Search Results

Statins impair glucose uptake in human cells.

OBJECTIVE: Considering the increasing number of clinical observations indicating hyperglycemic effects of statins, this study was designed to measure the influence of statins on the uptake of glucose analogs by human cells derived from liver, adipose...

Authors: Nowis D, Malenda A, Furs K, Oleszczak B, Sadowski R, Chlebowska J, Firczuk M, Bujnicki JM, Staruch...

SST Peer Reviewed

Identification of differentially expressed genes in human mesenchymal stem cell-derived neurons.

Mesenchymal stem cells (MSCs) have greater potential for immediate clinical and toxicological applications, due to their ability to self-renew, proliferate, and differentiate into a variety of cell types. To identify novel candidate genes that were...

Authors: Heo JH, Cho KJ, Choi DW, Kim SW

SST Peer Reviewed

25 years of African trypanosome research: From description to molecular dissection and new drug discovery

The Molecular Parasitology conference was first held at the Marine Biological laboratory, Woods Hole, USA 25 years ago. Since that first meeting, the conference has evolved and expanded but has remained the showcase for the latest research...

Authors: Matthews KR1.

SST Peer Reviewed

Human dental pulp stem cells (hDPSCs): isolation, enrichment and comparative differentiation of two sub-populations

BACKGROUND: Human dental pulp represents a suitable alternative source of stem cells for the purpose of cell-based therapies in regenerative medicine, because it is relatively easy to obtain it, using low invasive procedures. This study...

Authors: Pisciotta A1, Carnevale G2, Meloni S3, Riccio M4, De Biasi S5, Gibellini L6, Ferrari A7, Bruzzesi...

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

RNA-guided engineered nucleases (RGENs) derived from the prokaryotic adaptive immune system known as CRISPR (clustered, regularly interspaced, short palindromic repeat)/Cas (CRISPR-associated) enable genome editing in human cell lines, animals, and...

Authors: Kim S, Kim D, Cho SW, Kim J, Kim JS

SST Peer Reviewed

Ascorbic acid is a dose-dependent inhibitor of adipocyte differentiation, probably by reducing cAMP pool

Ascorbic acid (AA) is the active component of vitamin C and antioxidant activity was long considered to be the primary molecular mechanism underlying the physiological actions of AA. We recently demonstrated that AA is a competitive inhibitor of...

Authors: Rahman F1, Al Frouh F1, Bordignon B1, Fraterno M2, Landrier JF1, Peiretti F1, Fontes M1

Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9

Genome editing via CRISPR/Cas9 has rapidly become the tool of choice by virtue of its efficacy and ease of use. However, CRISPR/Cas9-mediated genome editing in clinically relevant human somatic cells remains untested. Here, we report CRISPR/Cas9...

Authors: Mandal PK, Ferreira LM, Collins R, Meissner TB, Boutwell CL, Friesen M, Vrbanac V, Garrison BS,...

SST Peer Reviewed

Antenatal glucocorticoid therapy accelerates ATP production with creatine kinase increase in the growth-enhanced fetal rat heart

BACKGROUND: Previous study has demonstrated the increase of several cardiac function-related proteins, including creatine kinase (CK) as an important enzyme in the process of ATP synthesis in the fetal heart of rats administered glucocorticoid...

Authors: Mizuno M, Takeba Y, Matsumoto N, Tsuzuki Y, Asoh K, Takagi M, Kobayashi S, Yamamoto H

SST Peer Reviewed

Defining suitable reference genes for RT-qPCR analysis on human sertoli cells after 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure.

Quantitative real-time RT-PCR (qPCR) has proven to be a valuable molecular technique to quantify gene expression. There are few studies in the literature that describe suitable reference genes to normalize gene expression data. Studies of...

Authors: Ribeiro MA, dos Reis MB, de Moraes LN, Briton-Jones C, Rainho CA, Scarano WR

SST Peer Reviewed

A Polymer-based Piezoelectric Transducer for Real-time Monitoring Contractile Behavior of Cardiomyocytes

In this paper, we present an intelligent piezoelectric transducer that can automatically monitor the contractile behavior of cardiomyocytes for the application of drug screening. By integrating a biomimetic substrate and a piezoelectric smart...

Authors: Hsu1 YH, Shen JW, Lin YH

SST Peer Reviewed

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Research Area

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Topic

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Characteristic

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Origin

Statins impair glucose uptake in human cells.

Identification of differentially expressed genes in human mesenchymal stem cell-derived neurons.

25 years of African trypanosome research: From description to molecular dissection and new drug discovery

Human dental pulp stem cells (hDPSCs): isolation, enrichment and comparative differentiation of two sub-populations

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

Ascorbic acid is a dose-dependent inhibitor of adipocyte differentiation, probably by reducing cAMP pool

Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9

Antenatal glucocorticoid therapy accelerates ATP production with creatine kinase increase in the growth-enhanced fetal rat heart

Defining suitable reference genes for RT-qPCR analysis on human sertoli cells after 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure.

A Polymer-based Piezoelectric Transducer for Real-time Monitoring Contractile Behavior of Cardiomyocytes