Search Results

A matrix micropatterning platform for cell localization and stem cell fate determination.

To study the role of cell-extracellular matrix (ECM) interactions, microscale approaches provide the potential to perform high throughput assessment of the effect of the ECM microenvironment on cellular function and phenotype. Using a microscale...

Authors: Huang NF, Patlolla B, Abilez O, Sharma H, Rajadas J, Beygui RE, Zarins CK, Cooke JP

Cardiotoxicity of the anticancer therapeutic agent bortezomib

Recent case reports provided alarming signals that treatment with bortezomib might be associated with cardiac events. In all reported cases, patients experiencing cardiac problems were previously or concomitantly treated with other chemotherapeutics...

Authors: Nowis D, Maczewski M, Mackiewicz U, Kujawa M, Ratajska A, Wieckowski MR, Wilczynski GM, Malinowska...

Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology

Development and regeneration of the nervous system requires the precise formation of axons and dendrites. Kinases and phosphatases are pervasive regulators of cellular function and have been implicated in controlling axodendritic development and...

Authors: Buchser WJ, Slepak TI, Gutierrez-Arenas O, Bixby JL, Lemmon VP

SST Peer Reviewed

Isolation of mouse mesenchymal stem cells on the basis of expression of Sca-1 and PDGFR-a.

Platelet-derived growth factor receptor a (PDGFR-a) and stem cell antigen 1 (Sca-1) have recently been identified as selective markers of mouse mesenchymal stem cells (MSCs). PDGFR-a(+)Sca-1(+) (PaS) MSCs have augmented growth potential and robust...

Authors: Houlihan DD, Mabuchi Y, Morikawa S, Niibe K, Araki D, Suzuki S, Okano H, Matsuzaki Y.

SST Peer Reviewed

Epithelial-derived TGF-beta2 modulates basal and wound-healing subepithelial matrix homeostasis.

The epithelium influences the mesenchyme during dynamic processes such as embryogenesis, wound healing, fibrosis, and carcinogenesis. Since transforming growth factor-beta (TGF-beta) modulates these processes, we hypothesized that epithelial-derived...

Authors: Thompson HG, Mih JD, Krasieva TB, Tromberg BJ, George SC.

Molecular analysis of chondrocytes cultured in agarose in response to dynamic compression.

BACKGROUND: Articular cartilage is exposed to high mechanical loads under normal physiological conditions and articular chondrocytes regulate the composition of cartilaginous matrix, in response to mechanical signals. However, the intracellular...

Authors: Bougault C, Paumier A, Aubert-Foucher E, Mallein-Gerin F.

CD56 expression in human myeloma cells derived from the neurogenic gene expression: possible role of the SRY-HMG box gene, SOX4.

CD56 is frequently detected on primary myeloma cells from more than 80% patients with overt myeloma. In order to clarify the possible mechanisms of CD56 expression in human myeloma, we underwent screening for potential targets by microarray analysis,...

Authors: Iqbal MS, Otsuyama K, Shamsasenjan K, Asaoku H, Kawano MM.

Hyperactive piggyBac Gene Transfer in Human Cells and In Vivo

We characterized a recently developed hyperactive piggyBac (pB) transposase enzyme [containing seven mutations (7pB)] for gene transfer in human cells in vitro and to somatic cells in mice in vivo. Despite a protein level expression similar to that...

Authors: Joseph E. Doherty,Leslie E. Huye, Kosuke Yusa, Liqin Zhou, Nancy L. Craig, Matthew H. Wilson

Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury.

Endogenous agonists of transient receptor potential vanilloid-1 (TRPV1) (endovanilloids) are implicated as mediators of lung injury during inflammation. This study tested the hypothesis that endovanilloids produced following lipopolysaccharide (LPS)...

Authors: Thomas KC, Roberts JK, Deering-Rice CE, Romero EG, Dull RO, Lee J, Yost GS, Reilly CA.

High-efficiency transfection and survival rates of embryonic and adult mouse neural stem cells achieved by electroporation

Cells of the central nervous system are notoriously difficult to transfect. This is not only true for neurons and glial cells but also for dividing neural stem and progenitor cells (NSCs). About ten years ago a major advance was provided by...

Authors: Bettina Bertrama, Stefan Wiesea, Alexander von Holst

SST Peer Reviewed

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A matrix micropatterning platform for cell localization and stem cell fate determination.

Cardiotoxicity of the anticancer therapeutic agent bortezomib

Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology

Isolation of mouse mesenchymal stem cells on the basis of expression of Sca-1 and PDGFR-a.

Epithelial-derived TGF-beta2 modulates basal and wound-healing subepithelial matrix homeostasis.

Molecular analysis of chondrocytes cultured in agarose in response to dynamic compression.

CD56 expression in human myeloma cells derived from the neurogenic gene expression: possible role of the SRY-HMG box gene, SOX4.

Hyperactive piggyBac Gene Transfer in Human Cells and In Vivo

Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury.

High-efficiency transfection and survival rates of embryonic and adult mouse neural stem cells achieved by electroporation