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Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

The CRISPR/Cas9 system is a robust genome editing technology that works in human cells, animals and plants based on the RNA-programmed DNA cleaving activity of the Cas9 enzyme. Building on previous work (Jinek et al., 2013), we show here that new...

Authors: Lin S, Staahl BT, Alla RK, Doudna JA.

Molecular subtyping of metastatic melanoma based on cell ganglioside metabolism profiles

BACKGROUND: In addition to alterations concerning the expression of oncogenes and onco-suppressors, melanoma is characterized by the presence of distinctive gangliosides (sialic acid carrying glycosphingolipids). Gangliosides strongly control cell...

Authors: Tringali C, Silvestri I, Testa F, Baldassari P, Anastasia L, Mortarini R, Anichini A, López-Requena...

Thyroid hormone receptor sumoylation is required for preadipocyte differentiation and proliferation.

Thyroid hormone and thyroid hormone receptor (TR) play an essential role in metabolic regulation. However, the role of TR in adipogenesis has not been established. We reported previously that TR sumoylation is essential for TR-mediated gene...

Authors: Liu YY, Ayers S, Milanesi A, Teng X, Rabi S, Akiba Y, Brent GA

SST Peer Reviewed

Rhesus macaque inhibitory and activating KIR3D interact with Mamu-A-encoded ligands.

Specific interactions between killer cell Ig-like receptors (KIRs) and MHC class I ligands have not been described in rhesus macaques despite their importance in biomedical research. Using KIR-Fc fusion proteins, we detected specific interactions for...

Authors: Rosner C1, Kruse PH, Hermes M, Otto N, Walter L.

S32212, a novel serotonin type 2C receptor inverse agonist/a2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization.

Although most antidepressants suppress serotonin (5-HT) and/or noradrenaline reuptake, blockade of 5-HT(2C) receptors and a(2)-adrenoceptors likewise enhances monoaminergic transmission. These sites are targeted by the urea derivative N-...

Authors: Millan MJ1, Mannoury la Cour C, Chanrion B, Dupuis DS, Di Cara B, Audinot V, Cussac D,...

Apolipoprotein A-I truncations in Chagas disease are caused by cruzipain, the major cysteine protease of Trypanosoma cruzi

Trypanosoma cruzi is the etiologic agent of Chagas disease. Approximately 10 million people are infected worldwide. We have previously reported that in individuals infected with T. cruzi, apolipoprotein A-I (Apo A-I), the major structural component...

Authors: Miao Q, Santamaria C, Bailey D, Genest J, Ward BJ, Ndao M

SST Peer Reviewed

Possible Mechanism of Low Endotoxin Recovery

Authors: M.Tsuchiya

Carbon nanotube fibers are compatible with Mammalian cells and neurons.

We demonstrate the biocompatibility of carbon nanotube fibers (CNFs) fabricated from single-wall carbon nanotubes. Produced by a particle-coagulation spinning process, CNFs are "hair-like" conductive microwires, which uniquely combine properties of...

Authors: Dubin RA, Callegari G, Kohn J, Neimark A.

Chronic superantigen exposure induces systemic inflammation, elevated bloodstream endotoxin, and abnormal glucose tolerance in rabbits: possible role in diabetes.

Excessive weight and obesity are associated with the development of diabetes mellitus type 2 (DMII) in humans. They also pose high risks of Staphylococcus aureus colonization and overt infections. S. aureus causes a wide range of severe illnesses in...

Authors: Vu BG, Stach CS, Kulhankova K, Salgado-Pabón W, Klingelhutz AJ, Schlievert PM

SST Peer Reviewed

Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile.

Sialoadhesin (Sn) is a sialic acid-binding Ig-like lectin expressed selectively on macrophage subsets. In a model of experimental autoimmune encephalomyelitis, Sn interacted with sialylated ligands expressed selectively on CD4(+)Foxp3(+) regulatory T...

Authors: Kidder D1, Richards HE, Ziltener HJ, Garden OA, Crocker PR.

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Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

Molecular subtyping of metastatic melanoma based on cell ganglioside metabolism profiles

Thyroid hormone receptor sumoylation is required for preadipocyte differentiation and proliferation.

Rhesus macaque inhibitory and activating KIR3D interact with Mamu-A-encoded ligands.

S32212, a novel serotonin type 2C receptor inverse agonist/a2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization.

Apolipoprotein A-I truncations in Chagas disease are caused by cruzipain, the major cysteine protease of Trypanosoma cruzi

Possible Mechanism of Low Endotoxin Recovery

Carbon nanotube fibers are compatible with Mammalian cells and neurons.

Chronic superantigen exposure induces systemic inflammation, elevated bloodstream endotoxin, and abnormal glucose tolerance in rabbits: possible role in diabetes.

Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile.