Search Results

Extrasynaptic glutamate NMDA receptors: Key players in striatal function.

N-methyl-d-aspartate receptors (NMDAR) are crucial for the function of excitatory neurotransmission and are present at the synapse and on the extrasynaptic membrane. The major nucleus of the basal ganglia, striatum, receives a large glutamatergic...

Authors: Garcia-Munoz M, Lopez-Huerta VG, Carrillo-Reid L, Arbuthnott GW

SST Peer Reviewed

Impaired osteoblast differentiation in annexin A2- and -A5-deficient cells

Annexins are a class of calcium-binding proteins with diverse functions in the regulation of lipid rafts, inflammation, fibrinolysis, transcriptional programming and ion transport. Within bone, they are well-characterized as components of...

Authors: Genetos DC1, Wong A1, Weber TJ2, Karin NJ2, Yellowley CE1

Single molecule analysis of Trypanosoma brucei DNA replication dynamics.

Eukaryotic genome duplication relies on origins of replication, distributed over multiple chromosomes, to initiate DNA replication. A recent genome-wide analysis of Trypanosoma brucei, the etiological agent of sleeping sickness, localized its...

Authors: Calderano SG, Drosopoulos WC, Quaresma MM, Marques CA, Kosiyatrakul S, McCulloch R, Schildkraut CL,...

Ischemic stroke brain sends indirect cell death signals to the heart.

BACKGROUND AND PURPOSE: Ischemic stroke is a leading cause of mortality and morbidity in the world and may be associated with cardiac myocyte vulnerability. However, it remains uncertain how an ischemic brain contributes to cardiac alternations....

Authors: Ishikawa H, Tajiri N, Vasconcellos J, Kaneko Y, Mimura O, Dezawa M, Borlongan CV

SST Peer Reviewed

Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol

Calcifying extracellular vesicles (EVs) released from cells within atherosclerotic plaques have received increased attention for their role in mediating vascular calcification, a major predictor of cardiovascular morbidity and mortality. However,...

Authors: Hutcheson JD1, Goettsch C1, Pham T1, Iwashita M1, Aikawa M1, Singh SA1, Aikawa E2

Survival, neuron-like differentiation and functionality of mesenchymal stem cells in neurotoxic environment: the critical role of erythropoietin.

Mesenchymal stem cells (MSCs) can ameliorate symptoms in several neurodegenerative diseases. However, the toxic environment of a degenerating central nervous system (CNS) characterized by hypoxia, glutamate (Glu) excess and amyloid beta (Abeta)...

Authors: Danielyan L, Schäfer R, Schulz A, Ladewig T, Lourhmati A, Buadze M, Schmitt AL, Verleysdonk S,...

SST Peer Reviewed

‘Supermutators’ found amongst highly levofloxacin-resistant E. coli isolates: a rapid protocol for the detection of mutation sites

Fluoroquinolone resistance is gradually acquired through several mechanisms. In particular, chromosomal mutations in the genes encoding topoisomerases II and IV and increased expression of the multidrug efflux pump AcrAB-TolC are the most common...

Authors: Ahmed Abdel-Fattah Zayed, Tamer Mohamed Essam, Abdel-Gawad Mohamed Hashem and Ossama Mohamed...

Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis.

INTRODUCTION: Since the concept of reprogramming mature somatic cells to generate induced pluripotent stem cells (iPSCs) was demonstrated in 2006, iPSCs have become a potential substitute for embryonic stem cells (ESCs) given their pluripotency...

Authors: Lee J, Kim Y, Yi H, Diecke S, Kim J, Jung H, Rim YA, Jung SM, Kim M, Kim YG, Park SH, Kim HY, Ju JH

Comparison of proliferative and multilineage differentiation potentials of cord matrix, cord blood, and bone marrow mesenchymal stem cells.

BACKGROUND: Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are the two widely studied and characterized adult stem cells. Thus far, MSCs were obtained from the bone marrow, which is a painful procedure. Therefore, MSCs from...

Authors: Shetty P, Cooper K, Viswanathan C

SST Peer Reviewed

Development and characterization of chloroplast microsatellite markers in a fine-leaved fescue, Festuca rubra (Poaceae).

PREMISE OF THE STUDY: Chloroplast microsatellite markers were developed for Festuca rubra to examine its population genetic characteristics, taxonomy, and coevolution with its endophyte Epichloë festucae. • METHODS AND RESULTS: Thirteen...

Authors: von Cräutlein M, Korpelainen H, Helander M, Väre H, Saikkonen K.

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Extrasynaptic glutamate NMDA receptors: Key players in striatal function.

Impaired osteoblast differentiation in annexin A2- and -A5-deficient cells

Single molecule analysis of Trypanosoma brucei DNA replication dynamics.

Ischemic stroke brain sends indirect cell death signals to the heart.

Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol

Survival, neuron-like differentiation and functionality of mesenchymal stem cells in neurotoxic environment: the critical role of erythropoietin.

‘Supermutators’ found amongst highly levofloxacin-resistant E. coli isolates: a rapid protocol for the detection of mutation sites

Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis.

Comparison of proliferative and multilineage differentiation potentials of cord matrix, cord blood, and bone marrow mesenchymal stem cells.

Development and characterization of chloroplast microsatellite markers in a fine-leaved fescue, Festuca rubra (Poaceae).