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Sleeping Beauty Transposon-mediated Engineering of Human Primary T Cells for Therapy of CD19(+) Lymphoid Malignancies

We have reported earlier that the non-viral Sleeping Beauty (SB) transposon system can mediate genomic integration and long-term reporter gene expression in human primary peripheral blood (PB) T cells. In order to test whether this system can be used...

Authors: Huang X, Guo H, Kang J, Choi S, Zhou TC, Tammana S, Lees CJ, Li ZZ, Milone M, Levine BL, Tolar J,...

SST Peer Reviewed

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

Expression of IL-22 is induced in several human inflammatory conditions, including inflammatory bowel disease (IBD). Expression of the IL-22 receptor is restricted to innate immune cells; however, the role of IL-22 in colitis has not yet been...

Authors: Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ, Mizoguchi...

Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4 as the enzyme deficient in Agpat6-/- mice

Elucidation of the metabolic pathways of triacylglycerol synthesis is critical to the understanding of chronic metabolic disorders such as obesity, cardiovascular disease, and diabetes. Glycerol-sn-3-phosphate acyltransferase (GPAT) and...

Authors: Nagle CA, Vergnes L, Dejong H, Wang S, Lewin TM, Reue K, Coleman RA

CRE recombinase-based positive-negative selection systems for genetic manipulation in Trypanosoma brucei

The limited repertoire of drug-resistance markers imposes a serious obstacle to genetic manipulation of Trypanosoma brucei. Here we describe experiments with a fusion protein that allows positive selection for genome integration followed by CRE...

Authors: Scahill MD, Pastar I, Cross GA

NF-kappaB-mediated activation of the chemokine CCL22 by the product of the human cytomegalovirus gene UL144 escapes regulation by viral IE86

The product of the human cytomegalovirus (HCMV) gene UL144, expressed at early times postinfection, is located in the UL/b' region of the viral genome and is related to members of the tumor necrosis factor receptor superfamily, but it does not bind...

Authors: Poole E, Atkins E, Nakayama T, Yoshie O, Groves I, Alcami A, Sinclair J

Cholesterol Loss Enhances TrkB Signaling in Hippocampal Neurons Aging in Vitro

Binding of the neurotrophin BDNF to the TrkB receptor is a major survival mechanism during embryonic development. In the aged brain however, BDNF levels are low, suggesting that if TrkB is to play a role in survival at this stage additional...

Authors: Martin MG, Perga S, TrovÜ² L, Rasola A, Holm P, Rantamäki T, Harkany T, Castrén E, Chiara F, Dotti...

Adrenomedullin signaling is necessary for murine lymphatic vascular development

The lymphatic vascular system mediates fluid homeostasis, immune defense, and tumor metastasis. Only a handful of genes are known to affect the development of the lymphatic vasculature, and even fewer represent therapeutic targets for lymphatic...

Authors: Fritz-Six KL, Dunworth WP, Li M, Caron KM

Pyramidal neuron polarity axis is defined at the bipolar stage

In situ observations of the development of hippocampal and cortical neurons indicate that final axon-dendrite identity is defined at the time of generation of the first two, oppositely positioned, neurites. Quite differently, in vitro studies...

Authors: Calderon de Anda F, Gärtner A, Tsai LH, Dotti CG

Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice

Endothelial dysfunction is a key triggering event in atherosclerosis. Following the entry of lipoproteins into the vessel wall, their rapid modification results in the generation of advanced glycation endproduct epitopes and subsequent infiltration...

Authors: Harja E, Bu DX, Hudson BI, Chang JS, Shen X, Hallam K, Kalea AZ, Lu Y, Rosario RH, Oruganti S,...

A function retained by the common mutant CLN3 protein is responsible for the late onset of juvenile neuronal ceroid lipofuscinosis

The neuronal ceroid lipofuscinoses (NCLs) are common neurodegenerative disorders of childhood and are classified as lysosomal storage diseases since affected cells exhibit lysosomes containing ceroid and lipofuscin-like material. CLN3 is the most...

Authors: Kitzmuller C, Haines RL, Codlin S, Cutler DF, Mole SE

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