Search Results

Endotoxin-induced monocytic microparticles have contrasting effects on endothelial inflammatory responses.

Septic shock is a severe disease state characterised by the body's life threatening response to infection. Complex interactions between endothelial cells and circulating monocytes are responsible for microvasculature dysfunction contributing to the...

Authors: Wen B, Combes V, Bonhoure A, Weksler BB, Couraud PO, Grau GE.

Heat shock protein 90 inhibitors: new mode of therapy to overcome endocrine resistance

Aromatase inhibitors are important drugs to treat estrogen receptor alpha (ERalpha)-positive postmenopausal breast cancer patients. However, development of resistance to aromatase inhibitors has been observed. We examined whether the heat shock...

Authors: Wong C1, Chen S.

Human endothelial cell-based assay for endotoxin as sensitive as the conventional Limulus Amebocyte Lysate assay

Endotoxin, also known as lipopolysaccharide (LPS) produced by bacteria can be present in any liquid or on any biomaterial even if the material is sterile. Endotoxin in mammals can cause fever, inflammation, cell and tissue damage and irreversible...

Authors: Unger RE, Peters K, Sartoris A, Freese C, Kirkpatrick CJ

Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3

The accumulated uremic toxins inhibit the expression of various renal transporters and this inhibition may further reduce renal function and subsequently cause the accumulation of uremic toxins. However, the precise mechanism of the nephrotoxicity of...

Authors: Akiyama Y1, Kikuchi K, Saigusa D, Suzuki T, Takeuchi Y, Mishima E, Yamamoto Y, Ishida A, Sugawara D,...

Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis.

Although Wnt signaling activation is frequently observed in human breast cancer, mutations in genes encoding intracellular components of the Wnt signaling pathway are rare. We found that the expression of Wnt signaling co-receptor, LRP6, is...

Authors: Zhang J1, Li Y, Liu Q, Lu W, Bu G.

Dominant missense mutations in ABCC9 cause Cantú syndrome

Cantú syndrome is characterized by congenital hypertrichosis, distinctive facial features, osteochondrodysplasia and cardiac defects. By using family-based exome sequencing, we identified a de novo mutation in ABCC9. Subsequently, we discovered novel...

Authors: Harakalova M, van Harssel JJ, Terhal PA, van Lieshout S, Duran K, Renkens I, Amor DJ, Wilson LC,...

Role of cell-type-specific endoplasmic reticulum-associated degradation in polyomavirus trafficking

BK polyomavirus (BKPyV) is a widespread human pathogen that establishes a lifelong persistent infection and can cause severe disease in immunosuppressed patients. BKPyV is a nonenveloped DNA virus that must traffic through the endoplasmic reticulum...

Authors: Bennett SM1, Jiang M, Imperiale MJ

Derivation of neural progenitors and retinal pigment epithelium from common marmoset and human pluripotent stem cells

Embryonic and induced pluripotent stem cells (IPSCs) derived from mammalian species are valuable tools for modeling human disease, including retinal degenerative eye diseases that result in visual loss. Restoration of vision has focused on...

Authors: Torrez LB, Perez Y, Yang J, Zur Nieden NI, Klassen H, Liew CG.

Adenosine A2B receptors induce proliferation, invasion and activation of cAMP response element binding protein (CREB) in trophoblast cells.

BACKGROUND: Placental hypoxia is a result of abnormal and shallow trophoblast invasion and involved in the pathophysiology of preeclampsia. Hypoxia increases extracellular adenosine levels and plays an important role in the regulation of...

Authors: Darashchonak N, Koepsell B, Bogdanova N, von Versen-Höynck F.

Generation of neural progenitor cells by chemical cocktails and hypoxia

Neural progenitor cells (NPCs) can be induced from somatic cells by defined factors. Here we report that NPCs can be generated from mouse embryonic fibroblasts by a chemical cocktail, namely VCR (V, VPA, an inhibitor of HDACs; C, CHIR99021, an...

Authors: Cheng L1, Hu W1, Qiu B1, Zhao J1, Yu Y2, Guan W2, Wang M2, Yang W2, Pei G3

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin