Search Results

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

Eighteen histone deacetylases (HDACs) are present in humans, categorized into two groups: zinc-dependent enzymes (HDAC1-11) and NAD(+)-dependent enzymes (sirtuins 1-7). Among zinc-dependent HDACs, HDAC6 is unique. It has a cytoplasmic localization,...

Authors: Parmigiani RB, Xu WS, Venta-Perez G, Erdjument-Bromage H, Yaneva M, Tempst P, Marks PA

Vitamin D3 induces autophagy of human myeloid leukemia cells

Vitamin D3 causes potent suppression of various cancer cells; however, significant supraphysiological concentrations of this compound are required for antineoplastic effects. Current combinatorial therapies with vitamin D3 are restricted to...

Authors: Wang J, Lian H, Zhao Y, Kauss MA, Spindel S

Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma

Genetic lesions affecting a number of kinases and other elements within the epidermal growth factor receptor (EGFR) signaling pathway have been implicated in the pathogenesis of human non-small-cell lung cancer (NSCLC). We performed mutational...

Authors: Marks JL, Gong Y, Chitale D, Golas B, McLellan MD, Kasai Y, Ding L, Mardis ER, Wilson RK, Solit D,...

YY1 Protects Cardiac Myocytes from Pathologic Hypertrophy by Interacting with HDAC5

YY1 is a transcription factor that can repress or activate the transcription of a variety of genes. Here we show that YY1's function as a repressor in cardiac myocytes is tightly dependent on its ability to interact with histone deacetylase 5...

Authors: Sucharov CC, Dockstader K, McKinsey TA

The 9-1-1 DNA clamp is required for immunoglobulin gene conversion

Chicken DT40 cells deficient in the 9-1-1 checkpoint clamp exhibit hypersensitivity to a variety of DNA-damaging agents. Although recent work suggests that, in addition to its role in checkpoint activation, this complex may play a role in homologous...

Authors: Saberi A, Nakahara M, Sale JE, Kikuchi K, Arakawa H, Buerstedde JM, Takeda S, Sonoda E

Beta-PIX and Rac1 GTPase mediate trafficking and negative regulation of NOD2

The nucleotide-binding domain and leucine-rich repeat containing protein NOD2 serves as a cytoplasmic pattern recognition molecule sensing bacterial muramyl dipeptide (MDP), whereas TLR2 mediates cell surface recognition of bacterial lipopeptides. In...

Authors: Eitel J, Kruell M, Hocke AC, N'Guessan PD, Zahlten J, Schmeck B, Slevogt H, Hippenstiel S, Suttorp...

Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes

Nef induced podocyte proliferation and dedifferentiation via MAPK1,2 activation plays a role in HIV nephropathy pathogenesis. All-trans retinoic acid (atRA) reverses the HIV-induced podocyte phenotype by activating cAMP/PKA and inhibiting MAPK1,2....

Authors: Lu TC, Wang Z, Feng X, Chuang P, Fang W, Chen Y, Neves S, Maayan A, Xiong H, Liu Y, Iyengar R,...

SST Peer Reviewed

The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments

The neonatal Fc receptor for IgG (FcRn) transfers maternal IgG to the offspring and protects IgG from degradation. The FcRn resides in an acidic intracellular compartment, allowing it to bind IgG. In this study, we found the association of FcRn and...

Authors: Ye L, Liu X, Rout SN, Li Z, Yan Y, Lu L, Kamala T, Nanda NK, Song W, Samal SK, Zhu X

The role of Kalirin9 in p75/NgR-mediated RhoA activation in cerebellar granule neurons

P75 and the Nogo receptor (NgR) form a signaling unit for myelin-inhibitory molecules, with p75 being responsible for RhoA activation. Since p75 lacks the GEF domain, it has remained unclear how p75 activates RhoA. Here, we report that Kalirin 9, a...

Authors: Harrington AW, Li QM, Tep C, Park JB, He Z, Yoon SO

Activation of the Adenosine-A3 Receptor Stimulates Matrix Metalloproteinase-9 Secretion by Macrophages

AIMS: Matrix Metalloproteinase-9 (MMP-9) plays an important role in ventricular remodeling after acute myocardial infarction. The cardioprotectant adenosine may be involved in ventricular remodeling. We have shown that adenosine inhibits the...

Authors: Velot E, Haas B, Léonard F, Ernens I, Rolland-Turner M, Schwartz C, Longrois D, Devaux Y, Wagner DR

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