Search Results

Genome-wide binding and transcriptome analysis of human farnesoid x receptor in primary human hepatocytes

BACKGROUND & AIMS: Farnesoid X receptor (FXR, NR1H4) is a ligand-activated transcription factor, belonging to the nuclear receptor superfamily. FXR is highly expressed in the liver and is essential in regulating bile acid homeostasis. FXR...

Authors: Zhan L, Liu HX, Fang Y, Kong B, He Y, Zhong XB, Fang J, Wan YJ, Guo GL.

Effect of lamin A/C knockdown on osteoblast differentiation and function

Recent studies have associated mutations in lamin A/C, a component of the nuclear lamina, with premature aging and severe bone loss. In this study, we hypothesized that reduced expression of lamin A/C has a negative impact on osteoblastogenesis and...

Authors: Akter R, Rivas D, Geneau G, Drissi H, Duque G.

Second Generation Cardiac Cell Therapy: Combining Cardiac Stem Cells and Circulating Angiogenic Cells for the Treatment of Ischemic Heart Disease

Blood-derived circulatory angiogenic cells (CACs) and resident cardiac stem cells (CSCs) have both been shown to improve cardiac function after myocardial infarction (MI) but the superiority of either cell type has long been an area of speculation...

Authors: Nicholas Latham

Calcitriol May Down-Regulate mRNA Over-Expression of Toll-Like Receptor-2 and -4, LL-37 and Proinflammatory Cytokines in Cultured Human Keratinocytes

Although vitamin D analogs have been used in the topical treatment of psoriasis, their mechanisms of action are not well understand. Calcitriol, the hormonally active vitamin D3 metabolite, has been demonstrated to exert immunomodulatory effects in...

Authors: Jeong MS, Kim JY, Lee HI, Seo SJ.

Birt-Hogg-Dube syndrome is a novel ciliopathy

Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant disorder where patients are predisposed to kidney cancer, lung and kidney cysts and benign skin tumors. BHD is caused by heterozygous mutations affecting folliculin (FLCN), a conserved protein...

Authors: Luijten MN1, Basten SG, Claessens T, Vernooij M, Scott CL, Janssen R, Easton JA, Kamps MA, Vreeburg...

Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture

Human bone marrow mesenchymal stem cells (MSCs) expanded in vitro exhibit not only a tendency to lose their proliferative potential, homing ability and telomere length but also genetic or epigenetic modifications, resulting in senescence. We compared...

Authors: Choi MR, In YH, Park J, Park T, Jung KH, Chai JC, Chung MK, Lee YS, Chai YG.

Hypoxia-mediated Up-regulation of Metastatic Genes in Human Tongue Oral Squamous Cell Carcinoma: [Part I] Urokinase Plasminogen Activator [uPA]

Background: Most human tumors develops regions of chronically or transient hypoxic cells during growth. The effect of hypoxia on tumor tissue has a strong impact on tumor cell migration and metastatic behavior. uPA a major member plasminogen...

Authors: Khaled M. Mohamed, BDS, MDS, PhD.

Hair cycle control by leptin as a new anagen inducer.

Our purpose is to clarify the physiological role of leptin in hair cycle as leptin reportedly causes activation of Stat3, which is indispensable for hair cycling. While hair follicles in dorsal skin of 5-week-old C57/BL6 mice had progressed to late...

Authors: Sumikawa Y, Inui S, Nakajima T, Itami S.

Systematic microRNA analysis identifies ATP6V0C as an essential host factor for human cytomegalovirus replication

Recent advances in microRNA target identification have greatly increased the number of putative targets of viral microRNAs. However, it is still unclear whether all targets identified are biologically relevant. Here, we use a combined approach of...

Authors: Pavelin J, Reynolds N, Chiweshe S, Wu G, Tiribassi R, Grey F

In vitro and in vivo optimization of infrared laser treatment for injured peripheral nerves

BACKGROUND AND OBJECTIVE: Repair of peripheral nerve injuries remains a major challenge in restorative medicine. Effective therapies that can be used in conjunction with surgical nerve repair to improve nerve regeneration and functional recovery are...

Authors: Anders JJ, Moges H, Wu X, Erbele ID, Alberico SL, Saidu EK, Smith JT, Pryor BA.

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