Search Results

Neuropilin-2 promotes extravasation and metastasis by interacting with endothelial a5 integrin

Metastasis, the leading cause of cancer death, requires tumor cell intravasation, migration through the bloodstream, arrest within capillaries, and extravasation to invade distant tissues. Few mechanistic details have been reported thus far regarding...

Authors: Cao Y, Hoeppner LH, Bach S, E G, Guo Y, Wang E, Wu J, Cowley MJ, Chang DK, Waddell N, Grimmond SM,...

STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma

PURPOSE: Signal transducer and activator of transcription 3 (STAT3) has shown to play a critical role in head and neck squamous cell carcinoma (HNSCC) and we have recently completed clinical trials of STAT3 decoy oligonucleotide in patients with...

Authors: Klein JD, Sano D, Sen M, Myers JN, Grandis JR, Kim S

Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits ß-catenin degradation

Ablation of tetraspanin protein TSPAN12 from human MDA-MB-231 cells significantly decreased primary tumor xenograft growth, while increasing tumor apoptosis. Furthermore, TSPAN12 removal markedly enhanced tumor-endothelial interactions and increased...

Authors: Knoblich K, Wang HX, Sharma C, Fletcher AL, Turley SJ, Hemler ME

Arkadia regulates tumor metastasis by modulation of the TGF-ß pathway

TGF-ß can act as a tumor suppressor at early stages of cancer progression and as a tumor promoter at later stages. The E3 ubiquitin ligase Arkadia (RNF111) is a critical component of the TGF-ß signaling pathway, being required for a subset of...

Authors: Briones-Orta MA, Levy L, Madsen CD, Das D, Erker Y, Sahai E, Hill CS

Growth and structural discrimination of cortical neurons on randomly oriented and vertically aligned dense carbon nanotube networks.

The growth of cortical neurons on three dimensional structures of spatially defined (structured) randomly oriented, as well as on vertically aligned, carbon nanotubes (CNT) is studied. Cortical neurons are attracted towards both types of CNT...

Authors: Nick C, Yadav S, Joshi R, Thielemann C, Schneider JJ.

SST Peer Reviewed

Discovering aptamers by cell-SELEX against human soluble growth factors ectopically expressed on yeast cell surface

SELEX, the process of selecting aptamers, is often hampered by the difficulty of preparing target molecules in their native forms and by a lack of a simple yet quantitative assay for monitoring enrichment and affinity of reactive aptamers. In this...

Authors: Meng HW, Pagano JM, White BS, Toyoda Y, Min IM, Craighead HG, Shalloway D, Lis JT, Xiao K, Jin MM

Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis

The release of humoral factors between cancer cells and the microenvironmental cells is critical for metastasis; however, the roles of secreted miRNAs in non-cell autonomous cancer progression against microenvironmental cells remain largely unknown....

Authors: Kosaka N, Iguchi H, Hagiwara K, Yoshioka Y, Takeshita F, Ochiya T

Altered hMSC functional characteristics in short-term culture and when placed in low oxygen environments: implications for cell retention at physiologic sites

BACKGROUND: It is very difficult to conserve critical cell characteristics during expansion in culture, particularly those of adult mesenchymal stromal cells (MSCs), whose characteristics can change rapidly even within a short period of expansion....

Authors: Bain O, Detela G, Kim HW, Mason C, Mathur A, Wall IB

The small GTPase RhoB regulates TNFa signaling in endothelial cells

The inflammatory response of endothelial cells triggered by cytokines such as TNFa and IL1ß plays a pivotal role in innate immunity. Upon pro-inflammatory cytokine stimulation, endothelial cells produce chemokines and cytokines that attract and...

Authors: Kroon J, Tol S, van Amstel S, Elias JA, Fernandez-Borja M

FXYD5 (dysadherin) regulates the paracellular permeability in cultured kidney collecting duct cells.

FXYD5 (dysadherin or RIC) is a member of the FXYD family of single-span transmembrane proteins associated with the Na(+)-K(+)-ATPase. Several studies have demonstrated enhanced expression of FXYD5 during metastasis and effects on cell adhesion and...

Authors: Lubarski I1, Asher C, Garty H.

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