Search Results

Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury

Hypoxia-inducible factor (HIF)-1a, part of the heterodimeric transcription factor that mediates the cellular response to hypoxia, is critical for the expression of multiple angiogenic growth factors, cell motility, and the recruitment of endothelial...

Authors: Zimmermann AS, Morrison SD, Hu MS, Li S, Nauta A, Sorkin M, Meyer NP, Walmsley GG, Maan ZN, Chan DA,...

Anacardic acid enhances the anticancer activity of liposomal mitoxantrone towards melanoma cell lines - in vitro studies

THIS PAPER DESCRIBES A NOVEL FORMULATION OF ANTINEOPLASTIC DRUG: mitoxantrone loaded into liposomal carriers enriched with encapsulated anacardic acid in the liposomal bilayer using a vitamin C gradient. Anacardic acid is a potent epigenetic agent...

Authors: Legut M, Lipka D, Filipczak N, Piwoni A, Kozubek A, Gubernator J.

A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo

Targeting angiogenesis is a promising approach to the treatment of solid tumors and age-related macular degeneration (AMD). Inhibition of vascularization has been validated by the successful marketing of monoclonal antibodies (mAbs) that target...

Authors: Mabry R, Gilbertson DG, Frank A, Vu T, Ardourel D, Ostrander C, Stevens B, Julien S, Franke S,...

Second Generation Cardiac Cell Therapy: Combining Cardiac Stem Cells and Circulating Angiogenic Cells for the Treatment of Ischemic Heart Disease

Blood-derived circulatory angiogenic cells (CACs) and resident cardiac stem cells (CSCs) have both been shown to improve cardiac function after myocardial infarction (MI) but the superiority of either cell type has long been an area of speculation...

Authors: Nicholas Latham

KDT501, a derivative from hops, normalizes glucose metabolism and body weight in rodent models of diabetes

AIMS/HYPOTHESIS: We developed KDT501, a novel substituted 1,3-cyclopentadione chemically derived from hop extracts, and evaluated it in various in vitro and in vivo models of diabetes and insulin sensitivity. METHODS: KDT501 was evaluated...

Authors: Konda VR, Desai A, Darland G, Grayson N, Bland JS

SST Peer Reviewed

Birt-Hogg-Dube syndrome is a novel ciliopathy

Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant disorder where patients are predisposed to kidney cancer, lung and kidney cysts and benign skin tumors. BHD is caused by heterozygous mutations affecting folliculin (FLCN), a conserved protein...

Authors: Luijten MN1, Basten SG, Claessens T, Vernooij M, Scott CL, Janssen R, Easton JA, Kamps MA, Vreeburg...

Inhibition of ataxia telangiectasia mutated (ATM) kinase suppresses herpes simplex virus type 1 (HSV-1) keratitis

PURPOSE: Herpes keratitis (HK) remains the leading cause of cornea-derived blindness in the developed world, despite the availability of effective antiviral drugs. Treatment toxicity and the emergence of drug resistance highlight the need for...

Authors: Alekseev O, Donovan K, Azizkhan-Clifford J.

Platelet-derived growth factor BB mediates the tropism of human mesenchymal stem cells for malignant gliomas

OBJECTIVE: Bone marrow-derived human mesenchymal stem cells (hMSCs) are capable of localizing to gliomas after systemic delivery and can be used in glioma therapy. However, the mechanism underlying the tropism of hMSCs for gliomas remains...

Authors: Hata N, Shinojima N, Gumin J, Yong R, Marini F, Andreeff M, Lang FF.

Nonthermal Dielectric Barrier Discharge (DBD) Plasma Suppresses Herpes Simplex Virus Type 1 (HSV-1) Replication in Corneal Epithelium

PURPOSE: Herpes keratitis (HK) is the leading cause of cornea-derived and infection-associated blindness in the developed world. Despite the availability of effective antivirals, some patients develop refractory disease, drug-resistant infection,...

Authors: Alekseev O, Donovan K, Limonnik V, Azizkhan-Clifford J.

Systematic microRNA analysis identifies ATP6V0C as an essential host factor for human cytomegalovirus replication

Recent advances in microRNA target identification have greatly increased the number of putative targets of viral microRNAs. However, it is still unclear whether all targets identified are biologically relevant. Here, we use a combined approach of...

Authors: Pavelin J, Reynolds N, Chiweshe S, Wu G, Tiribassi R, Grey F

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