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KDT501, a derivative from hops, normalizes glucose metabolism and body weight in rodent models of diabetes

AIMS/HYPOTHESIS: We developed KDT501, a novel substituted 1,3-cyclopentadione chemically derived from hop extracts, and evaluated it in various in vitro and in vivo models of diabetes and insulin sensitivity. METHODS: KDT501 was evaluated...

Authors: Konda VR, Desai A, Darland G, Grayson N, Bland JS

SST Peer Reviewed

Pathogenic strains of Acanthamoeba are recognized by TLR4 and initiated inflammatory responses in the cornea

Free-living amoebae of the Acanthamoeba species are the causative agent of Acanthamoeba keratitis (AK), a sight-threatening corneal infection that causes severe pain and a characteristic ring-shaped corneal infiltrate. Innate immune responses play an...

Authors: Alizadeh H, Tripathi T, Abdi M, Smith AD.

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing

Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning. Although defective alternative splicing has been linked to SZ, the molecular mechanisms responsible are unknown. Additionally, there is limited understanding of...

Authors: Barry G, Briggs JA, Vanichkina DP, Poth EM, Beveridge NJ, Ratnu VS, Nayler SP, Nones K, Hu J, Bredy...

SST Peer Reviewed

Down-regulation of the Antisense Mitochondrial ncRNAs is a Unique Vulnerability of Cancer Cells and a Potential Target for Cancer Therapy

Hallmarks of cancer are fundamental principles involved in cancer progression. We propose an additional generalized hallmark of malignant transformation, corresponding to the differential expression of a family of mitochondrial ncRNAs (ncmtRNAs),...

Authors: Vidaurre S1, Fitzpatrick C2, Burzio VA3, Briones M2, Villota C2, Villegas J2, Echenique J2,...

The cellular basis for biocide-induced fluorescein hyperfluorescence in mammalian cell culture

Clinical examination of the ocular surface is commonly carried out after application of sodium fluorescein in both veterinary and medical practice by assessing the resulting 'staining'. Although localized intensely stained regions of the cornea...

Authors: Bakkar MM, Hardaker L, March P, Morgan PB, Maldonado-Codina C, Dobson CB

Human dermal stem/progenitor cell-derived conditioned medium ameliorates ultraviolet a-induced damage of normal human dermal fibroblasts

Adult skin stem cells are considered an attractive cell resource for therapeutic potential in aged skin. We previously reported that multipotent human dermal stem/progenitor cells (hDSPCs) can be enriched from (normal human dermal fibroblasts (NHDFs)...

Authors: Shim JH, Park JY, Lee MG, Kang HH, Lee TR, Shin DW

DA-6034 Induces [Ca(2+)]i Increase in Epithelial Cells

DA-6034, a eupatilin derivative of flavonoid, has shown potent effects on the protection of gastric mucosa and induced the increases in fluid and glycoprotein secretion in human and rat corneal and conjunctival cells, suggesting that it might be...

Authors: Yang YM1, Park S1, Ji H1, Kim TI2, Kim EK2, Kang KK3, Shin DM1.

Regulation of Human Trophoblast GLUT1 Glucose Transporter by Insulin-Like Growth Factor I (IGF-I)

Glucose transport to the fetus across the placenta takes place via glucose transporters in the opposing faces of the barrier layer, the microvillous and basal membranes of the syncytiotrophoblast. While basal membrane content of the GLUT1 glucose...

Authors: Baumann MU, Schneider H, Malek A, Palta V, Surbek DV, Sager R, Zamudio S, Illsley NP

Comparison of ectopic gene expression methods in rat neural stem cells.

Neural stem cells (NSCs) have the ability to proliferate and differentiate into various types of cells that compose the nervous system. To study functions of genes in stem cell biology, genes or siRNAs need to be transfected. However, it is difficult...

Authors: Kim W, Kim JH, Kong SY, Park MH, Sohn UD, Kim HJ.

SST Peer Reviewed

Quantitative proteomic analysis of oral brush biopsies identifies secretory leukocyte protease inhibitor as a promising, mechanism-based oral cancer biomarker

A decrease in the almost fifty percent mortality rate from oral cancer is needed urgently. Improvements in early diagnosis and more effective preventive treatments could affect such a decrease. Towards this end, we undertook for the first time an...

Authors: Yang Y, Rhodus NL, Ondrey FG, Wuertz BR, Chen X, Zhu Y, Griffin TJ

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KDT501, a derivative from hops, normalizes glucose metabolism and body weight in rodent models of diabetes

Pathogenic strains of Acanthamoeba are recognized by TLR4 and initiated inflammatory responses in the cornea

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing

Down-regulation of the Antisense Mitochondrial ncRNAs is a Unique Vulnerability of Cancer Cells and a Potential Target for Cancer Therapy

The cellular basis for biocide-induced fluorescein hyperfluorescence in mammalian cell culture

Human dermal stem/progenitor cell-derived conditioned medium ameliorates ultraviolet a-induced damage of normal human dermal fibroblasts

DA-6034 Induces [Ca(2+)]i Increase in Epithelial Cells

Regulation of Human Trophoblast GLUT1 Glucose Transporter by Insulin-Like Growth Factor I (IGF-I)

Comparison of ectopic gene expression methods in rat neural stem cells.

Quantitative proteomic analysis of oral brush biopsies identifies secretory leukocyte protease inhibitor as a promising, mechanism-based oral cancer biomarker