Search Results

Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells

BACKGROUND: Liposarcomas are the most common class of soft tissue sarcomas, and myxoid liposarcoma is the second most common liposarcoma. EWSR1-DDIT3 is a chimeric fusion protein generated by the myxoid liposarcoma-specific chromosomal...

Authors: Suzuki K, Matsui Y, Higashimoto M, Kawaguchi Y, Seki S, Motomura H, Hori T, Yahara Y, Kanamori M,...

SST Peer Reviewed

Autocrine signaling is a key regulatory element during osteoclastogenesis

Osteoclasts are responsible for bone destruction in degenerative, inflammatory and metastatic bone disorders. Although osteoclastogenesis has been well-characterized in mouse models, many questions remain regarding the regulation of osteoclast...

Authors: Kopesky P1, Tiedemann K2, Alkekhia D1, Zechner C1, Millard B1, Schoeberl B1, Komarova SV3

Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation

SCOPE:: Vascular smooth muscle cell (VSMC) proliferation is involved in the pathogenesis of cardiovascular disease, making the identification of new counteracting agents and their mechanisms of action relevant. Ginger and its constituents have...

Authors: Liu R, Heiss EH, Sider N, Schinkovitz A, Gröblacher B, Guo D, Bucar F, Bauer R, Dirsch VM, Atanasov...

Mesenchymal Stem Cells Conditioned Media Suppress Inflammation Associated Over-proliferation of Pulmonary Artery Smooth Muscle Cells in a Rat Model of Pulmonary Hypertension

Inflammation associated over-proliferation of pulmonary artery smooth muscle cells (PASMCs) is considered to be involved in the pathogenesis of pulmonary hypertension (PH). Even though administration of mesenchymal stem cells conditioned media...

Authors: Liu JF, Han Z, Han ZC, HeZX

SST Peer Reviewed

Mesenchymal Stem Cells Suppress Can/nfat Expression in Pulmonary Artery of Rat with Pulmonary Hypertension

OBJECTIVE: Inflammation and over-proliferation of pulmonary artery smooth muscle cells (PASMCs) have been considered as the major pathological features of pulmonary hypertension (PH). Here we aimed to determine that mesenchymal stem cells (MSCs)...

Authors: Liu JF, Han Z, Wu M, Han ZC, He ZX

SST Peer Reviewed

Human Mesenchymal Stem Cells Display Reduced Expression of CD105 after Culture in Serum-Free Medium.

Human Mesenchymal Stem Cells (hMSCs) present a promising tool for regenerative medicine. However, ex vivo expansion is necessary to obtain sufficient cells for clinical therapy. Conventional growth media usually contain the critical component fetal...

Authors: Mark P, Kleinsorge M, Gaebel R, Lux CA, Toelk A, Pittermann E, David R, Steinhoff G, Ma N

SST Peer Reviewed

Melanoma cells homing to the brain: an in vitro model

We developed an in vitro contact through-feet blood brain barrier (BBB) model built using type IV collagen, rat astrocytes, and human umbilical vein endothelial cells (HUVECs) cocultured through Transwell porous polycarbonate membrane. The contact...

Authors: Rizzo A, Vasco C, Girgenti V, Fugnanesi V, Calatozzolo C2, Canazza A, Salmaggi A, Rivoltini L,...

miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

Bone-resorbing osteoclasts significantly contribute to osteoporosis and bone metastases of cancer. MicroRNAs play important roles in physiology and disease, and present tremendous therapeutic potential. Nonetheless, how microRNAs regulate skeletal...

Authors: Krzeszinski JY1, Wei W1, Huynh H1, Jin Z1, Wang X1, Chang TC2, Xie XJ3, He L4, Mangala LS5,...

Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant

Generation of functional and vascularized organs from human induced pluripotent stem cells (iPSCs) will facilitate our understanding of human developmental biology and disease modeling, hopefully offering a drug-screening platform and providing novel...

Authors: Takebe T, Zhang RR, Koike H, Kimura M, Yoshizawa E, Enomura M, Koike N, Sekine K3, Taniguchi H.

Whole-genome sequence-based analysis of high-density lipoprotein cholesterol

We describe initial steps for interrogating whole-genome sequence data to characterize the genetic architecture of a complex trait, levels of high-density lipoprotein cholesterol (HDL-C). We report whole-genome sequencing and analysis of 962...

Authors: Morrison AC, Voorman A, Johnson AD, Liu X, Yu J, Li A, Muzny D, Yu F, Rice K, Zhu C, Bis J, Heiss G,...

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Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells

Autocrine signaling is a key regulatory element during osteoclastogenesis

Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation

Mesenchymal Stem Cells Conditioned Media Suppress Inflammation Associated Over-proliferation of Pulmonary Artery Smooth Muscle Cells in a Rat Model of Pulmonary Hypertension

Mesenchymal Stem Cells Suppress Can/nfat Expression in Pulmonary Artery of Rat with Pulmonary Hypertension

Human Mesenchymal Stem Cells Display Reduced Expression of CD105 after Culture in Serum-Free Medium.

Melanoma cells homing to the brain: an in vitro model

miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant

Whole-genome sequence-based analysis of high-density lipoprotein cholesterol