodelling mediator.

Characterization of age-related changes of tendon stem cells from adult human tendons.

Allogeneic mesenchymal precursor cell therapy to limit remodeling after myocardial infarction: the effect of cell dosage

Inner dynein arm defects causing primary ciliary dyskinesia: repeat testing required.

Characterization of the CD14++CD16+ monocyte population in human bone marrow.

Transcription factor induction of human oligodendrocyte progenitor fate and differentiation