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MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase

MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Teng G, Hakimpour P, Landgraf P, Rice A, Tuschl T, Casellas R, Papavasiliou FN. Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New...

Authors: Teng G, Hakimpour P, Landgraf P, Rice A, Tuschl T, Casellas R, Papavasiliou FN

FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase

In T cells, the PI3K pathway promotes proliferation and survival induced by Ag or growth factors, in part by inactivating the FOXO transcription factor 1. We now report that FOXO1 controls the expression of L-selectin, an essential homing molecule,...

Authors: Fabre S, Carrette F, Chen J, Lang V, Semichon M, Denoyelle C, Lazar V, Cagnard N,...

Dramatic caspase-dependent apoptosis in antibody-enhanced dengue virus infection of human mast cells

Severe forms of dengue virus disease, known as dengue hemorrhagic fever and dengue shock syndrome, result from an aberrant immune response involving antibody-dependent enhancement of infection, thrombocytopenia, and a loss of vascular integrity,...

Authors: Brown MG, Huang YY, Marshall JS, King CA, Hoskin DW, Anderson R

Selective Partial Agonism of Liver X Receptor alpha Is Related to Differential Corepressor Recruitment

Classically, activated transcription by nuclear receptors (NRs) is due to a ligand-induced switch from corepressor to coactivator bound states. However, coactivators and corepressors recognize overlapping surfaces of liganded and unliganded NRs,...

Authors: Phelan CA, Weaver JM, Steger DJ, Joshi S, Maslany JT, Collins JL, Zuercher WJ, Willson TM, Walker M,...

Sustained activation of the tyrosine kinase Syk by antigen in mast cells requires local Ca2+ influx through Ca2+ release-activated Ca2+ (CRAC) channels

Mast cell activation involves cross-linking of IgE receptors followed by phosphorylation of the non-receptor tyrosine kinase Syk. This results in activation of the plasma membrane-bound enzyme phospholipase C1, which hydrolyses the minor membrane...

Authors: Ng SW, Dicapite JL, Singaravelu K, Parekh AB

Steroidal Androgens and Nonsteroidal, Tissue-Selective Androgen Receptor Modulator, S-22, Regulate Androgen Receptor Function through Distinct Genomic and Nongenomic Signaling Pathways

Androgen receptor (AR) ligands are important for the development and function of several tissues and organs. However, the poor oral bioavailability, pharmacokinetic properties, and receptor cross-reactivity of testosterone, coupled with side effects,...

Authors: Narayanan R, Coss CC, Yepuru M, Kearbey JD, Miller DD, Dalton JT

The transactivated EGF receptor recruits Pyk2 to regulate Src kinase activity

G-protein-coupled receptors such as the proteinase-activated receptor 1 (PAR1) induce phosphorylation of mitogen-activated protein kinases through multiple pathways including transactivation of receptor tyrosine kinases. In vascular smooth muscle...

Authors: Schauwienold D, Pérez Sastre A, Genzel N, Schaefer M, Reusch HP

Fusion of One twenty-two to BSAC (Basic, SAP, and coiled-coil domain) results in aberrant upregulation of transcriptional activity

OTT/RBM15-BSAC/MAL/MKL1/MRTF-A was identified as a fusion transcript generated by t(1;22)(p13;q13) in acute megakaryoblastic leukemia. Previous studies have shown that Basic, SAP, and coiled-coil domain (BSAC) activates the promoters containing CArG...

Authors: Sawada T, Nishiyama C, Kishi T, Sasazuki T, Komazawa-Sakon S, Xue X, Piao JH, Ogata H, Nakayama JI,...

cAMP-mediated Induction of Cyclin E Sensitizes Growth-arrested Adipose Stem Cells to DNA Damage-induced apoptosis

The differentiation capacity of mesenchymal stem cells has been extensively studied, but little is known on cell cycle-related events in the proliferation and differentiation phases of these cells. Here, we demonstrate that exposure to...

Authors: Ugland H, Boquest AC, Naderi S, Collas P, Blomhoff HK

Actin Filament Assembly by Myristoylated, Alanine-rich C Kinase Substrate-Phosphatidylinositol-4,5-diphosphate Signaling Is Critical for Dendrite Branching

Dendrites undergo extensive growth and branching at early stages, but relatively little is known about the molecular mechanisms underlying these processes. Here, we show that increasing the level of myristoylated, alanine-rich C kinase substrate...

Authors: Li H, Chen G, Zhou B, Duan S

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