Search Results

Percutaneous cell delivery into the heart using hydrogels polymerizing in situ.

Heart disease is the leading cause of death in the US. Following an acute myocardial infarction, a fibrous, noncontractile scar develops, and results in congestive heart failure in more than 500,000 patients in the US each year. Muscle regeneration...

Authors: Martens TP, Godier AF, Parks JJ, Wan LQ, Koeckert MS, Eng GM, Hudson BI, Sherman W, Vunjak-Novakovic...

SST Peer Reviewed

DrCell – A Software Tool for the Analysis of Cell Signals Recorded with Extracellular Microelectrodes

Microelectrode arrays (MEAs) have been applied for in vivo and in vitro recording and stimulation of electrogenic cells, namely neurons and cardiac myocytes, for almost four decades. Extracellular recordings using the MEA technique inflict minimum...

Authors: Nick C, Goldhammer M, Bestel R, Steger F, Daus AW, Thielemann C

SST Peer Reviewed

Human pericytes for ischemic heart repair

Human microvascular pericytes (CD146(+)/34(-)/45(-)/56(-)) contain multipotent precursors and repair/regenerate defective tissues, notably skeletal muscle. However, their ability to repair the ischemic heart remains unknown. We investigated the...

Authors: Chen CW, Okada M, Proto JD, Gao X, Sekiya N, Beckman SA, Corselli M, Crisan M, Saparov A, Tobita K,...

Sphingoid bases induce dose-dependent cytotoxicity and cytokine responses in human myeloid dendritic cells

Sphingoid bases (sphingosine, dihydrosphingosine and phytosphingosine) have been recently found in the oral cavity where they may serve to fortify innate immunity against commensals and periodontal pathogens. In fact, sphingoid bases have potent...

Authors: Mehalick LA

SST Peer Reviewed

ELF4 is critical for induction of type I interferon and the host antiviral response.

Induction of type I interferon is a central event of innate immunity, essential for host defense. Here we report that the transcription factor ELF4 is induced by type I interferon and upregulates interferon expression in a feed-forward loop. ELF4...

Authors: You F, Wang P, Yang L, Yang G, Zhao YO, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A,...

SST Peer Reviewed

Increased circulation of galectin-3 in cancer induces secretion of metastasis-promoting cytokines from blood vascular endothelium

PURPOSE: Cytokines such as interleukin (IL)-6 and granulocyte colony-stimulating factor (G-CSF) are important metastasis promoters. This study has investigated the functional significance of the increased circulation of galectin-3, a common feature...

Authors: Chen C, Duckworth CA, Zhao Q, Pritchard DM, Rhodes JM, Yu LG

Activity of PLCe contributes to chemotaxis of fibroblasts towards PDGF.

Cell chemotaxis, such as migration of fibroblasts towards growth factors during development and wound healing, requires precise spatial coordination of signalling events. Phosphoinositides and signalling enzymes involved in their generation and...

Authors: Martins M, Warren S, Kimberley C, Margineanu A, Peschard P, McCarthy A, Yeo M, Marshall CJ, Dunsby...

SST Peer Reviewed

In vivo and in vitro characterization of the angiogenic effect of CTX0E03 human neural stem cells

CTX0E03 is a human neural stem cell line previously reported to reduce sensory motor deficits in a middle cerebral artery occlusion (MCAo) model of stroke. The objective of this study was to investigate if CTX0E03 treatment promotes angiogenesis. As...

Authors: Hicks C, Stevanato L, Stroemer RP, Tang E, Richardson S, Sinden JD

Expression and differentiation between OCT4A and its Pseudogenes in human ESCs and differentiated adult somatic cells

The POU5F1 gene codes for the OCT4 transcription factor, which is one of the key regulators of pluripotency. Its transcription, alternative splicing, and alternative translation leading to the synthesis of the active, nuclear localized OCT4A has been...

Authors: Jez M, Ambady S, Kashpur O, Grella A, Malcuit C, Vilner L, Rozman P, Dominko T

Inhibition of protein phosphatase 2A activity by PI3K? regulates ß-adrenergic receptor function.

Phosphoinositide 3-kinase ? (PI3K?) is activated by G protein-coupled receptors (GPCRs). We show here that PI3K? inhibits protein phosphatase 2A (PP2A) at the ß-adrenergic receptor (ßAR, a GPCR) complex altering G protein coupling. PI3K? inhibition...

Authors: Vasudevan NT, Mohan ML, Gupta MK, Hussain AK, Naga Prasad SV.

SST Peer Reviewed

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Percutaneous cell delivery into the heart using hydrogels polymerizing in situ.

DrCell – A Software Tool for the Analysis of Cell Signals Recorded with Extracellular Microelectrodes

Human pericytes for ischemic heart repair

Sphingoid bases induce dose-dependent cytotoxicity and cytokine responses in human myeloid dendritic cells

ELF4 is critical for induction of type I interferon and the host antiviral response.

Increased circulation of galectin-3 in cancer induces secretion of metastasis-promoting cytokines from blood vascular endothelium

Activity of PLCe contributes to chemotaxis of fibroblasts towards PDGF.

In vivo and in vitro characterization of the angiogenic effect of CTX0E03 human neural stem cells

Expression and differentiation between OCT4A and its Pseudogenes in human ESCs and differentiated adult somatic cells

Inhibition of protein phosphatase 2A activity by PI3K? regulates ß-adrenergic receptor function.