Search Results

Basal lamina secreted by MDCK cells has size- and charge-selective properties.

The role electrical charge plays in determining glomerular permeability to macromolecules remains unclear. If the glomerular basement membrane (GBM) has any significant role in permselectivity, physical principles would suggest a negatively charged...

Authors: Ferrell N1, Groszek J, Li L, Smith R, Butler RS, Zorman CA, Roy S, Fissell WH

Differential cytotoxicity of long-chain bases for human oral keratinocytes, fibroblasts, dendritic and oral squamous cell carcinoma cell lines

Long-chain bases (sphingosine, dihydrosphingosine, and phytosphingosine) are present in the oral cavity and have potent antimicrobial activity against oral pathogens. However, little is known about their cytotoxicity for oral cells, an important step...

Authors: Poulsen C

SST Peer Reviewed

Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling

Establishment and stabilization of endothelial tubes with patent lumens is vital during vertebrate development. Ras-interacting protein 1 (RASIP1) has been described as an essential regulator of de novo lumenogenesis through modulation of endothelial...

Authors: Wilson CW, Parker LH, Hall CJ, Smyczek T, Mak J, Crow A, Posthuma G, De Mazière A, Sagolla M,...

Combinatorial effect of two framework mutations (E119V and I222L) in the neuraminidase active site of H3N2 influenza virus on resistance to oseltamivir.

Neuraminidase (NA) inhibitors (NIs) are the first line of defense against influenza virus. Reverse genetics experiments allow the study of resistance mechanisms by anticipating the impacts of mutations to the virus. To look at the possibility of an...

Authors: Richard M1, Ferraris O, Erny A, Barthélémy M, Traversier A, Sabatier M, Hay A, Lin YP, Russell RJ,...

Histatin 5 attenuates IL-8 dendritic cell response to gingivalis Hemagglutinin B

Histatins, a group of proteins produced by human salivary glands, have a variety of innate immune functions including the ability to: kill oral microorganisms, neutralize toxins, inactivate protease/collagenase activities, inhibit co-aggregation of...

Authors: Borgwardt DS

SST Peer Reviewed

Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.

GM-CSF is a potent proinflammatory cytokine that plays a pathogenic role in the CNS inflammatory disease experimental autoimmune encephalomyelitis. As IL-27 alleviates experimental autoimmune encephalomyelitis, we hypothesized that IL-27 suppresses...

Authors: Young A1, Linehan E, Hams E, O'Hara Hall AC, McClurg A, Johnston JA, Hunter CA, Fallon PG,...

Activation of Wnt11 by transforming growth factor-ß drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells.

Transforming growth factor ß1 (TGF-ß) promotes renal interstitial fibrosis in vivo and the expression of mesenchymal genes in vitro; however, most of its direct targets in epithelial cells are still elusive. In a screen for genes directly activated...

Authors: Zhang P1, Cai Y, Soofi A, Dressler GR.

Intracytoplasmic trapping of influenza virus by a lipophilic derivative of aglycoristocetin.

We report on a new anti-influenza virus agent, SA-19, a lipophilic glycopeptide derivative consisting of aglycoristocetin coupled to a phenylbenzyl-substituted cyclobutenedione. In Madin-Darby canine kidney cells infected with influenza A/H1N1,...

Authors: Vanderlinden E1, Vanstreels E, Boons E, ter Veer W, Huckriede A, Daelemans D, Van Lommel A, Roth E,...

MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1.

Systemic lupus erythematosus is a complex autoimmune disease caused by genetic and epigenetic alterations. DNA methylation abnormalities play an important role in systemic lupus erythematosus disease processes. MicroRNAs (miRNAs) have been implicated...

Authors: Pan W, Zhu S, Yuan M, Cui H, Wang L, Luo X, Li J, Zhou H, Tang Y, Shen N.

SST Peer Reviewed

EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes.

Treatment of hematopoietic malignancies often requires allogeneic bone marrow transplantation, and the subsequent graft-versus-leukemia response is crucial for the elimination of malignant cells. Cytotoxic T lymphocytes and NK cells responsible for...

Authors: Maddigan A, Truitt L, Arsenault R, Freywald T, Allonby O, Dean J, Narendran A, Xiang J, Weng A,...

SST Peer Reviewed

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Topic

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Origin

Basal lamina secreted by MDCK cells has size- and charge-selective properties.

Differential cytotoxicity of long-chain bases for human oral keratinocytes, fibroblasts, dendritic and oral squamous cell carcinoma cell lines

Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling

Combinatorial effect of two framework mutations (E119V and I222L) in the neuraminidase active site of H3N2 influenza virus on resistance to oseltamivir.

Histatin 5 attenuates IL-8 dendritic cell response to gingivalis Hemagglutinin B

Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.

Activation of Wnt11 by transforming growth factor-ß drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells.

Intracytoplasmic trapping of influenza virus by a lipophilic derivative of aglycoristocetin.

MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1.

EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes.