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The hereditary hemochromatosis protein, HFE, inhibits iron uptake via downregulation of Zip14 in HEPG2 cells

Lack of functional hereditary hemochromatosis protein, HFE, causes iron overload predominantly in hepatocytes, the major site of HFE expression in the liver. In this study, we investigated the role of HFE on the regulation of both transferrin-bound...

Authors: Gao J, Zhao N, Knutson MD, Enns CA

Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages

TNF-alpha is a potent proinflammatory cytokine, essential for initiating innate immune responses against invading microbes and a key mediator involved in the pathogenesis of acute and chronic inflammatory diseases. To identify molecules involved in...

Authors: Ha SD, Martins A, Khazaie K, Han J, Chan BM, Kim SO

Dynamic protein associations define two phases of IL-1beta transcriptional activation

IL-1beta is a key proinflammatory cytokine with roles in multiple diseases. Monocytes package the IL-1beta promoter into a "poised architecture" characterized by a histone-free transcription start site and constitutive transcription factor...

Authors: Zhang Y, Saccani S, Shin H, Nikolajczyk BS

The MODY1 gene HNF4-alpha and a feedback loop control COUP-TFII expression in pancreatic beta cells

Pancreatic islet beta cell differentiation and function are dependent upon a group of transcription factors that maintain the expression of key genes and suppress others. Knockout mice with heterozygous deletion of the Chicken Ovalbumin Upstream...

Authors: Perilhou A, Tourrel-Cuzin C, Zhang P, Kharroubi I, Wang H, Fauveau V, Scott DK, Wollheim CB,...

Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system

In the central nervous system (CNS) of adult mammals, neurogenesis occurs in only two restricted areas, the subgranular zone (SGZ) of the hippocampus and the subventricular zone (SVZ). Isolation of multipotent progenitor cells from other CNS regions...

Authors: Jiao JW, Feldheim DA, Chen DF

IL-3 induced c-Fos activation is modulated by Gab2-calcineurin interaction

IL-3 regulates cell growth by affecting various processes such as cell death, survival and proliferation. Cues from the external environment are sensed by surface receptors, and complex signaling mechanisms within the cells lead to specific...

Authors: Pyarajan S, Matejovic G, Pratt JC, Baksh S, Burakoff SJ

Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer

Altered expression of microRNA (miRNA) is strongly implicated in cancer, and recent studies have shown that, in cancer, expression of some miRNAs cells is silenced in association with CpG island hypermethylation. To identify epigenetically silenced...

Authors: Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T

Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells

Killer Ig-like receptor (KIR) expression is mostly restricted to NK cells controlling their activation. With increasing age, KIRs are expressed on T cells and contribute to age-related diseases. We examined epigenetic mechanisms that determine the...

Authors: Li G, Weyand CM, Goronzy JJ

The roles of human sucrose nonfermenting protein 2 homologue in the tumor-promoting functions of Rsf-1

Rsf-1 interacts with human sucrose nonfermenting protein 2 homologue (hSNF2H) to form a chromatin remodeling complex that participates in several biological processes. We have previously shown that Rsf-1 gene amplification was associated with the...

Authors: Sheu JJ, Choi JH, Yildiz I, Tsai FJ, Shaul Y, Wang TL, Shih IeM

The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene

MicroRNAs (miRNAs) are noncoding RNAs that base pair imperfectly to homologous regions in target mRNAs and negatively influence the synthesis of the corresponding proteins. Repression is mediated by a number of mechanisms, one of which is the direct...

Authors: Kong YW, Cannell IG, de Moor CH, Hill K, Garside PG, Hamilton TL, Meijer HA, Dobbyn HC, Stoneley M,...

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