Search Results

Altered hMSC functional characteristics in short-term culture and when placed in low oxygen environments: implications for cell retention at physiologic sites

BACKGROUND: It is very difficult to conserve critical cell characteristics during expansion in culture, particularly those of adult mesenchymal stromal cells (MSCs), whose characteristics can change rapidly even within a short period of expansion....

Authors: Bain O, Detela G, Kim HW, Mason C, Mathur A, Wall IB

Expression pattern of the thioredoxin system in human endothelial progenitor cells and endothelial cells under hypoxic injury.

BACKGROUND AND OBJECTIVES: The thioredoxin (TRx) system is a ubiquitous thiol oxidoreductase pathway that regulates cellular reduction/oxidation status. Although endothelial cell (EC) hypoxic damage is one of the important pathophysiologic...

Authors: Park KJ, Kim YJ, Choi EJ, Park NK, Kim GH, Kim SM, Lee SY, Bae JW, Hwang KK, Kim DW, Cho MC.

SST Peer Reviewed

Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling

Angiogenesis defines the process in which new vessels grow from existing vessels. Using the mouse retina as a model system, we show that cysteine-rich motor neuron 1 (Crim1), a type I transmembrane protein, is highly expressed in angiogenic...

Authors: Fan J, Ponferrada VG, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang RA

Microbial translocation contribute to febrile episodes in adults with chemotherapy-induced neutropenia.

In this study we sought to determine the contribution of microbial translocation to febrile episodes with no attributable microbiological cause (Fever of Unknown Origin, FUO) in an adult febrile neutropaenic cohort. Endotoxin concentrations were...

Authors: Wong M1, Barqasho B, Ohrmalm L, Tolfvenstam T, Nowak P.

Highly Efficient Transfection of Human THP-1 Macrophages by Nucleofection.

Macrophages, as key players of the innate immune response, are at the focus of research dealing with tissue homeostasis or various pathologies. Transfection with siRNA and plasmid DNA is an efficient tool for studying their function, but transfection...

Authors: Maeß MB, Wittig B, Lorkowski S

SST Peer Reviewed

Noninvasive metabolic imaging of engineered 3D human adipose tissue in a perfusion bioreactor

The efficacy and economy of most in vitro human models used in research is limited by the lack of a physiologically-relevant three-dimensional perfused environment and the inability to noninvasively quantify the structural and biochemical...

Authors: Ward A, Quinn KP, Bellas E, Georgakoudi I, Kaplan DL

Airborne microorganisms, endotoxin, and dust concentration in wood factories in Italy.

Exposure to biological agents and dusts occurs in homes and occupational environments and it is known to cause adverse health effects. There is limited information concerning the occupational exposure levels of airborne biohazard during wood...

Authors: Gioffrè A1, Marramao A, Iannò A.

O2 level controls hematopoietic circulating progenitor cells differentiation into endothelial or smooth muscle cells.

BACKGROUND: Recent studies showed that progenitor cells could differentiate into mature vascular cells. The main physiological factors implicated in cell differentiation are specific growth factors. We hypothesized that simply by varying the...

Authors: Berthelemy N, Kerdjoudj H, Schaaf P, Prin-Mathieu C, Lacolley P, Stoltz JF, Voegel JC, Menu P.

SST Peer Reviewed

Comparison of angiogenic, cytoprotective, and immunosuppressive properties of human amnion- and chorion-derived mesenchymal stem cells

Although mesenchymal stem cells (MSCs) can be obtained from the fetal membrane (FM), little information is available regarding biological differences in MSCs derived from different layers of the FM or their therapeutic potential. Isolated MSCs from...

Authors: Yamahara K, Harada K, Ohshima M, Ishikane S, Ohnishi S, Tsuda H, Otani K, Taguchi A, Soma T, Ogawa...

Blood outgrowth endothelial cells from cord blood and peripheral blood: angiogenesis-related characteristics in vitro.

BACKGROUND: Blood outgrowth endothelial cells (BOEC) are good candidates for vascular (re-) generating cell therapy. Although cord blood (CB) BOEC have been reported as more proliferative than peripheral blood (PB) BOEC, not much is known about...

Authors: van Beem RT, Verloop RE, Kleijer M, Noort WA, Loof N, Koolwijk P, van der Schoot CE, van Hinsbergh...

SST Peer Reviewed

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Altered hMSC functional characteristics in short-term culture and when placed in low oxygen environments: implications for cell retention at physiologic sites

Expression pattern of the thioredoxin system in human endothelial progenitor cells and endothelial cells under hypoxic injury.

Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling

Microbial translocation contribute to febrile episodes in adults with chemotherapy-induced neutropenia.

Highly Efficient Transfection of Human THP-1 Macrophages by Nucleofection.

Noninvasive metabolic imaging of engineered 3D human adipose tissue in a perfusion bioreactor

Airborne microorganisms, endotoxin, and dust concentration in wood factories in Italy.

O2 level controls hematopoietic circulating progenitor cells differentiation into endothelial or smooth muscle cells.

Comparison of angiogenic, cytoprotective, and immunosuppressive properties of human amnion- and chorion-derived mesenchymal stem cells

Blood outgrowth endothelial cells from cord blood and peripheral blood: angiogenesis-related characteristics in vitro.