Search Results

Barrier responses of human bronchial epithelial cells to grass pollen exposure.

The airway epithelium forms a physical, chemical and immunological barrier against inhaled environmental substances. In asthma, these barrier properties are thought to be abnormal. In this study, we analysed the effect of grass pollen on the physical...

Authors: Blume C, Swindle EJ, Dennison P, Jayasekera NP, Dudley S, Monk P, Behrendt H, Schmidt-Weber CB,...

Endotoxin neutralization as a biomonitor for inflammatory bowel disease.

Gram-negative bacterial endotoxin is a potent immunostimulant implicated in the development and/or progression of a variety of diseases. The mammalian immune system has both innate and adaptive immune responses to neutralize endotoxin. In this study,...

Authors: Champion K1, Chiu L, Ferbas J, Pepe M.

Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-ß1

BACKGROUND: We have previously shown that transforming growth factor-beta (TGF-beta) impairs glucocorticoid (GC) function in pulmonary epithelial cell-lines. However, the signalling cascade leading to this impairment is unknown. In the present study,...

Authors: Keenan CR, Mok JS, Harris T, Xia Y, Salem S, Stewart AG

Measurement of endotoxins in bioaerosols at workplace: a critical review of literature and a standardization issue.

Endotoxins are lipopolysaccharides found in the outer membrane of most Gram-negative bacteria and cyanobacteria. Worker exposure to endotoxins has been shown in a number of work situations and is associated with both respiratory and systemic...

Authors: Duquenne P1, Marchand G, Duchaine C.

Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro

INTRODUCTION: Products using the antimicrobial properties of silver nanoparticles (Ag-nps) may be found in health and consumer products that routinely contact skin. OBJECTIVES: This study was designed to assess the potential cytotoxicity of Ag-nps...

Authors: Samberg ME, Oldenburg SJ, Monteiro-Riviere NA.

Electronegative low-density lipoprotein increases C-reactive protein expression in vascular endothelial cells through the LOX-1 receptor

OBJECTIVES: Increased plasma C-reactive protein (CRP) levels are associated with the occurrence and severity of acute coronary syndrome. We investigated whether CRP can be generated in vascular endothelial cells (ECs) after exposure to the most...

Authors: Chu CS, Wang YC, Lu LS, Walton B, Yilmaz HR, Huang RY, Sawamura T, Dixon RA, Lai WT, Chen CH, Lu J

Dietary oil composition differentially modulates intestinal endotoxin transport and postprandial endotoxemia.

BACKGROUND: Intestinal derived endotoxin and the subsequent endotoxemia can be considered major predisposing factors for diseases such as atherosclerosis, sepsis, obesity and diabetes. Dietary fat has been shown to increase postprandial...

Authors: Mani V1, Hollis JH, Gabler NK.

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus-Accelerated Atherosclerosis

BACKGROUND: In diabetes mellitus, vascular complications such as atherosclerosis are a major cause of death. The key underlying pathomechanisms are unclear. However, hyperglycemic oxidative stress derived from NADPH oxidase (Nox), the only known...

Authors: Gray SP, Di Marco E, Okabe J, Szyndralewiez C, Heitz F, Montezano AC, de Haan JB, Koulis C, El-Osta...

Desmosome assembly and disassembly are membrane raft-dependent.

Strong intercellular adhesion is critical for tissues that experience mechanical stress, such as the skin and heart. Desmosomes provide adhesive strength to tissues by anchoring desmosomal cadherins of neighboring cells to the intermediate filament...

Authors: Stahley SN, Saito M, Faundez V, Koval M, Mattheyses AL, Kowalczyk AP

Leptin promotes wound healing in the oral mucosa.

INTRODUCTION: Leptin, a 16 kDa circulating anti-obesity hormone, exhibits many physiological properties. Recently, leptin was isolated from saliva; however, its function in the oral cavity is still unclear. In this study, we investigated the...

Authors: Umeki H, Tokuyama R, Ide S, Okubo M, Tadokoro S, Tezuka M, Tatehara S, Satomura K.

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