Search Results

kappa Opioids inhibit tumor angiogenesis by suppressing VEGF signaling

Opioids are effective analgesics for the management of moderate to severe cancer pain. Here we show that kappa opioid receptor (KOR) agonists act as anti-angiogenic factors in tumors. Treatment with KOR agonists, U50,488H and TRK820, significantly...

Authors: Yamamizu K, Furuta S, Hamada Y, Yamashita A, Kuzumaki N, Narita M, Doi K, Katayama S, Nagase H,...

Mutations in the M-gene segment can substantially increase replication efficiency of NS1 deletion influenza A virus in MDCK cells.

Influenza viruses unable to express NS1 protein (delNS1) replicate poorly and induce large amounts of interferon (IFN). They are therefore considered candidate viruses for live-attenuated influenza vaccines. Their attenuated replication is generally...

Authors: van Wielink R1, Harmsen MM, Martens DE, Peeters BP, Wijffels RH, Moormann RJ.

Brain microvascular endothelial cells resist elongation due to curvature and shear stress

The highly specialized endothelial cells in brain capillaries are a key component of the blood-brain barrier, forming a network of tight junctions that almost completely block paracellular transport. In contrast to vascular endothelial cells in other...

Authors: Ye M, Sanchez HM, Hultz M, Yang Z, Bogorad M, Wong AD, Searson PC

Immunosuppressive effects of polyunsaturated fatty acids on antigen presentation by human leukocyte antigen class I molecules.

Dietary supplementation with polyunsaturated fatty acids (PUFAs) has immunosuppressive effects; however, the molecular targets of PUFAs and their mode of action remain unclear. One possible target is antigen presentation to T cells through the human...

Authors: Shaikh SR, Edidin M

SST Peer Reviewed

Comparative effectiveness of isolation techniques for contemporary Influenza A virus strains circulating in exhibition swine.

The current study sought to compare the effectiveness of 2 virus isolation methods for the recovery of contemporary Influenza A virus (FLUAV) strains circulating in swine at agricultural exhibitions. Following the emergence of the influenza A...

Authors: Bowman AS1, Nelson SW, Edwards JL, Hofer CC, Nolting JM, Davis IC, Slemons RD.

Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway

Evolutionarily conserved Notch signaling controls cell fate determination and differentiation during development, and is also essential for neovascularization in adults. Although recent studies suggest that the Notch pathway is associated with...

Authors: Yoshida Y, Hayashi Y, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Yamashita M,...

Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors.

The effects of soluble Nef protein on CD4(+) T cells were examined. CD4(+)-T-cell cultures exposed to soluble Nef were analyzed for apoptosis by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling and hallmarks of apoptosis...

Authors: James CO, Huang MB, Khan M, Garcia-Barrio M, Powell MD, Bond VC

SST Peer Reviewed

Unique responses of stem cell-derived vascular endothelial and mesenchymal cells to high levels of glucose

Diabetes leads to complications in selected organ systems, and vascular endothelial cell (EC) dysfunction and loss is the key initiating and perpetuating step in the development of these complications. Experimental and clinical studies have shown...

Authors: Keats E, Khan ZA

SST Peer Reviewed

Sensitive, multiplex and direct quantification of RNA sequences using a modified RASL assay.

A sensitive and highly multiplex method to directly measure RNA sequence abundance without requiring reverse transcription would be of value for a number of biomedical applications, including high throughput small molecule screening, pathogen...

Authors: Larman HB, Scott ER, Wogan M, Oliveira G, Torkamani A, Schultz PG

SST Peer Reviewed

MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis.

Dysregulation of epigenetic controls is associated with tumorigenesis in response to microenvironmental stimuli; however, the regulatory pathways involved in epigenetic dysfunction are largely unclear. We have determined that a critical epigenetic...

Authors: Chao CH, Chang CC, Wu MJ, Ko HW, Wang D, Hung MC, Yang JY, Chang CJ

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin

kappa Opioids inhibit tumor angiogenesis by suppressing VEGF signaling

Mutations in the M-gene segment can substantially increase replication efficiency of NS1 deletion influenza A virus in MDCK cells.

Brain microvascular endothelial cells resist elongation due to curvature and shear stress

Immunosuppressive effects of polyunsaturated fatty acids on antigen presentation by human leukocyte antigen class I molecules.

Comparative effectiveness of isolation techniques for contemporary Influenza A virus strains circulating in exhibition swine.

Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway

Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors.

Unique responses of stem cell-derived vascular endothelial and mesenchymal cells to high levels of glucose

Sensitive, multiplex and direct quantification of RNA sequences using a modified RASL assay.

MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis.