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Characterization of Human Vaginal Mucosa Cells for Autologous In Vitro Cultured Vaginal Tissue Transplantation in Patients with MRKH Syndrome

Mayer-Rokitansky-Küster-Hauser (MRKH) is a rare syndrome characterized by congenital aplasia of the uterus and vagina. The most common procedure used for surgical reconstruction of the neovagina is the McIndoe vaginoplasty, which consists in creation...

Authors: Nodale C1, Vescarelli E1, D\\\'Amici S1, Maffucci D2, Ceccarelli S1, Monti M2, Benedetti Panici P2,...

The immunomodulatory action of sialostatin L on dendritic cells reveals its potential to interfere with autoimmunity.

Sialostatin L (SialoL) is a secreted cysteine protease inhibitor identified in the salivary glands of the Lyme disease vector Ixodes scapularis. In this study, we reveal the mechanisms of SialoL immunomodulatory actions on the vertebrate host....

Authors: Sá-Nunes A1, Bafica A, Antonelli LR, Choi EY, Francischetti IM, Andersen JF, Shi GP, Chavakis T,...

A role for parasite-induced PGE2 in IL-10-mediated host immunoregulation by skin stage schistosomula of Schistosoma mansoni

Significant quantities of PGE(2) were produced by cercariae of Schistosoma mansoni following incubation with linoleic acid, a free fatty acid found on the surface of the skin. Cyclooxygenase (COX) 2 inhibitors failed to block this PGE(2) production,...

Authors: Ramaswamy K, Kumar P, He YX.

Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle.

Type 2 diabetes is an increasing worldwide epidemic that poses major health problems. We have identified a novel physiological system that increases glucose uptake in skeletal muscle but not in white adipocytes. Activation of this system improves...

Authors: Sato M, Dehvari N, Oberg AI, Dallner OS, Sandström AL, Olsen JM, Csikasz RI, Summers RJ, Hutchinson...

SST Peer Reviewed

Evaluation of the Limulus amebocyte lysate and recombinant factor C assays for assessment of airborne endotoxin.

As a potent inflammatory agent, endotoxin is a key analyte of interest for studies of lung ailments in domestic environments and occupational settings with organic dust. A relatively unexplored advance in endotoxin exposure assessment is the use of...

Authors: Thorne PS1, Perry SS, Saito R, O\\\'Shaughnessy PT, Mehaffy J, Metwali N, Keefe T, Donham KJ,...

Effects of silver nanoparticles on primary mixed neural cell cultures: uptake, oxidative stress and acute calcium responses.

In the body, nanoparticles can be systemically distributed and then may affect secondary target organs, such as the central nervous system (CNS). Putative adverse effects on the CNS are rarely investigated to date. Here, we used a mixed primary cell...

Authors: Haase A1, Rott S, Mantion A, Graf P, Plendl J, Thünemann AF, Meier WP, Taubert A, Luch A, Reiser G.

An assessment of dust, endotoxin, and microorganism exposure during waste collection and sorting.

This study was conducted to assess inhalation exposure to dust, endotoxin, and microorganisms (including viable bacteria, Gram-negative bacteria [GNB], and fungi) during waste collection and sorting; to identify factors affecting this exposure; and...

Authors: Park DU1, Ryu SH, Kim SB, Yoon CS.

Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation.

Obese pregnant women develop severe insulin resistance and enhanced systemic and placental inflammation, suggesting associated modifications of endocrine and immune functions. Activation of innate immunity by endotoxins/lipopolysaccharides (LPS) has...

Authors: Basu S1, Haghiac M, Surace P, Challier JC, Guerre-Millo M, Singh K, Waters T, Minium J, Presley L,...

Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle.

Asexual blood stages of the malaria parasite, which cause all the pathology associated with malaria, can readily be genetically modified by homologous recombination, enabling the functional study of parasite genes that are not essential in this part...

Authors: Collins CR1, Das S, Wong EH, Andenmatten N, Stallmach R, Hackett F, Herman JP, Müller S, Meissner M,...

SST Peer Reviewed

Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process

The search for significantly overrepresented and co-occurring transcription factor binding sites in the promoter regions of the most differentially expressed genes in microarray data sets could be a powerful approach for finding key regulators of...

Authors: Roupé KM, Veerla S, Olson J, Stone EL, Sørensen OE, Hedrick SM, Nizet V

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