Search Results

Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis.

Objective: The aim of this study was to monitor the effectiveness of root canal procedures by using different irrigants and intracanal medication on endotoxin levels found in root canals of teeth with chronic apical periodontitis. Material and...

Authors: Marinho AC, Martinho FC, Zaia AA, Ferraz CC, Gomes BP.

Reconstruction of monocyte transcriptional regulatory network accompanies monocytic functions in human fibroblasts.

Transcriptional regulatory networks (TRN) control the underlying mechanisms behind cellular functions and they are defined by a set of core transcription factors regulating cascades of peripheral genes. Here we report SPI1, CEBPA, MNDA and IRF8 as...

Authors: Suzuki T, Nakano-Ikegaya M, Yabukami-Okuda H, de Hoon M, Severin J, Saga-Hatano S, Shin JW, Kubosaki...

SST Peer Reviewed

ß-adrenergic signaling inhibits Gq-dependent protein kinase D activation by preventing protein kinase D translocation.

Both ß-adrenergic receptor (ß-AR) and Gq-coupled receptor (GqR) agonist-driven signaling play key roles in the events, leading up to and during cardiac dysfunction. How these stimuli interact at the level of protein kinase D (PKD), a nodal point in...

Authors: Nichols CB, Chang CW, Ferrero M, Wood BM, Stein ML, Ferguson AJ, Ha D, Rigor RR, Bossuyt S, Bossuyt...

SST Peer Reviewed

Enhancement of mitochondrial biogenesis with polyphenols: combined effects of resveratrol and equol in human endothelial cells

Emerging evidence suggests that combinatorial action of numerous biologically active compounds may be a valuable source in a variety of therapeutic applications. Several nutraceuticals have demonstrated to augment the efficacy of pharmacological...

Authors: Davinelli S, Sapere N, Visentin M, Zella D, Scapagnini G

Endotoxemia is associated with altered innate and adaptive immune responses in untreated HIV-1 infected individuals.

BACKGROUND: Microbial translocation may contribute to the immunopathogenesis in HIV infection. We investigated if microbial translocation and inflammation were associated with innate and adaptive immune responses in adults with HIV....

Authors: Bukh AR1, Melchjorsen J, Offersen R, Jensen JM, Toft L, Støvring H, Ostergaard L, Tolstrup M,...

Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury.

Neointimal hyperplasia is the primary lesion underlying atherosclerosis and restenosis after percutaneous coronary intervention. Calcitonin gene-related peptide (CGRP) is produced by alternative splicing of the primary transcript of the...

Authors: Yang L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Iesato Y, Uetake...

SST Peer Reviewed

Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration

Lymphocyte trafficking and migration through vascular endothelial cells (ECs) in secondary lymphoid tissues is critical for immune protection. In the present study, we investigate the role of nectin cell adhesion molecules for the migration of...

Authors: Devilard E, Xerri L, Dubreuil P, Lopez M, Reymond N

Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH oxidase 1.

OBJECTIVE: Although the matricellular protein thrombospondin-1 (TSP1) is highly expressed in the vessel wall in response to injury, its pathophysiological role in the development of vascular disease is poorly understood. This study was designed to...

Authors: Csányi G, Yao M, Rodríguez AI, Al Ghouleh I, Sharifi-Sanjani M, Frazziano G, Huang X, Kelley EE,...

SST Peer Reviewed

High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects.

OBJECTIVE: To evaluate the changes in circulating endotoxin after a high-saturated fat meal to determine whether these effects depend on metabolic disease state. RESEARCH DESIGN AND METHODS: Subjects (n = 54) were given a high-fat meal (75...

Authors: Harte AL1, Varma MC, Tripathi G, McGee KC, Al-Daghri NM, Al-Attas OS, Sabico S, O\\\'Hare JP,...

Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF-dependent manner.

Human endothelial progenitor cells (hEPCs) participate in neovascularization of ischemic tissues. Function and number of hEPCs decline in patients with cardiovascular disease, and therapeutic strategies to enhance hEPC function remain an important...

Authors: Gherghe CM, Duan J, Gong J, Rojas M, Klauber-Demore N, Majesky M, Deb A.

SST Peer Reviewed

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Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis.

Reconstruction of monocyte transcriptional regulatory network accompanies monocytic functions in human fibroblasts.

ß-adrenergic signaling inhibits Gq-dependent protein kinase D activation by preventing protein kinase D translocation.

Enhancement of mitochondrial biogenesis with polyphenols: combined effects of resveratrol and equol in human endothelial cells

Endotoxemia is associated with altered innate and adaptive immune responses in untreated HIV-1 infected individuals.

Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury.

Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration

Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH oxidase 1.

High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects.

Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF-dependent manner.