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Protein kinase Darkener of apricot and its substrate EF1gamma regulate organelle transport along microtubules.

Regulation of organelle transport along microtubules is important for proper distribution of membrane organelles and protein complexes in the cytoplasm. RNAi-mediated knockdown in cultured Drosophila S2 cells demonstrates that two microtubule-binding...

Authors: Serpinskaya AS1, Tuphile K, Rabinow L, Gelfand VI.

Rhesus macaque inhibitory and activating KIR3D interact with Mamu-A-encoded ligands.

Specific interactions between killer cell Ig-like receptors (KIRs) and MHC class I ligands have not been described in rhesus macaques despite their importance in biomedical research. Using KIR-Fc fusion proteins, we detected specific interactions for...

Authors: Rosner C1, Kruse PH, Hermes M, Otto N, Walter L.

XaxAB-like binary toxin from Photorhabdus luminescens exhibits both insecticidal activity and cytotoxicity.

The enterobacterium Photorhabdus luminescens produces a number of toxins to kill its insect host. By analyzing the genomic sequence of P. luminescens TT01, we found that amino acid sequences encoded by plu1961 and plu1962 showed high similarity to...

Authors: Zhang X1, Hu X, Li Y, Ding X, Yang Q, Sun Y, Yu Z, Xia L, Hu S.

SLAT/Def6 plays a critical role in the pathogenic process of experimental autoimmune uveitis (EAU).

PURPOSE: SWAP 70-like adaptor of T cells (SLAT; aka Def6) is a recently discovered guanine nucleotide exchange factor for Rho guanosine triphosphate (GTP)ases that has been previously shown to play a role in cluster of differentiation(CD)4+ T...

Authors: Vistica BP, Shi G, Nugent L, Tan C, Altman A, Gery I.

S32212, a novel serotonin type 2C receptor inverse agonist/a2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization.

Although most antidepressants suppress serotonin (5-HT) and/or noradrenaline reuptake, blockade of 5-HT(2C) receptors and a(2)-adrenoceptors likewise enhances monoaminergic transmission. These sites are targeted by the urea derivative N-...

Authors: Millan MJ1, Mannoury la Cour C, Chanrion B, Dupuis DS, Di Cara B, Audinot V, Cussac D,...

Biochemical and biological studies of mouse APOBEC3.

Many murine leukemia viruses (MLVs) are partially resistant to restriction by mouse APOBEC3 (mA3) and essentially fully resistant to induction of G-to-A mutations by mA3. In contrast, Vif-deficient HIV-1 (?Vif HIV-1) is profoundly restricted by mA3,...

Authors: Nair S1, Sanchez-Martinez S, Ji X, Rein A.

Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile.

Sialoadhesin (Sn) is a sialic acid-binding Ig-like lectin expressed selectively on macrophage subsets. In a model of experimental autoimmune encephalomyelitis, Sn interacted with sialylated ligands expressed selectively on CD4(+)Foxp3(+) regulatory T...

Authors: Kidder D1, Richards HE, Ziltener HJ, Garden OA, Crocker PR.

Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers.

During M phase, Endosulfine (Endos) family proteins are phosphorylated by Greatwall kinase (Gwl), and the resultant pEndos inhibits the phosphatase PP2A-B55, which would otherwise prematurely reverse many CDK-driven phosphorylations. We show here...

Authors: Williams BC1, Filter JJ, Blake-Hodek KA, Wadzinski BE, Fuda NJ, Shalloway D, Goldberg ML.

Changes in culture expanded human amniotic epithelial cells: implications for potential therapeutic applications.

Human amniotic epithelial cells (hAEC) isolated from term placenta have stem cell-like properties, differentiate into tissue specific cells and reduce lung and liver inflammation and fibrosis following transplantation into disease models established...

Authors: Pratama G, Vaghjiani V, Tee JY, Liu YH, Chan J, Tan C, Murthi P, Gargett C, Manuelpillai U.

Photorhabdus luminescens PirAB-fusion protein exhibits both cytotoxicity and insecticidal activity.

The binary toxin 'Photorhabdus insect-related' proteins (PirAB) produced by Photorhabdus luminescens have been reported to possess both injectable and oral activities against a range of insects. Here, PirAB-fusion protein was constructed by linking...

Authors: Li Y1, Hu X, Zhang X, Liu Z, Ding X, Xia L, Hu S.

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