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A mixed mirror-image DNA/RNA aptamer inhibits glucagon and acutely improves glucose tolerance in models of type 1 and type 2 diabetes.

Excessive secretion of glucagon, a functional insulin antagonist, significantly contributes to hyperglycemia in type 1 and type 2 diabetes. Accordingly, immunoneutralization of glucagon or genetic deletion of the glucagon receptor improved glucose...
Authors: Vater A1, Sell S, Kaczmarek P, Maasch C, Buchner K, Pruszynska-Oszmalek E, Kolodziejski P, Purschke...

Simple and rapid molecular techniques for identification of amylose levels in rice varieties

The polymorphisms of Waxy (Wx) microsatellite and G-T single-nucleotide polymorphism (SNP) in the Wx gene region were analyzed using simplified techniques in fifteen rice varieties. A rapid and reliable electrophoresis method, MetaPhor agarose gel...
Authors: Cheng A, Ismail I, Osman M, Hashim H.

Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness.

Through a rational design approach, we generated a panel of HLA-A*0201/NY-ESO-1(157-165)-specific T cell receptors (TCR) with increasing affinities of up to 150-fold from the wild-type TCR. Using these TCR variants which extend just beyond the...
Authors: Irving M1, Zoete V, Hebeisen M, Schmid D, Baumgartner P, Guillaume P, Romero P, Speiser D, Luescher...

T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice.

T lymphocytes are key contributors to the acute phase of cerebral ischemia reperfusion injury, but the relevant T cell-derived mediators of tissue injury remain unknown. Using a mouse model of transient focal brain ischemia, we report that IL-21 is...
Authors: Clarkson BD1, Ling C, Shi Y, Harris MG, Rayasam A, Sun D, Salamat MS, Kuchroo V, Lambris JD, Sandor...

Efficient expression of acetylcholine-binding protein from Aplysia californica in Bac-to-Bac system.

The Bac-to-Bac baculovirus expression system can efficiently produce recombinant proteins, but the system may have to be optimized to achieve high-level expression for different candidate proteins. We reported here the efficient expression of...
Authors: Lin B1, Meng H1, Bing H1, Zhangsun D1, Luo S1.
SST Peer Reviewed

Role of phospholipase D2/phosphatidic acid signal transduction in micro- and delta-opioid receptor endocytosis.

We demonstrated recently that opioid-induced activation of phospholipase D2 (PLD2) enhances mu- (MOPr) and delta-opioid receptor endocytosis/recycling and thus reduces the development of opioid receptor desensitization and tolerance. However, the...
Authors: Yang L1, Seifert A, Wu D, Wang X, Rankovic V, Schröder H, Brandenburg LO, Höllt V, Koch T.

A novel method using blinatumomab for efficient, clinical-grade expansion of polyclonal T cells for adoptive immunotherapy.

Current treatment of chronic lymphocytic leukemia (CLL) patients often results in life-threatening immunosuppression. Furthermore, CLL is still an incurable disease due to the persistence of residual leukemic cells. These patients may therefore...
Authors: Golay J, D'Amico A, Borleri G, Bonzi M, Valgardsdottir R, Alzani R, Cribioli S, Albanese C, Pesenti...
SST Peer Reviewed

Multilocus microsatellite signature and identification of specific molecular markers for Leishmania aethiopica

BACKGROUND: Leishmaniasis is a clinically and epidemiologically diverse zoonotic disease caused by obligatory, intracellular protozoan parasites of the genus Leishmania. Cutaneous leishmaniasis is the most widely distributed form of the disease...
Authors: Kebede N, Oghumu S, Worku A, Hailu A, Varikuti S, Satoskar AR.

Diploid chromosome number and chromosomal variation in the white rhinoceros (Ceratotherium simum).

Chromosomal studies were conducted on 38 white rhinoceroses representing both the northern and southern subspecies and one subspecies hybrid. Improvements in tissue culture methods and harvesting techniques have made it possible to obtain a highly...
Authors: Houck ML, Ryder OA, Váhala J, Kock RA, Oosterhuis JE

Calsyntenin-3 molecular architecture and interaction with neurexin 1a.

Calsyntenin 3 (Cstn3 or Clstn3), a recently identified synaptic organizer, promotes the development of synapses. Cstn3 localizes to the postsynaptic membrane and triggers presynaptic differentiation. Calsyntenin members play an evolutionarily...
Authors: Lu Z, Wang Y, Chen F, Tong H, Reddy MV, Luo L, Seshadrinathan S, Zhang L, Holthauzen LM, Craig AM,...
SST Peer Reviewed
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