Search Results

The myeloid transcription factor GATA-2 regulates the viral UL144 gene during human cytomegalovirus latency in an isolate-specific manner.

It is generally accepted that, following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency in CD34(+) progenitor cells and other derivative cells of the myeloid lineage. In this study, we show that the viral UL144 gene is...

Authors: Poole E, Walther A, Raven K, Benedict CA, Mason GM, Sinclair J.

SST Peer Reviewed

Growth of engineered human myocardium with mechanical loading and vascular coculture.

RATIONALE: The developing heart requires both mechanical load and vascularization to reach its proper size, yet the regulation of human heart growth by these processes is poorly understood. OBJECTIVE: We seek to elucidate the responses of immature...

Authors: Tulloch NL, Muskheli V, Razumova MV, Korte FS, Regnier M, Hauch KD, Pabon L, Reinecke H, Murry CE.

SST Peer Reviewed

Early host responses of seasonal and pandemic influenza A viruses in primary well-differentiated human lung epithelial cells

Replication, cell tropism and the magnitude of the host's antiviral immune response each contribute to the resulting pathogenicity of influenza A viruses (IAV) in humans. In contrast to seasonal IAV in human cases, the 2009 H1N1 pandemic IAV...

Authors: Gerlach RL, Camp JV, Chu YK, Jonsson CB

Isoelectric focusing in agarose gel for detection of oligoclonal bands in cerebrospinal and other biological fluids

Isoelectric focusing (IEF) coupled with immunodetection (immunofixation or immunoblotting) has become the leading technique for the detection and study of oligoclonal bands (OCBs) in cerebrospinal fluid (CSF) and also is increasingly used in other...

Authors: Csako G.

Enhanced angiogenesis and increased cardiac perfusion after myocardial infarction in protein tyrosine phosphatase 1B-deficient mice.

The protein tyrosine phosphatase 1B (PTP1B) modulates tyrosine kinase receptors, among which is the vascular endothelial growth factor receptor type 2 (VEGFR2), a key component of angiogenesis. Because PTP1B deficiency in mice improves left...

Authors: Besnier M, Galaup A, Nicol L, Henry JP, Coquerel D, Gueret A, Mulder P, Brakenhielm E, Thuillez C,...

SST Peer Reviewed

Relevant shaking stress conditions for antibody preformulation development.

In protein formulation development, shaking stress is often employed to assess the physical stability of antibody formulations against aggregation. Since there are currently no guidelines describing suitable test conditions, very different shaking...

Authors: Eppler A, Weigandt M, Hanefeld A, Bunjes H.

Extending human hematopoietic stem cell survival in vitro with adipocytes.

Human hematopoietic stem cells (hHSCs) cannot be maintained in vitro for extended time periods because they rapidly differentiate or die. To extend in vitro culture time, researchers have made attempts to use human mesenchymal stem cells (hMSCs) to...

Authors: Glettig DL, Kaplan DL.

SST Peer Reviewed

An innovative approach for the characterization of the isoforms of a monoclonal antibody product

Protein biopharmaceuticals, such as monoclonal antibodies (mAbs) are widely used for the prevention and treatment of various diseases. The complex and lengthy upstream and downstream production methods of the antibodies make them susceptible to...

Authors: Sundaram S1, Matathia A, Qian J, Zhang J, Hsieh MC, Liu T, Crowley R, Parekh B, Zhou Q.

Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling

The development of bispecific antibodies as therapeutic agents for human diseases has great clinical potential, but broad application has been hindered by the difficulty of identifying bispecific antibody formats that exhibit favorable...

Authors: Jackman J, Chen Y, Huang A, Moffat B, Scheer JM, Leong SR, Lee WP, Zhang J, Sharma N, Lu Y, Iyer S,...

Human umbilical cord blood progenitors: the potential of these hematopoietic cells to become neural.

The mononuclear fraction from human umbilical cord blood (HUCB) contains a significant number of stem/progenitor cells that in theory could be come any cell in the body, including neurons. Taking into consideration that transdifferentiation would be...

Authors: Chen N, Hudson JE, Walczak P, Misiuta I, Garbuzova-Davis S, Jiang L, Sanchez-Ramos J, Sanberg PR,...

SST Peer Reviewed

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The myeloid transcription factor GATA-2 regulates the viral UL144 gene during human cytomegalovirus latency in an isolate-specific manner.

Growth of engineered human myocardium with mechanical loading and vascular coculture.

Early host responses of seasonal and pandemic influenza A viruses in primary well-differentiated human lung epithelial cells

Isoelectric focusing in agarose gel for detection of oligoclonal bands in cerebrospinal and other biological fluids

Enhanced angiogenesis and increased cardiac perfusion after myocardial infarction in protein tyrosine phosphatase 1B-deficient mice.

Relevant shaking stress conditions for antibody preformulation development.

Extending human hematopoietic stem cell survival in vitro with adipocytes.

An innovative approach for the characterization of the isoforms of a monoclonal antibody product

Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling

Human umbilical cord blood progenitors: the potential of these hematopoietic cells to become neural.