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High mobility group Box 1 inhibits human pulmonary artery endothelial cell migration via a Toll-like receptor 4- and interferon response factor 3-dependent mechanism(s).

In pulmonary hypertension the loss of precapillary arterioles results from vascular injury causing endothelial dysfunction. Endothelial cell migration and proliferation are critical for vascular regeneration. This study focused on the effect of high...

Authors: Bauer EM, Shapiro R, Billiar TR, Bauer PM.

Shortened ALK1 regulatory fragment maintains a specific activity in arteries feeding ischemic tissues.

Specific transgene induction in angiogenic blood vessels has been in demand in gene therapies for several cardiovascular and malignant proliferative diseases in which the vasculature is an essential part of the disease process. In addition to...

Authors: Li X, Yonenaga Y, Seki T.

Rap-afadin axis in control of Rho signaling and endothelial barrier recovery.

Activation of the Rho GTPase pathway determines endothelial cell (EC) hyperpermeability after injurious stimuli. To date, feedback mechanisms of Rho down-regulation critical for barrier restoration remain poorly understood. We tested a hypothesis...

Authors: Birukova AA, Tian X, Tian Y, Higginbotham K, Birukov KG.

BACKGROUND: Single circulating tumor cells (CTCs) or circulating tumor microemboli (CTMs) are potential biomarkers of renal cell cancer (RCC), however studies of CTCs/CTMs in RCC are limited. In this pilot study we aimed to evaluate a novel blood filtration technique suited for cytomorphological classification, immunocytochemical and molecular characterization of filtered, so called circulating non-hematologic cells (CNHCs) - putative CTCs/CTMs - in patients with RCC. METHODS: Blood of 40 patients with

BACKGROUND: Single circulating tumor cells (CTCs) or circulating tumor microemboli (CTMs) are potential biomarkers of renal cell cancer (RCC), however studies of CTCs/CTMs in RCC are limited. In this pilot study we aimed to evaluate a novel blood...

Authors: El-Heliebi A, Kroneis T, Zöhrer E, Haybaeck J, Fischereder K, Kampel-Kettner K, Zigeuner R, Pock H,...

Double-stranded RNA attenuates the barrier function of human pulmonary artery endothelial cells.

Circulating RNA may result from excessive cell damage or acute viral infection and can interact with vascular endothelial cells. Despite the obvious clinical implications associated with the presence of circulating RNA, its pathological effects on...

Authors: Bálint Z, Zabini D, Konya V, Nagaraj C, Végh AG, Váró G, Wilhelm I, Fazakas C, Krizbai IA, Heinemann...

Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium.

Authors: Agarwal B, Campen MJ, Channell MM, Wherry SJ, Varamini B, Davis JG, Baur JA, Smoliga JM.

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High mobility group Box 1 inhibits human pulmonary artery endothelial cell migration via a Toll-like receptor 4- and interferon response factor 3-dependent mechanism(s).

Shortened ALK1 regulatory fragment maintains a specific activity in arteries feeding ischemic tissues.

Rap-afadin axis in control of Rho signaling and endothelial barrier recovery.

Double-stranded RNA attenuates the barrier function of human pulmonary artery endothelial cells.

Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium.

Critical role of S1PR1 and integrin ß4 in HGF/c-Met-mediated increases in vascular integrity.

ON ANTIDIABETIC AGENTS AND THE VASCULATURE

ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells

BMP2 shows neurotrophic effects including neuroprotection against neurodegeneration.