Search Results

Targeting interleukin-13 with tralokinumab attenuates lung fibrosis and epithelial damage in a humanized SCID idiopathic pulmonary fibrosis model

The aberrant fibrotic and repair responses in the lung are major hallmarks of idiopathic pulmonary fibrosis (IPF). Numerous antifibrotic strategies have been used in the clinic with limited success, raising the possibility that an effective...

Authors: Murray LA, Zhang H, Oak SR, Coelho AL, Herath A, Flaherty KR, Lee J, Bell M, Knight DA, Martinez FJ,...

DrCell – A Software Tool for the Analysis of Cell Signals Recorded with Extracellular Microelectrodes

Microelectrode arrays (MEAs) have been applied for in vivo and in vitro recording and stimulation of electrogenic cells, namely neurons and cardiac myocytes, for almost four decades. Extracellular recordings using the MEA technique inflict minimum...

Authors: Nick C, Goldhammer M, Bestel R, Steger F, Daus AW, Thielemann C

SST Peer Reviewed

Cellular inhibitor of apoptosis-2 is a critical regulator of apoptosis in airway epithelial cells treated with asthma-related inflammatory cytokines

Aberrant apoptosis of airway epithelial cells (AECs) is a disease contributing feature in the airways of asthmatics. The proinflammatory cytokines tumor necrosis factor a (TNFa) and interferon ? (IFN?) are increased in asthma and have been shown to...

Authors: Roscioli E, Hamon R, Ruffin RE, Lester S, Zalewski P

ELF4 is critical for induction of type I interferon and the host antiviral response.

Induction of type I interferon is a central event of innate immunity, essential for host defense. Here we report that the transcription factor ELF4 is induced by type I interferon and upregulates interferon expression in a feed-forward loop. ELF4...

Authors: You F, Wang P, Yang L, Yang G, Zhao YO, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A,...

SST Peer Reviewed

Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon ? and antiviral defense in airway epithelium

Viruses suppress host responses to increase infection, and understanding these mechanisms has provided insights into cellular signaling and led to novel therapies. Many viruses (e.g., Influenza virus, Rhinovirus [RV], Cytomegalovirus, Epstein-Barr...

Authors: Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL

Activity of PLCe contributes to chemotaxis of fibroblasts towards PDGF.

Cell chemotaxis, such as migration of fibroblasts towards growth factors during development and wound healing, requires precise spatial coordination of signalling events. Phosphoinositides and signalling enzymes involved in their generation and...

Authors: Martins M, Warren S, Kimberley C, Margineanu A, Peschard P, McCarthy A, Yeo M, Marshall CJ, Dunsby...

SST Peer Reviewed

Inhibition of protein phosphatase 2A activity by PI3K? regulates ß-adrenergic receptor function.

Phosphoinositide 3-kinase ? (PI3K?) is activated by G protein-coupled receptors (GPCRs). We show here that PI3K? inhibits protein phosphatase 2A (PP2A) at the ß-adrenergic receptor (ßAR, a GPCR) complex altering G protein coupling. PI3K? inhibition...

Authors: Vasudevan NT, Mohan ML, Gupta MK, Hussain AK, Naga Prasad SV.

SST Peer Reviewed

Type I collagen, fibrin and PuraMatrix matrices provide permissive environments for human endothelial and mesenchymal progenitor cells to form neovascular networks.

The field of tissue engineering seeks to create metabolically demanding, functional tissues, which will require blood vessel networks capable of forming rapidly in a variety of extracellular matrix (ECM) environments. We tested whether human...

Authors: Allen P, Melero-Martin J, Bischoff J.

SST Peer Reviewed

Growth of engineered human myocardium with mechanical loading and vascular coculture.

RATIONALE: The developing heart requires both mechanical load and vascularization to reach its proper size, yet the regulation of human heart growth by these processes is poorly understood. OBJECTIVE: We seek to elucidate the responses of immature...

Authors: Tulloch NL, Muskheli V, Razumova MV, Korte FS, Regnier M, Hauch KD, Pabon L, Reinecke H, Murry CE.

SST Peer Reviewed

The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose.

Abscisic acid (ABA) is a hormone involved in pivotal physiological functions in higher plants, such as response to abiotic stress and control of seed dormancy and germination. Recently, ABA was demonstrated to be autocrinally produced by human...

Authors: Scarfì S, Fresia C, Ferraris C, Bruzzone S, Fruscione F, Usai C, Benvenuto F, Magnone M, Podestà M,...

SST Peer Reviewed

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Targeting interleukin-13 with tralokinumab attenuates lung fibrosis and epithelial damage in a humanized SCID idiopathic pulmonary fibrosis model

DrCell – A Software Tool for the Analysis of Cell Signals Recorded with Extracellular Microelectrodes

Cellular inhibitor of apoptosis-2 is a critical regulator of apoptosis in airway epithelial cells treated with asthma-related inflammatory cytokines

ELF4 is critical for induction of type I interferon and the host antiviral response.

Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon ? and antiviral defense in airway epithelium

Activity of PLCe contributes to chemotaxis of fibroblasts towards PDGF.

Inhibition of protein phosphatase 2A activity by PI3K? regulates ß-adrenergic receptor function.

Type I collagen, fibrin and PuraMatrix matrices provide permissive environments for human endothelial and mesenchymal progenitor cells to form neovascular networks.

Growth of engineered human myocardium with mechanical loading and vascular coculture.

The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose.