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Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells.

Invariant NKT (iNKT) cells are a subset of T lymphocytes that recognize glycolipid Ags presented by the MHC class I-related protein CD1d. Activation of iNKT cells with glycolipid Ags, such as the marine sponge-derived reagent a-galactosylceramide...

Authors: Parekh VV1, Wu L, Olivares-Villagómez D, Wilson KT, Van Kaer L.

A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts.

Fetal hemoglobin (HbF) is a potent genetic modifier of the severity of beta-thalassemia and sickle cell anemia. We used an in vitro culture model of human erythropoiesis in which late-stage erythroblasts are derived directly from human CD34(+)...

Authors: Wilber A, Tschulena U, Hargrove PW, Kim YS, Persons DA, Barbas CF 3rd, Nienhuis AW.

SST Peer Reviewed

Construction of a Three-Dimensional Human Skin Model Consisting of Keratinocytes, Dendritic Cells and Fibroblasts and Application of This Model for Alternative Animal Testing of Immune-Sensitizing Compounds

In order to establish in vitro evaluation of the sensitization of human skin, we attempted to make a three-dimensional human skin model consisting of three different cells, dendritic cells, keratinocytes and fibroblasts. The viability of the cells in...

Authors: Uchino T, Ikarashi Y, Tokunaga H

SST Peer Reviewed

Sphingoid bases induce dose-dependent cytotoxicity and cytokine responses in human myeloid dendritic cells

Sphingoid bases (sphingosine, dihydrosphingosine and phytosphingosine) have been recently found in the oral cavity where they may serve to fortify innate immunity against commensals and periodontal pathogens. In fact, sphingoid bases have potent...

Authors: Mehalick LA

SST Peer Reviewed

Characterization of adipose-derived mesenchymal stem cell combinations for vascularized bone engineering

Since bone repair and regeneration depend on vasculogenesis and osteogenesis, both of these processes are essential for successful vascularized bone engineering. Using adipose-derived stem cells (ASCs), we investigated temporal gene expression...

Authors: Valenzuela CD, Allori AC, Reformat DD, Sailon AM, Allen RJ Jr, Davidson EH, Alikhani M, Bromage TG,...

In vivo and in vitro characterization of the angiogenic effect of CTX0E03 human neural stem cells

CTX0E03 is a human neural stem cell line previously reported to reduce sensory motor deficits in a middle cerebral artery occlusion (MCAo) model of stroke. The objective of this study was to investigate if CTX0E03 treatment promotes angiogenesis. As...

Authors: Hicks C, Stevanato L, Stroemer RP, Tang E, Richardson S, Sinden JD

Expression and differentiation between OCT4A and its Pseudogenes in human ESCs and differentiated adult somatic cells

The POU5F1 gene codes for the OCT4 transcription factor, which is one of the key regulators of pluripotency. Its transcription, alternative splicing, and alternative translation leading to the synthesis of the active, nuclear localized OCT4A has been...

Authors: Jez M, Ambady S, Kashpur O, Grella A, Malcuit C, Vilner L, Rozman P, Dominko T

TEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function

Signaling events mediated by Rho family GTPases orchestrate cytoskeletal dynamics and cell junction formation. The activation of Rho GTPases is tightly regulated by guanine-nucleotide-exchange factors (GEFs). In this study, we identified a novel...

Authors: Ngok SP, Geyer R, Kourtidis A, Mitin N, Feathers R, Der C, Anastasiadis PZ

Ephrin-A1 is up-regulated by hypoxia in cancer cells and promotes angiogenesis of HUVECs through a coordinated cross-talk with eNOS

Hypoxia, ephrin-A1 and endothelial nitric oxide synthase (eNOS) have been proved to play critical roles in tumor angiogenesis. However, how ephrin-A1 is regulated by hypoxia and whether ephrin-A1 cooperates with eNOS in modulation of angiogenesis...

Authors: Song Y, Zhao XP, Song K, Shang ZJ

Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells

Mesenchymal stem cells natively circulating or delivered into the blood stream home to sites of injury. The mechanism of mesenchymal stem cell homing to sites of injury is poorly understood. We have shown that the development of apoptosis in...

Authors: Potapova IA, Cohen IS, Doronin SV

SST Peer Reviewed

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Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells.

A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts.

Construction of a Three-Dimensional Human Skin Model Consisting of Keratinocytes, Dendritic Cells and Fibroblasts and Application of This Model for Alternative Animal Testing of Immune-Sensitizing Compounds

Sphingoid bases induce dose-dependent cytotoxicity and cytokine responses in human myeloid dendritic cells

Characterization of adipose-derived mesenchymal stem cell combinations for vascularized bone engineering

In vivo and in vitro characterization of the angiogenic effect of CTX0E03 human neural stem cells

Expression and differentiation between OCT4A and its Pseudogenes in human ESCs and differentiated adult somatic cells

TEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function

Ephrin-A1 is up-regulated by hypoxia in cancer cells and promotes angiogenesis of HUVECs through a coordinated cross-talk with eNOS

Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells