Search Results

A CRISPR/Cas9-based system for reprogramming cell lineage specification

Gene activation by the CRISPR/Cas9 system has the potential to enable new approaches to science and medicine, but the technology must be enhanced to robustly control cell behavior. We show that the fusion of two transactivation domains to Cas9...

Authors: Chakraborty S, Ji H1, Kabadi AM2, Gersbach CA3, Christoforou N4, Leong KW5.

A systematic evaluation of integration free reprogramming methods for deriving clinically relevant patient specific induced pluripotent stem (iPS) cells

A systematic evaluation of three different methods for generating induced pluripotent stem (iPS) cells was performed using the same set of parental cells in our quest to develop a feeder independent and xeno-free method for somatic cell reprogramming...

Authors: Goh PA, Caxaria S, Casper C, Rosales C, Warner TT, Coffey PJ, Nathwani AC

SST Peer Reviewed

The TRPM8 Protein Is a Testosterone Receptor: II. FUNCTIONAL EVIDENCE FOR AN IONOTROPIC EFFECT OF TESTOSTERONE ON TRPM8

Testosterone is a key steroid hormone in the development of male reproductive tissues and the regulation of the central nervous system. The rapid signaling mechanism induced by testosterone affects numerous behavioral traits, including sexual drive,...

Authors: Asuthkar S, Demirkhanyan L, Sun X, Elustondo PA, Krishnan V, Baskaran P, Velpula KK, Thyagarajan B,...

Nanog Overexpression Increases Neural Marker Expression in Adipose Derived Stem Cells

Human neural stem cells (hNSCs) have shown potential in treating a variety of neurological diseases. However, they are impractical to isolate and use for an autologous transplant, generating demand for an alternative source of neural phenotypes....

Authors: Kimmel J, Sugaya K

SST Peer Reviewed

Capsaicin from chili ( Capsicum spp.) inhibits vascular smooth muscle cell proliferation

Accelerated vascular smooth muscle cell (VSMC) proliferation is implied in cardiovascular disease and significantly contributes to vessel lumen reduction following surgical interventions such as percutaneous transluminal coronary angioplasty or...

Authors: Liu R, Heiss EH, Guo D, Dirsch VM, Atanasov AG2.

Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells

BACKGROUND: Liposarcomas are the most common class of soft tissue sarcomas, and myxoid liposarcoma is the second most common liposarcoma. EWSR1-DDIT3 is a chimeric fusion protein generated by the myxoid liposarcoma-specific chromosomal...

Authors: Suzuki K, Matsui Y, Higashimoto M, Kawaguchi Y, Seki S, Motomura H, Hori T, Yahara Y, Kanamori M,...

SST Peer Reviewed

Controlled Release of Dexamethasone in PCL/Silk Fibroin/Ascorbic Acid Nanoparticles for the Initiation of Adipose Derived Stem Cells into Osteogenesis

Mimicking hybrid extracellular matrix is one of the major challenges in bone tissue engineering. Biocomposite micro/nanoparticle of polycaprolactone (PCL), silk fibroin (SF), ascorbic acid (AA) and dexamethasone (DM) were fabricated by the...

Authors: Gandhimathi C, Edwin NXH, Jayaraman P, Venugopal JR, Ramakrishna S, Kuma SD

SST Peer Reviewed

Mesenchymal Stem Cells Conditioned Media Suppress Inflammation Associated Over-proliferation of Pulmonary Artery Smooth Muscle Cells in a Rat Model of Pulmonary Hypertension

Inflammation associated over-proliferation of pulmonary artery smooth muscle cells (PASMCs) is considered to be involved in the pathogenesis of pulmonary hypertension (PH). Even though administration of mesenchymal stem cells conditioned media...

Authors: Liu JF, Han Z, Han ZC, HeZX

SST Peer Reviewed

Potential of VEGF-encapsulated electrospun nanofibers for in vitro cardiomyogenic differentiation of human mesenchymal stem cells

Heart disease, especially myocardial infarction (MI), has become the leading cause of death all over the world, especially since the myocardium lacks the ability to regenerate after infarction. The capability of mesenchymal stem cells (MSCs) to...

Authors: Kai D, Prabhakaran MP, Jin G, Tian L, Ramakrishna S.

Platelet-rich plasma and adipose-derived mesenchymal stem cells for regenerative medicine-associated treatments in bottlenose dolphins (Tursiops truncatus).

Dolphins exhibit an extraordinary capacity to heal deep soft tissue injuries. Nevertheless, accelerated wound healing in wild or captive dolphins would minimize infection and other side effects associated with open wounds in marine animals. Here, we...

Authors: Griffeth RJ, García-Párraga D, Mellado-López M, Crespo-Picazo JL, Soriano-Navarro M4,...

SST Peer Reviewed

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A CRISPR/Cas9-based system for reprogramming cell lineage specification

A systematic evaluation of integration free reprogramming methods for deriving clinically relevant patient specific induced pluripotent stem (iPS) cells

The TRPM8 Protein Is a Testosterone Receptor: II. FUNCTIONAL EVIDENCE FOR AN IONOTROPIC EFFECT OF TESTOSTERONE ON TRPM8

Nanog Overexpression Increases Neural Marker Expression in Adipose Derived Stem Cells

Capsaicin from chili ( Capsicum spp.) inhibits vascular smooth muscle cell proliferation

Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells

Controlled Release of Dexamethasone in PCL/Silk Fibroin/Ascorbic Acid Nanoparticles for the Initiation of Adipose Derived Stem Cells into Osteogenesis

Mesenchymal Stem Cells Conditioned Media Suppress Inflammation Associated Over-proliferation of Pulmonary Artery Smooth Muscle Cells in a Rat Model of Pulmonary Hypertension

Potential of VEGF-encapsulated electrospun nanofibers for in vitro cardiomyogenic differentiation of human mesenchymal stem cells

Platelet-rich plasma and adipose-derived mesenchymal stem cells for regenerative medicine-associated treatments in bottlenose dolphins (Tursiops truncatus).