Search Results

Cell density impacts epigenetic regulation of cytokine-induced E-selectin gene expression in vascular endothelium

Growing evidence suggests that the phenotype of endothelial cells during angiogenesis differs from that of quiescent endothelial cells, although little is known regarding the difference in the susceptibility to inflammation between both the...

Authors: Hamada K, Osaka M, Yoshida M

Design and evaluation of locked nucleic acid-based splice-switching oligonucleotides in vitro.

Antisense-mediated modulation of pre-mRNA splicing is an attractive therapeutic strategy for genetic diseases. Currently, there are few examples of modulation of pre-mRNA splicing using locked nucleic acid (LNA) antisense oligonucleotides, and, in...

Authors: Shimo T1, Tachibana K1, Saito K1, Yoshida T2, Tomita E3, Waki R1, Yamamoto T1, Doi T1, Inoue T2,...

Immune mediators regulate CFTR expression through a bifunctional airway-selective enhancer

An airway-selective DNase-hypersensitive site (DHS) at kb -35 (DHS-35kb) 5' to the cystic fibrosis transmembrane conductance regulator (CFTR) gene is evident in many lung cell lines and primary human tracheal epithelial cells but is absent from...

Authors: Zhang Z, Leir SH, Harris A

LAT1 is a central transporter of essential amino acids in human umbilical vein endothelial cells

Endothelial cell proliferation supporting angiogenesis requires sufficient nutrient supply because of facilitated intracellular metabolism. However, little is known about the mechanism for the promotion of nutrient incorporation in proliferating...

Authors: Hayashi K, Jutabha P, Kamai T, Endou H, Anzai N

Characterization of primary human skeletal muscle cells from multiple commercial sources.

There is a significant unmet need for safe, anabolic muscle therapies to treat diseases and conditions associated with severe muscle weakness and frailty. The identification of such therapies requires appropriate cell-based screening assays to select...

Authors: Owens J1, Moreira K, Bain G.

Flt3-mediated signaling in human acute myelogenous leukemia (AML) blasts: a functional characterization of Flt3-ligand effects in AML cell populations with and without genetic Flt3 abnormalities.

BACKGROUND AND OBJECTIVES: Intracellular signaling initiated via Flt3 seems important in both leukemogenesis and chemosensitivity in acute myelogenous leukemia (AML). Flt3 is activated by binding of its natural Flt3-ligand (Flt3-L), but Flt3...

Authors: Bruserud Ø, Hovland R, Wergeland L, Huang TS, Gjertsen BT.

SST Peer Reviewed

Evaluation of a whole-blood cytokine release assay for use in measuring endotoxin activity of group B Neisseria meningitidis vaccines made from lipid A acylation mutants.

Bacterial endotoxin interacts with the human immune system via complex immunological pathways. The evaluation of endotoxicity is important in the development of safe vaccines and immunomodulatory therapeutics. The Limulus amebocyte lysate (LAL) assay...

Authors: Stoddard MB, Pinto V, Keiser PB, Zollinger W.

SST Peer Reviewed

Therapeutic targeting of tumor growth and angiogenesis with a novel anti-S100A4 monoclonal antibody

S100A4, a member of the S100 calcium-binding protein family secreted by tumor and stromal cells, supports tumorigenesis by stimulating angiogenesis. We demonstrated that S100A4 synergizes with vascular endothelial growth factor (VEGF), via the RAGE...

Authors: Hernández JL, Padilla L, Dakhel S, Coll T, Hervas R, Adan J, Masa M, Mitjans F, Martinez JM, Coma S,...

Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium

Influenza viruses do not encode any proteases and must rely on host proteases for the proteolytic activation of their surface hemagglutinin proteins in order to fuse with the infected host cells. Recent progress in the understanding of human...

Authors: Beaulieu A, Gravel É, Cloutier A, Marois I, Colombo É, Désilets A, Verreault C, Leduc R, Marsault É,...

Gremlin-2 is a BMP antagonist that is regulated by the circadian clock.

Tendons are prominent members of the family of fibrous connective tissues (FCTs), which collectively are the most abundant tissues in vertebrates and have crucial roles in transmitting mechanical force and linking organs. Tendon diseases are among...

Authors: Yeung CY1, Gossan N1, Lu Y1, Hughes A2, Hensman JJ3, Bayer ML4, Kjær M4, Kadler KE1, Meng QJ1

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