Search Results

N-glycosylations of human a1,3-fucosyltransferase IX are required for full enzyme activity

Human a1,3-fucosyltransferase IX catalyzes the transfer of l-fucose from guanosine diphosphate-ß-L-fucose to N-acetyllactosamine, generating a Lewis X epitope, and is thereby involved in the synthesis of fucosylated cell surface glycoconjugates. It...

Authors: Seelhorst K1, Stacke C, Ziegelmüller P, Hahn U.

Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds.

Identification of appropriate donor cell types is important for lung cell therapy and for lung regeneration. Previous studies have indicated that mesenchymal stromal cells derived from human bone marrow (hBM-MSCs) and from human adipose tissue...

Authors: Mendez JJ, Ghaedi M, Steinbacher D, Niklason LE.

Myosin Vc interacts with Rab32 and Rab38 and works in the biogenesis and secretion of melanosomes

Class V myosins are actin-based motors with conserved functions in vesicle and organelle trafficking. Herein, we report the discovery of a function for Myosin Vc in melanosome biogenesis as an effector of melanosome-associated Rab GTPases. We...

Authors: Bultema JJ, Boyle JA, Malenke PB, Martin FE, Dell\\\'Angelica EC, Cheney RE, Di Pietro SM

In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound.

Widespread drug resistance calls for the urgent development of new antimalarials that target novel steps in the life cycle of Plasmodium falciparum and Plasmodium vivax. The essential subtilisin-like serine protease SUB1 of Plasmodium merozoites...

Authors: Bouillon A1, Giganti D, Benedet C, Gorgette O, Pêtres S, Crublet E, Girard-Blanc C, Witkowski B,...

Monocyte interaction accelerates HCl-induced lung epithelial remodeling.

BACKGROUND: Acute respiratory distress syndrome (ARDS) is characterized by overwhelming inflammatory responses and lung remodeling. We hypothesized that leukocyte infiltration during the inflammatory response modulates epithelial remodeling through...

Authors: Chen Q, Luo AA, Qiu H, Han B, Ko BH, Slutsky AS, Zhang H

Kaposi's Sarcoma-Associated Herpesvirus Subversion of the Anti-Inflammatory Response in Human Skin Cells Reveals Correlates of Latency and Disease Pathogenesis

KSHV is the etiologic agent for Kaposi's sarcoma (KS), a neoplasm that manifests most aggressively as multifocal lesions on parts of human skin with a propensity for inflammatory reactivity. However, mechanisms that control evolution of KS from a...

Authors: Fontana JM, Mygatt JG, Conant KL, Parsons CH, Kaleeba JA

Avian Influenza Virus Infection of Immortalized Human Respiratory Epithelial Cells Depends upon a Delicate Balance between Hemagglutinin Acid Stability and Endosomal pH.

The highly pathogenic avian influenza (AI) virus, H5N1, is a serious threat to public health worldwide. Both the currently-circulating H5N1 and previously-circulating AI viruses recognize avian-type receptors; however, only the H5N1 is highly...

Authors: Daidoji T, Watanabe Y, Ibrahim MS, Yasugi M, Maruyama H, Masuda T, Arai F, Ohba T, Honda A, Ikuta K,...

Mitochondrial protein BmPAPI modulates the length of mature piRNAs.

PIWI proteins and their associated PIWI-interacting RNAs (piRNAs) protect genome integrity by silencing transposons in animal germlines. The molecular mechanisms and components responsible for piRNA biogenesis remain elusive. PIWI proteins contain...

Authors: Honda S, Kirino Y, Maragkakis M, Alexiou P, Ohtaki A, Murali R, Mourelatos Z, Kirino Y.

Molecular subtyping of metastatic melanoma based on cell ganglioside metabolism profiles

BACKGROUND: In addition to alterations concerning the expression of oncogenes and onco-suppressors, melanoma is characterized by the presence of distinctive gangliosides (sialic acid carrying glycosphingolipids). Gangliosides strongly control cell...

Authors: Tringali C, Silvestri I, Testa F, Baldassari P, Anastasia L, Mortarini R, Anichini A, López-Requena...

Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells

The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is hyperactivated in a variety of cancers and disorders, including lymphangioleiomyomatosis (LAM) and tuberous sclerosis complex (TSC), which are characterized by...

Authors: Alayev A, Sun Y, Snyder RB, Berger SM, Yu JJ, Holz MK

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