Search Results

Epigallocatechin-3-O-(3-O-methyl)-gallate-induced differentiation of human keratinocytes involves klotho-mediated regulation of protein kinase-cAMP responsive element-binding protein signaling

(-)-Epigallocatechin-3-O-gallate (EGCG) has long been known as a potent inducer of keratinocyte differentiation. Although its molecular mechanisms have been extensively studied, its actions on human skin remain to be elucidated. In this study, we...

Authors: Kim HJ, Chang H, Han SH, Lee MS, Jung JY, An S, Baek SY, Lee JH, Lee JH, Lee TR, Shin DW, Kim H

Endotoxin, coliform, and dust levels in various types of rodent bedding.

Endotoxins in grain dust, household dust, and animal bedding may induce respiratory symptoms in rodents and humans. We assayed the endotoxin, coliform, and dust levels in 20 types of rodent bedding. Endotoxin concentrations were measured by using a...

Authors: Whiteside TE1, Thigpen JE, Kissling GE, Grant MG, Forsythe D.

High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling

Fibroblast growth factor 2 (FGF-2) is a multifunctional protein synthesized as high (Hi-) and low (Lo-) molecular weight isoforms. Studies using rodent models showed that Hi- and Lo-FGF-2 exert distinct biological activities: after myocardial...

Authors: Santiago JJ, McNaughton LJ, Koleini N1, Ma X, Bestvater B, Nickel BE, Fandrich RR, Wigle JT, Freed...

Testosterone stimulates Duox1 activity through GPRC6A in skin keratinocytes.

Testosterone is an endocrine hormone with functions in the reproductive organs, anabolic events and skin homeostasis. We report here that GPRC6A serves as a sensor and mediator of the rapid action of testosterone in epidermal keratinocytes. The...

Authors: Ko E, Choi H, Kim B, Kim M, Park KN, Bae IH, Sung YK, Lee TR, Shin DW, Bae YS

Endotoxin emissions from commercial composting activities.

This paper describes an exploratory study of endotoxin emissions and dispersal from a commercial composting facility. Replicated samples of air were taken by filtration at different locations around the facility on 10 occasions. Measurements were...

Authors: Deacon L1, Pankhurst L, Liu J, Drew GH, Hayes ET, Jackson S, Longhurst J, Longhurst P, Pollard S,...

Cutting edge: Immunity against a \\\"silent\\\" salivary antigen of the Lyme vector Ixodes scapularis impairs its ability to feed.

Ixodes scapularis ticks transmit the Lyme disease agent in the United States. Although strong antitick immunity mediates tick rejection by certain vertebrates, only a few Ags have been molecularly characterized. We show that guinea pig vaccination...

Authors: Kotsyfakis M1, Anderson JM, Andersen JF, Calvo E, Francischetti IM, Mather TN, Valenzuela JG,...

Gene expression profile of patients with Mayer-Rokitansky-Küster-Hauser syndrome: new insights into the potential role of developmental pathways

Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is a rare disease characterized by congenital aplasia of uterus and vagina. Although many studies have investigated several candidate genes, up to now none of them seem to be responsible for the...

Authors: Nodale C, Ceccarelli S, Giuliano M, Cammarota M, D\\\'Amici S, Vescarelli E1, Maffucci D3, Bellati...

Egr-1 upregulates Siva-1 expression and induces cardiac fibroblast apoptosis

The early growth response transcription factor Egr-1 controls cell specific responses to proliferation, differentiation and apoptosis. Expression of Egr-1 and downstream transcription is closely controlled and cell specific upregulation induced by...

Authors: Zins K1, Pomyje J2, Hofer E3, Abraham D4, Lucas T5, Aharinejad S6.

The immunomodulatory action of sialostatin L on dendritic cells reveals its potential to interfere with autoimmunity.

Sialostatin L (SialoL) is a secreted cysteine protease inhibitor identified in the salivary glands of the Lyme disease vector Ixodes scapularis. In this study, we reveal the mechanisms of SialoL immunomodulatory actions on the vertebrate host....

Authors: Sá-Nunes A1, Bafica A, Antonelli LR, Choi EY, Francischetti IM, Andersen JF, Shi GP, Chavakis T,...

Characterization of Human Vaginal Mucosa Cells for Autologous In Vitro Cultured Vaginal Tissue Transplantation in Patients with MRKH Syndrome

Mayer-Rokitansky-Küster-Hauser (MRKH) is a rare syndrome characterized by congenital aplasia of the uterus and vagina. The most common procedure used for surgical reconstruction of the neovagina is the McIndoe vaginoplasty, which consists in creation...

Authors: Nodale C1, Vescarelli E1, D\\\'Amici S1, Maffucci D2, Ceccarelli S1, Monti M2, Benedetti Panici P2,...

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