Search Results

Integrated Analysis of Rifampicin-induced MicroRNA and Gene Expression Changes in Human Hepatocytes

MicroRNAs (miRNAs) post-transcriptionally regulate mRNA expression, controlling global cell function. Altered expression or function of miRNAs causes various diseases. Chemically induced changes in miRNA expression in human tissues are not fully...

Authors: Takahashi K, Tatsumi N, Fukami T, Yokoi T, Nakajima M.

Smaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy

We report the identification and characterization of a previously unknown suppressor of myopathy caused by expansion of CUG repeats, the mutation that triggers Myotonic Dystrophy Type 1 (DM1). We screened a collection of genes encoding RNA-binding...

Authors: de Haro M, Al-Ramahi I, Jones KR, Holth JK, Timchenko LT, Botas J.

Characterization of autologous mesenchymal stem cell-derived neural progenitors as a feasible source of stem cells for central nervous system applications in multiple sclerosis

Bone marrow mesenchymal stem cell-derived neural progenitors (MSC-NPs) are a potential therapeutic source of cells that have been shown to be efficacious in a preclinical model of multiple sclerosis (MS). To examine the feasibility of using MSC-NPs...

Authors: Harris VK, Faroqui R, Vyshkina T, Sadiq SA.

A bioengineered heterotypic stroma-cancer microenvironment model to study pancreatic ductal adenocarcinoma

Interactions between neoplastic epithelial cells and components of a reactive stroma in pancreatic ductal adenocarcinoma (PDAC) are of key significance behind the disease's dismal prognosis. Despite extensive published research in the importance of...

Authors: Drifka CR, Eliceiri KW, Weber SM, Kao WJ

Bone progenitors produced by direct osteogenic differentiation of the unprocessed bone marrow demonstrate high osteogenic potential in vitro and in vivo

Tissue-engineered bone grafts seeded with mesenchymal stem cells (MSCs) have been sought as a replacement for bone grafts currently used for bone repair. For production of osteogenic constructs, MSCs are isolated from bone marrow (BM) or other...

Authors: Ginis I, Weinreb M, Abramov N, Shinar D, Merchav S, Schwartz A, Shirvan M.

Elaidate, an 18-carbon trans-monoenoic fatty acid, inhibits ß-oxidation in human peripheral blood macrophages

Consumption of trans-unsaturated fatty acids promotes atherosclerosis, but whether degradation of fats in macrophages is altered by trans-unsaturated fatty acids is unknown. We compared the metabolism of oleate (C18:1?9-10 cis; (Z)-octadec-9-enoate),...

Authors: Zacherl JR, Mihalik SJ, Chace DH, Christensen TC, Robinson LJ, Blair HC.

The mitogen-activated protein (MAP) kinases p38 and extracellular signal-regulated kinase (ERK) are involved in hepatocyte-mediated phenotypic switching in prostate cancer cells

The greatest challenge for the seeding of cancer in metastatic sites is integration into the ectopic microenvironment despite the lack of an orthotopic supportive environment and presence of pro-death signals concomitant with a localized...

Authors: Ma B, Wells A.

An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells.

The generation of induced pluripotent stem cells (iPSCs) provides the opportunity to use patient-specific somatic cells, which are a valuable source for disease modeling and drug discovery. To promote research involving these cells, it is important...

Authors: Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Watanabe A, Goshima N, Yamanaka S.

SST Peer Reviewed

Replication of chimeric yellow fever virus-dengue serotype 1-4 virus vaccine strains in dendritic and hepatic cells

ChimeriVax-dengue (DEN) viruses are live attenuated vaccine candidates. They are constructed by replacing the premembrane (prM) and envelope (E) genes of the yellow fever (YF) 17D virus vaccine with the corresponding genes from wild-type DEN viruses...

Authors: Brandler S, Brown N, Ermak TH, Mitchell F, Parsons M, Zhang Z, Lang J, Monath TP, Guirakhoo F.

Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6

Hepcidin, the iron-regulatory hormone, is increased during infection or inflammation, causing hypoferremia. This response is thought to be a host defense mechanism that restricts iron availability to invading pathogens. It is not known if hepcidin is...

Authors: Rodriguez R1, Jung CL, Gabayan V, Deng JC, Ganz T, Nemeth E, Bulut Y.

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin