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Identification of a small molecule activator of SIRT1 gene expression

Increased SIRT1 expression exerts beneficial effects in transgenic animal models, ameliorating the onset and progression of aging-related disease phenotypes in various organs including the heart. The potential beneficial effects of SIRT1 have made...

Authors: Cho SY, Cho M, Seo DB, Lee SJ, Suh Y

Measurement of endotoxins in bioaerosols at workplace: a critical review of literature and a standardization issue.

Endotoxins are lipopolysaccharides found in the outer membrane of most Gram-negative bacteria and cyanobacteria. Worker exposure to endotoxins has been shown in a number of work situations and is associated with both respiratory and systemic...

Authors: Duquenne P1, Marchand G, Duchaine C.

Overexpression of STARD3 in human monocyte/macrophages induces an anti-atherogenic lipid phenotype.

Dysregulated macrophage cholesterol homoeostasis lies at the heart of early and developing atheroma, and removal of excess cholesterol from macrophage foam cells, by efficient transport mechanisms, is central to stabilization and regression of...

Authors: Borthwick F, Allen AM, Taylor JM, Graham A

SST Peer Reviewed

Heparin disrupts the CXCR4/SDF-1 axis and impairs the functional capacity of bone marrow-derived mononuclear cells used for cardiovascular repair.

RATIONALE: Cell therapy is a promising option for the treatment of acute or chronic myocardial ischemia. The intracoronary infusion of cells imposes the potential risk of cell clotting, which may be prevented by the addition of anticoagulants....

Authors: Seeger FH, Rasper T, Fischer A, Muhly-Reinholz M, Hergenreider E, Leistner DM, Sommer K, Manavski Y,...

SST Peer Reviewed

Dietary oil composition differentially modulates intestinal endotoxin transport and postprandial endotoxemia.

BACKGROUND: Intestinal derived endotoxin and the subsequent endotoxemia can be considered major predisposing factors for diseases such as atherosclerosis, sepsis, obesity and diabetes. Dietary fat has been shown to increase postprandial...

Authors: Mani V1, Hollis JH, Gabler NK.

Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression.

Zaire ebolavirus (ZEBOV) infections are associated with high lethality in primates. ZEBOV primarily targets mononuclear phagocytes, which are activated upon infection and secrete mediators believed to trigger initial stages of pathogenesis. The...

Authors: Wahl-Jensen V, Kurz S, Feldmann F, Buehler LK, Kindrachuk J, DeFilippis V, da Silva Correia J, Früh...

SST Peer Reviewed

COMP-Ang1 stimulates HIF-1a-mediated SDF-1 overexpression and recovers ischemic injury through BM-derived progenitor cell recruitment.

Recruitment and adhesion of bone marrow (BM)-derived circulating progenitor cells to ischemic tissue are important for vasculogenesis and tissue repair. Recently, we found cartilage oligomeric matrix protein (COMP)-Ang1 is a useful cell-priming agent...

Authors: Youn SW, Lee SW, Lee J, Jeong HK, Suh JW, Yoon CH, Kang HJ, Kim HZ, Koh GY, Oh BH, Park YB, Kim HS.

SST Peer Reviewed

Recombinant factor C (rFC) assay and gas chromatography/mass spectrometry (GC/MS) analysis of endotoxin variability in four agricultural dusts.

Endotoxin exposure is a significant concern in agricultural environments due to relatively high exposure levels. The goals of this study were to determine patterns of 3-hydroxy fatty acid (3-OHFA) distribution in dusts from four types of agricultural...

Authors: Saito R1, Cranmer BK, Tessari JD, Larsson L, Mehaffy JM, Keefe TJ, Reynolds SJ.

Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell

Vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), P- and E-selectin play a pivotal role for initiation of atherosclerosis. Ginsenoside, a class of steroid glycosides, is abundant in Panax ginseng root, which has...

Authors: Cho YS, Kim CH, Ha TS, Lee SJ, Ahn HY

Interpretation of Cellular Imaging and AQP4 Quantification Data in a Single Cell Simulator

The goal of the present study is to integrate different datasets in cell biology to derive additional quantitative information about a gene or protein of interest within a single cell using computational simulations. We propose a novel prototype cell...

Authors: Kim SB, Hsu Y, Linninger AA

SST Peer Reviewed

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Identification of a small molecule activator of SIRT1 gene expression

Measurement of endotoxins in bioaerosols at workplace: a critical review of literature and a standardization issue.

Overexpression of STARD3 in human monocyte/macrophages induces an anti-atherogenic lipid phenotype.

Heparin disrupts the CXCR4/SDF-1 axis and impairs the functional capacity of bone marrow-derived mononuclear cells used for cardiovascular repair.

Dietary oil composition differentially modulates intestinal endotoxin transport and postprandial endotoxemia.

Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression.

COMP-Ang1 stimulates HIF-1a-mediated SDF-1 overexpression and recovers ischemic injury through BM-derived progenitor cell recruitment.

Recombinant factor C (rFC) assay and gas chromatography/mass spectrometry (GC/MS) analysis of endotoxin variability in four agricultural dusts.

Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell

Interpretation of Cellular Imaging and AQP4 Quantification Data in a Single Cell Simulator