Search Results

Recombinant factor C (rFC) assay and gas chromatography/mass spectrometry (GC/MS) analysis of endotoxin variability in four agricultural dusts.

Endotoxin exposure is a significant concern in agricultural environments due to relatively high exposure levels. The goals of this study were to determine patterns of 3-hydroxy fatty acid (3-OHFA) distribution in dusts from four types of agricultural...

Authors: Saito R1, Cranmer BK, Tessari JD, Larsson L, Mehaffy JM, Keefe TJ, Reynolds SJ.

Down-regulation of the Antisense Mitochondrial ncRNAs is a Unique Vulnerability of Cancer Cells and a Potential Target for Cancer Therapy

Hallmarks of cancer are fundamental principles involved in cancer progression. We propose an additional generalized hallmark of malignant transformation, corresponding to the differential expression of a family of mitochondrial ncRNAs (ncmtRNAs),...

Authors: Vidaurre S1, Fitzpatrick C2, Burzio VA3, Briones M2, Villota C2, Villegas J2, Echenique J2,...

Cutaneous tumors cease CXCL9/Mig production as a result of IFN-?-mediated immunoediting.

During growth in the host, tumor cells are subjected to the stresses of innate and adaptive immunity (immunoediting), which provoke epigenetic changes in the tumor and increase tumor resistance to these immune responses. Our recent studies in...

Authors: Petro M1, Kish D, Guryanova OA, Ilyinskaya G, Kondratova A, Fairchild RL, Gorbachev AV.

Metformin protects cardiomyocyte from doxorubicin induced cytotoxicity through an AMP-activated protein kinase dependent signaling pathway: an in vitro study.

Doxorubicin (Dox) is one of the most widely used antitumor drugs, but its cumulative cardiotoxicity have been major concerns in cancer therapeutic practice for decades. Recent studies established that metformin (Met), an oral anti-diabetic drug,...

Authors: Kobashigawa LC, Xu YC, Padbury JF, Tseng YT, Yano N.

SST Peer Reviewed

DA-6034 Induces [Ca(2+)]i Increase in Epithelial Cells

DA-6034, a eupatilin derivative of flavonoid, has shown potent effects on the protection of gastric mucosa and induced the increases in fluid and glycoprotein secretion in human and rat corneal and conjunctival cells, suggesting that it might be...

Authors: Yang YM1, Park S1, Ji H1, Kim TI2, Kim EK2, Kang KK3, Shin DM1.

Monitoring the effectiveness of root canal procedures on endotoxin levels found in teeth with chronic apical periodontitis.

Objective: The aim of this study was to monitor the effectiveness of root canal procedures by using different irrigants and intracanal medication on endotoxin levels found in root canals of teeth with chronic apical periodontitis. Material and...

Authors: Marinho AC, Martinho FC, Zaia AA, Ferraz CC, Gomes BP.

Endotoxemia is associated with altered innate and adaptive immune responses in untreated HIV-1 infected individuals.

BACKGROUND: Microbial translocation may contribute to the immunopathogenesis in HIV infection. We investigated if microbial translocation and inflammation were associated with innate and adaptive immune responses in adults with HIV....

Authors: Bukh AR1, Melchjorsen J, Offersen R, Jensen JM, Toft L, Støvring H, Ostergaard L, Tolstrup M,...

TSG-6 protein is crucial for the development of pulmonary hyaluronan deposition, eosinophilia, and airway hyperresponsiveness in a murine model of asthma.

Hyaluronan (HA) deposition is often correlated with mucosal inflammatory responses, where HA mediates both protective and pathological responses. By modifying the HA matrix, Tnfip6 (TNF-a-induced protein-6; also known as TSG-6 (TNF-stimulated...

Authors: Swaidani S1, Cheng G, Lauer ME, Sharma M, Mikecz K, Hascall VC, Aronica MA.

High fat intake leads to acute postprandial exposure to circulating endotoxin in type 2 diabetic subjects.

OBJECTIVE: To evaluate the changes in circulating endotoxin after a high-saturated fat meal to determine whether these effects depend on metabolic disease state. RESEARCH DESIGN AND METHODS: Subjects (n = 54) were given a high-fat meal (75...

Authors: Harte AL1, Varma MC, Tripathi G, McGee KC, Al-Daghri NM, Al-Attas OS, Sabico S, O\\\'Hare JP,...

Neutrophil expression of Fas ligand and perforin directs effector CD8 T cell infiltration into antigen-challenged skin.

Contact hypersensitivity (CHS) is a T cell response to hapten skin challenge of sensitized individuals proposed to be mediated by hapten-primed CD8 cytolytic T cells. Effector CD8 T cell recruitment into hapten challenge sites to elicit CHS requires...

Authors: Kish DD1, Gorbachev AV, Parameswaran N, Gupta N, Fairchild RL.

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