Search Results

Identification of a small molecule activator of SIRT1 gene expression

Increased SIRT1 expression exerts beneficial effects in transgenic animal models, ameliorating the onset and progression of aging-related disease phenotypes in various organs including the heart. The potential beneficial effects of SIRT1 have made...

Authors: Cho SY, Cho M, Seo DB, Lee SJ, Suh Y

Growth of engineered human myocardium with mechanical loading and vascular coculture.

RATIONALE: The developing heart requires both mechanical load and vascularization to reach its proper size, yet the regulation of human heart growth by these processes is poorly understood. OBJECTIVE: We seek to elucidate the responses of immature...

Authors: Tulloch NL, Muskheli V, Razumova MV, Korte FS, Regnier M, Hauch KD, Pabon L, Reinecke H, Murry CE.

SST Peer Reviewed

Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells

Mesenchymal stem cells natively circulating or delivered into the blood stream home to sites of injury. The mechanism of mesenchymal stem cell homing to sites of injury is poorly understood. We have shown that the development of apoptosis in...

Authors: Potapova IA, Cohen IS, Doronin SV

SST Peer Reviewed

Overexpression of STARD3 in human monocyte/macrophages induces an anti-atherogenic lipid phenotype.

Dysregulated macrophage cholesterol homoeostasis lies at the heart of early and developing atheroma, and removal of excess cholesterol from macrophage foam cells, by efficient transport mechanisms, is central to stabilization and regression of...

Authors: Borthwick F, Allen AM, Taylor JM, Graham A

SST Peer Reviewed

High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway

In diabetes, some of the cellular changes are similar to aging. We hypothesized that hyperglycemia accelerates aging-like changes in the endothelial cells (ECs) and tissues leading to structural and functional damage. We investigated glucose-induced...

Authors: Mortuza R, Chen S, Feng B, Sen S, Chakrabarti S

Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression.

Zaire ebolavirus (ZEBOV) infections are associated with high lethality in primates. ZEBOV primarily targets mononuclear phagocytes, which are activated upon infection and secrete mediators believed to trigger initial stages of pathogenesis. The...

Authors: Wahl-Jensen V, Kurz S, Feldmann F, Buehler LK, Kindrachuk J, DeFilippis V, da Silva Correia J, Früh...

SST Peer Reviewed

Isoelectric focusing in agarose gel for detection of oligoclonal bands in cerebrospinal and other biological fluids

Isoelectric focusing (IEF) coupled with immunodetection (immunofixation or immunoblotting) has become the leading technique for the detection and study of oligoclonal bands (OCBs) in cerebrospinal fluid (CSF) and also is increasingly used in other...

Authors: Csako G.

Effects of vascular endothelial growth factor on endothelin-1 production by human lung microvascular endothelial cells in vitro

AIMS: Increased endothelin-1 (ET-1) is a hallmark of pulmonary arterial hypertension (PAH), and contributes to its pathogenesis. The factors controlling ET-1 in PAH are poorly understood. Combined with other stimuli, vascular endothelial growth...

Authors: Star GP, Giovinazzo M, Lamoureux E, Langleben D

Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell

Vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), P- and E-selectin play a pivotal role for initiation of atherosclerosis. Ginsenoside, a class of steroid glycosides, is abundant in Panax ginseng root, which has...

Authors: Cho YS, Kim CH, Ha TS, Lee SJ, Ahn HY

Relevant shaking stress conditions for antibody preformulation development.

In protein formulation development, shaking stress is often employed to assess the physical stability of antibody formulations against aggregation. Since there are currently no guidelines describing suitable test conditions, very different shaking...

Authors: Eppler A, Weigandt M, Hanefeld A, Bunjes H.

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Identification of a small molecule activator of SIRT1 gene expression

Growth of engineered human myocardium with mechanical loading and vascular coculture.

Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells

Overexpression of STARD3 in human monocyte/macrophages induces an anti-atherogenic lipid phenotype.

High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway

Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression.

Isoelectric focusing in agarose gel for detection of oligoclonal bands in cerebrospinal and other biological fluids

Effects of vascular endothelial growth factor on endothelin-1 production by human lung microvascular endothelial cells in vitro

Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell

Relevant shaking stress conditions for antibody preformulation development.