Search Results

TGF-beta 1 induces heparan sulfate 6-O-endosulfatase 1 expression in vitro and in vivo

Transforming growth factor (TGF)-ss1 plays an important role in the development of pulmonary fibrosis. In this study we examined the relationship between TGF-ss1 stimulation and the expression of heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) in...

Authors: Yue X, Li X, Nguyen HT, Chin DR, Sullivan DE, Lasky JA

An oncogenic role for the phosphorylated h-subunit of human translation initiation factor eIF3

Dysregulation of protein synthesis has been implicated in oncogenesis through a mechanism whereby "weak" mRNAs encoding proteins involved in cell proliferation are strongly translated when the protein synthesis apparatus is activated. Previous work...

Authors: Zhang L, Smit-McBride Z, Pan X, Rheinhardt J, Hershey JW

Molecular dissection of the human alpha 2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling

alpha(2)-Macroglobulin (alpha(2)M) is a plasma protease inhibitor, which reversibly binds growth factors and, in its activated form, binds to low density lipoprotein receptor-related protein (LRP-1), an endocytic receptor with cell-signaling...

Authors: Mantuano E, Mukandala G, Li X, Campana WM, Gonias SL

In vitro expression of erythropoietin by transfected human mesenchymal stromal cells

BACKGROUND: Mesenchymal stromal cells (MSC) are pluripotent progenitor cells that can be found in human bone marrow (BM). These cells have low immunogenicity and could suppress alloreactive T-cell responses. In the current study, MSC were tested for...

Authors: Mok PL, Cheong SK, Leong CF, Othman A

SST Peer Reviewed

Crosstalk between expression of the HTLV-1 Tax transactivator and the oncogenic bHLH transcription factor TAL1

The Human T cell Leukemia Virus type 1 (HTLV-1) Tax transactivator is known to induce or repress various cellular genes, several of them encoding transcription factors. As Tax is known to deregulate various bHLH factors, we looked more specifically...

Authors: Terme JM, Wencker M, Favre-Bonvin A, Bex F, Gazzolo L, Duc Dodon M, Jalinot P

Molecular and Genetic Analysis of Condensin Function in Vertebrate Cells

We engineered mutants into residues of SMC2 to dissect the role of ATPase function in the condensin complex. These residues are predicted to be involved in ATP binding or hydrolysis and in the Q-loop, which is thought to act as a mediator of...

Authors: Hudson DF, Ohta S, Freisinger T, Macisaac F, Sennels L, Alves F, Lai F, Kerr A, Rappsilber J,...

Molecular Dissection of the Structural Machinery Underlying the Tissue-invasive Activity of Membrane Type-1 Matrix Metalloproteinase

Membrane type-I matrix metalloproteinase (MT1-MMP) drives cell invasion through three-dimensional (3-D) extracellular matrix (ECM) barriers dominated by type I collagen or fibrin. Based largely on analyses of its impact on cell function under 2-D...

Authors: Li XY, Ota I, Yana I, Sabeh F, Weiss SJ

Molecular Basis of Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) Cytotoxicity in EBV Latency III B-cells: LMP1 induces type II Ligand independent Autoactivation of CD95/Fas with Caspase-8 mediated Apoptosis

Epstein-Barr-Virus (EBV) oncoprotein LMP1 (Latent Membrane Protein 1) is thought to be the major transforming protein in various cell types, by rerouting the TNF receptor family signalling pathway. Despite this implication in EBV-associated...

Authors: Le Clorennec C, Ouk TS, Youlyouz-Marfak I, Panteix S, Martin CC, Rastelli J, Adriaenssens E,...

Rapid leukocyte migration by integrin-independent flowing and squeezing

All metazoan cells carry transmembrane receptors of the integrin family, which couple the contractile force of the actomyosin cytoskeleton to the extracellular environment. In agreement with this principle, rapidly migrating leukocytes use...

Authors: Laemmermann T, Bader BL, Monkley SJ, Worbs T, Wedlich-Söldner R, Hirsch K, Keller M, Förster R,...

MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis

Phagocytosis and subsequent degradation of pathogens by macrophages play a pivotal role in host innate immune responses to microbial infection. Recent studies have shown that Toll-like receptors (TLRs) play an important role in promoting the...

Authors: Kong L, Ge BX

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